DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tengl1 and NUC1

DIOPT Version :9

Sequence 1:	NP_722780.1	Gene:	Tengl1 / 318883	FlyBaseID:	FBgn0051682	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	NP_012327.1	Gene:	NUC1 / 853222	SGDID:	S000003744	Length:	329	Species:	Saccharomyces cerevisiae

Alignment Length:	254	Identity:	66/254 - (25%)
Similarity:	112/254 - (44%)	Gaps:	53/254 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 RPDNS----EFDVDTDDCHKLGGIMKYGFPS-TNDITINETFDFVTSFDRRNSAILWMCERV--- 117
            :|:::    .|:||.      .|..|||||. .:|:...|  :|::.::|:.....|:.|.:
Yeast    42 KPNSNIQSHSFNVDP------SGFFKYGFPGPIHDLQNRE--EFISCYNRQTQNPYWVLEHITPE 98

  Fly   118 -------DLSN---------------------RVVYGDSTSVAPA--GAFGQSEAARVFFLSNIR 152
                   |..|                     |..| |....|||  ..|.|......|:|||:.
Yeast    99 SLAARNADRKNSFFKEDEVIPEKFRGKLRDYFRSGY-DRGHQAPAADAKFSQQAMDDTFYLSNMC 162

  Fly   153 PFLNRGFNLTVWDRLLQYVHEMSQRHGTVYAYTGSIYLP-RELKSNSWFLEFQ-SEERTMVAVPT 215
            |.:..|||...|..|..:...:::::.:|...||.:||| ::...|.:.:.:: ......:||||
Yeast   163 PQVGEGFNRDYWAHLEYFCRGLTKKYKSVRIVTGPLYLPKKDPIDNKFRVNYEVIGNPPSIAVPT 227

  Fly   216 HFFKILVIDKKFAG---DTIPYAEAYVMPNSPLNNNVELKTLLSDVREIENATGLRFFE 271
            ||||::|.:...|.   :.|..| |:|:||.|::|..:|......:..:|.:|||...:
Yeast   228 HFFKLIVAEAPTANPAREDIAVA-AFVLPNEPISNETKLTDFEVPIDALERSTGLELLQ 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tengl1	NP_722780.1	Endonuclease_NS	98..275	CDD:214889	54/212 (25%)
NUC1	NP_012327.1	NUC1	8..308	CDD:224777	66/254 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1864
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S973
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003231
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.820