DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p24-2 and Tmed10

DIOPT Version :9

Sequence 1:	NP_001189205.1	Gene:	p24-2 / 318890	FlyBaseID:	FBgn0053105	Length:	244	Species:	Drosophila melanogaster
Sequence 2:	NP_081051.1	Gene:	Tmed10 / 68581	MGIID:	1915831	Length:	219	Species:	Mus musculus

Alignment Length:	199	Identity:	63/199 - (31%)
Similarity:	105/199 - (52%)	Gaps:	9/199 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LALILCVLHSACGLYFHISQTERKCFIEEVPDETTVIVNYKVELYDPRSNGFMPSSPGIGMHVEV 72
            |.|:|....|..|:.||:....|||..||:..:..|...|::   ..:|.|    :.|:..|:::
Mouse    19 LFLLLLGPSSVLGISFHLPVNSRKCLREEIHKDLLVTGAYEI---TDQSGG----AGGLRTHLKI 76

  Fly    73 RDSDDKIVLSRVYSSQGRISFTSHTPGEHVICMFSNSTAWFSGAQLRVHLDIQVGEHAIDYAHVA 137
            .||...|:.::..:::|:.:||:.......:|..|..|..... || |.||::.|..|.:|..:|
Mouse    77 TDSAGHILYAKEDATKGKFAFTTEDYDMFEVCFESKGTGRIPD-QL-VILDMKHGVEAKNYEEIA 139

  Fly   138 QKEKLTELQLRIRQLLDQVEQITKEQNYQRYREERFRHTSESTNSRVLWWSLAQTVVLVCMGFWH 202
            :.|||..|::.:|:|.|..|.|..:..|.:.|||..|.|:||||:|||::|:.....|:.:..|.
Mouse   140 KVEKLKPLEVELRRLEDLSESIVNDFAYMKKREEEMRDTNESTNTRVLYFSIFSMFCLIGLATWQ 204

  Fly   203 LFNL 206
            :|.|
Mouse   205 VFYL 208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p24-2	NP_001189205.1	EMP24_GP25L	20..206	CDD:279450	58/185 (31%)
Tmed10	NP_081051.1	Required for interaction with STX17. /evidence=ECO:0000250	1..142		36/131 (27%)
		EMP24_GP25L	31..213	CDD:279450	59/187 (32%)
		Required for TMED10 and TMED2 cis-Golgi network localization. /evidence=ECO:0000250	147..178		11/30 (37%)
		Interaction with COPG1. /evidence=ECO:0000250	204..219		2/5 (40%)
		Interaction with ARF1 and IL1B. /evidence=ECO:0000250\|UniProtKB:P49755	207..219		1/2 (50%)
		COPI vesicle coat-binding. /evidence=ECO:0000255	211..219
		COPII vesicle coat-binding. /evidence=ECO:0000255	211..212
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53581
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X178
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920