Protein Alignment p24-2 and Tmed10

DIOPT Version :10

• Sequence 1: NP_788617.1
• Gene: p24-2 / 318890
• FlyBaseID: FBgn0053105
• Length: 244
• Species: Drosophila melanogaster
• Sequence 2: NP_081051.1
• Gene: Tmed10 / 68581
• MGIID: 1915831
• Length: 219
• Species: Mus musculus
• Alignment Length: 199
• Identity: 63/199 - (31%)
• Similarity: 105/199 - (52%)
• Gaps: 9/199 - (4%)

  Fly     8 LALILCVLHSACGLYFHISQTERKCFIEEVPDETTVIVNYKVELYDPRSNGFMPSSPGIGMHVEV 72
            |.|:|....|..|:.||:....|||..||:..:..|...|::   ..:|.|    :.|:..|:::
Mouse    19 LFLLLLGPSSVLGISFHLPVNSRKCLREEIHKDLLVTGAYEI---TDQSGG----AGGLRTHLKI 76

  Fly    73 RDSDDKIVLSRVYSSQGRISFTSHTPGEHVICMFSNSTAWFSGAQLRVHLDIQVGEHAIDYAHVA 137
            .||...|:.::..:::|:.:||:.......:|..|..|..... || |.||::.|..|.:|..:|
Mouse    77 TDSAGHILYAKEDATKGKFAFTTEDYDMFEVCFESKGTGRIPD-QL-VILDMKHGVEAKNYEEIA 139

  Fly   138 QKEKLTELQLRIRQLLDQVEQITKEQNYQRYREERFRHTSESTNSRVLWWSLAQTVVLVCMGFWH 202
            :.|||..|::.:|:|.|..|.|..:..|.:.|||..|.|:||||:|||::|:.....|:.:..|.
Mouse   140 KVEKLKPLEVELRRLEDLSESIVNDFAYMKKREEEMRDTNESTNTRVLYFSIFSMFCLIGLATWQ 204

  Fly   203 LFNL 206
            :|.|
Mouse   205 VFYL 208

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
p24-2	NP_788617.1	EMP24_GP25L	20..206	CDD:426051	58/185 (31%)
Tmed10	NP_081051.1	Required for interaction with STX17. /evidence=ECO:0000250	1..142		36/131 (27%)
		EMP24_GP25L	31..213	CDD:426051	59/187 (32%)
		Required for TMED10 and TMED2 cis-Golgi network localization. /evidence=ECO:0000250	147..178		11/30 (37%)
		Interaction with COPG1. /evidence=ECO:0000250	204..219		2/5 (40%)
		Interaction with ARF1 and IL1B. /evidence=ECO:0000250|UniProtKB:P49755	207..219		1/2 (50%)
		COPI vesicle coat-binding. /evidence=ECO:0000255	211..219
		COPII vesicle coat-binding. /evidence=ECO:0000255	211..212