DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31681 and TMPRSS4

DIOPT Version :9

Sequence 1:	NP_722789.1	Gene:	CG31681 / 318882	FlyBaseID:	FBgn0051681	Length:	264	Species:	Drosophila melanogaster
Sequence 2:	XP_005271670.1	Gene:	TMPRSS4 / 56649	HGNCID:	11878	Length:	494	Species:	Homo sapiens

Alignment Length:	264	Identity:	103/264 - (39%)
Similarity:	142/264 - (53%)	Gaps:	33/264 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LVSIAGLACAARIPGPEERIVGGSYIPIEYVPWQVSVQNNSLHCCGGVIYSDRAILTAAHCLSNV 74
            |||:..|||...:..|  |:||.....::..|||||:|.:..|.|||.|.....:||||||....
Human   188 LVSLHCLACGKSLKTP--RVVGVEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKH 250

  Fly    75 T-VTDLSVRAGSSYWSKGGQ-----VLKVLKTIAHPKYVPKLYNPYDIAVLILEAPLRLGGTVKK 133
            | |.:..|||||   .|.|.     |.|::....:|.| ||   ..|||::.|:.||...|||:.
Human   251 TDVFNWKVRAGS---DKLGSFPSLAVAKIIIIEFNPMY-PK---DNDIALMKLQFPLTFSGTVRP 308

  Fly   134 IPL----AEQTPVAGTIVLTSGWGYTRENSSFLWPILQGVHVAILNRTDCL--KAYKHVNITIDM 192
            |.|    .|.||.....::  |||:|::|...:..||....|.:::.|.|.  .||:. .:|..|
Human   309 ICLPFFDEELTPATPLWII--GWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQG-EVTEKM 370

  Fly   193 ICA---DGQRWDTCQGDSGGPLIETTKGGHRQLIGMVSWGDGCG--TNPGVYEDIAFFHNWIKYT 252
            :||   :| ..|||||||||||:..:...|  ::|:||||.|||  :.||||..::.:.||| |.
Human   371 MCAGIPEG-GVDTCQGDSGGPLMYQSDQWH--VVGIVSWGYGCGGPSTPGVYTKVSAYLNWI-YN 431

  Fly   253 VKKN 256
            |.|:
Human   432 VWKD 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31681	NP_722789.1	Tryp_SPc	28..249	CDD:214473	91/237 (38%)
CG31681	NP_722789.1	Tryp_SPc	29..250	CDD:238113	91/237 (38%)
TMPRSS4	XP_005271670.1	LDLa	58..92	CDD:238060
		SRCR_2	108..197	CDD:295335	5/8 (63%)
		Tryp_SPc	204..429	CDD:214473	91/237 (38%)
		Tryp_SPc	205..432	CDD:238113	93/240 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5417
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860