DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p24-2 and TMED10

DIOPT Version :9

Sequence 1:	NP_001189205.1	Gene:	p24-2 / 318890	FlyBaseID:	FBgn0053105	Length:	244	Species:	Drosophila melanogaster
Sequence 2:	NP_006818.3	Gene:	TMED10 / 10972	HGNCID:	16998	Length:	219	Species:	Homo sapiens

Alignment Length:	202	Identity:	64/202 - (31%)
Similarity:	105/202 - (51%)	Gaps:	12/202 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LALILCVL---HSACGLYFHISQTERKCFIEEVPDETTVIVNYKVELYDPRSNGFMPSSPGIGMH 69
            |||:|..|   .....:.||:....|||..||:..:..|...|::   ..:|.|    :.|:..|
Human    16 LALLLLFLLGPRLVLAISFHLPINSRKCLREEIHKDLLVTGAYEI---SDQSGG----AGGLRSH 73

  Fly    70 VEVRDSDDKIVLSRVYSSQGRISFTSHTPGEHVICMFSNSTAWFSGAQLRVHLDIQVGEHAIDYA 134
            :::.||...|:.|:..:::|:.:||:.......:|..|..|..... || |.||::.|..|.:|.
Human    74 LKITDSAGHILYSKEDATKGKFAFTTEDYDMFEVCFESKGTGRIPD-QL-VILDMKHGVEAKNYE 136

  Fly   135 HVAQKEKLTELQLRIRQLLDQVEQITKEQNYQRYREERFRHTSESTNSRVLWWSLAQTVVLVCMG 199
            .:|:.|||..|::.:|:|.|..|.|..:..|.:.|||..|.|:||||:|||::|:.....|:.:.
Human   137 EIAKVEKLKPLEVELRRLEDLSESIVNDFAYMKKREEEMRDTNESTNTRVLYFSIFSMFCLIGLA 201

  Fly   200 FWHLFNL 206
            .|.:|.|
Human   202 TWQVFYL 208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p24-2	NP_001189205.1	EMP24_GP25L	20..206	CDD:279450	58/185 (31%)
TMED10	NP_006818.3	Required for interaction with STX17. /evidence=ECO:0000269\|PubMed:21545355	1..142		37/134 (28%)
		EMP24_GP25L	31..213	CDD:395878	59/187 (32%)
		Required for TMED10 and TMED2 cis-Golgi network localization	147..178		11/30 (37%)
		Interaction with COPG1	204..219		2/5 (40%)
		Interaction with ARF1 and IL1B. /evidence=ECO:0000269\|PubMed:11726511, ECO:0000269\|PubMed:32272059	207..219		1/2 (50%)
		COPI vesicle coat-binding	211..219
		COPII vesicle coat-binding	211..212
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53581
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X178
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920