DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG31681 and KLK12

DIOPT Version :9

Sequence 1:NP_722789.1 Gene:CG31681 / 318882 FlyBaseID:FBgn0051681 Length:264 Species:Drosophila melanogaster
Sequence 2:NP_062544.1 Gene:KLK12 / 43849 HGNCID:6360 Length:254 Species:Homo sapiens


Alignment Length:252 Identity:83/252 - (32%)
Similarity:122/252 - (48%) Gaps:40/252 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 LLLSILVSIAGLACAARIPGPEERIVGGSYIPIEYVPWQVSVQNNSLHCCGGVIYSDRAILTAAH 69
            |.:.:|:.:.||:.||     ..:|..|:.......||||.:...:...||||:...|.:|||||
Human     3 LSIFLLLCVLGLSQAA-----TPKIFNGTECGRNSQPWQVGLFEGTSLRCGGVLIDHRWVLTAAH 62

  Fly    70 CLSNVTVTDLSVRAGSSYWSKGG-----------QVLKVLKTIAHPKYV-PKLYNPYDIAVLILE 122
            |            :||.||.:.|           |:.....::.||.|: ....:.:|:.:|.|.
Human    63 C------------SGSRYWVRLGEHSLSQLDWTEQIRHSGFSVTHPGYLGASTSHEHDLRLLRLR 115

  Fly   123 APLRLGGTVKKIPLAEQTPVAGTIVLTSGWGYTRENSSFLWPILQGVHVAILNRTDCLKAYKHVN 187
            .|:|:..:|:.:||......|||....||||.|....:....:||.::::|::...|...|.. .
Human   116 LPVRVTSSVQPLPLPNDCATAGTECHVSGWGITNHPRNPFPDLLQCLNLSIVSHATCHGVYPG-R 179

  Fly   188 ITIDMICADG-QRWDTCQGDSGGPLIETTKGGHRQLIGMVSWGD--GCGTN--PGVY 239
            ||.:|:||.| ...|.|||||||||:   .||..|  |:||||.  .||.:  ||||
Human   180 ITSNMVCAGGVPGQDACQGDSGGPLV---CGGVLQ--GLVSWGSVGPCGQDGIPGVY 231

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31681NP_722789.1 Tryp_SPc 28..249 CDD:214473 77/229 (34%)
Tryp_SPc 29..250 CDD:238113 77/228 (34%)
KLK12NP_062544.1 Tryp_SPc 21..236 CDD:214473 77/229 (34%)
Tryp_SPc 22..236 CDD:238113 77/228 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D469244at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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