DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31681 and PRSS36

DIOPT Version :9

Sequence 1:	NP_722789.1	Gene:	CG31681 / 318882	FlyBaseID:	FBgn0051681	Length:	264	Species:	Drosophila melanogaster
Sequence 2:	NP_775773.2	Gene:	PRSS36 / 146547	HGNCID:	26906	Length:	855	Species:	Homo sapiens

Alignment Length:	290	Identity:	94/290 - (32%)
Similarity:	135/290 - (46%)	Gaps:	41/290 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MCLRLLLSILVSIAG----------------LACAARIPGPEERIVGGSYIPIEYVPWQVSVQNN 49
            :.|.|::.::..|.|                |.|..  |.|..||||||.......|||||:.:.
Human     5 LLLPLVMLVISPIPGAFQDSALSPTQEEPEDLDCGR--PEPSARIVGGSNAQPGTWPWQVSLHHG 67

  Fly    50 SLHCCGGVIYSDRAILTAAHC-LSNVTV---TDLSVRAG--SSYWSKGGQVLKVLKTIAHPKYVP 108
            ..|.|||.:.:...:|:|||| ::|.|:   .:.||..|  |......|...:.:..|..|....
Human    68 GGHICGGSLIAPSWVLSAAHCFMTNGTLEPAAEWSVLLGVHSQDGPLDGAHTRAVAAIVVPANYS 132

  Fly   109 KLYNPYDIAVLILEAPLRLGGTVKKI--PLAEQTPVAGTIVLTSGWGYTRENSSFLWP-ILQGVH 170
            ::....|:|:|.|.:|..||..|..:  |.|....|.||....:|||..:|......| :||.|.
Human   133 QVELGADLALLRLASPASLGPAVWPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVE 197

  Fly   171 VAILNRTDCLKAYKH---VNITID----MICA---DGQRWDTCQGDSGGPLIETTKGGHRQLIGM 225
            :.:|....|...|..   .|:|:.    |:||   :|:| |||||||||||: ..:||.....|:
Human   198 LRLLGEATCQCLYSQPGPFNLTLQILPGMLCAGYPEGRR-DTCQGDSGGPLV-CEEGGRWFQAGI 260

  Fly   226 VSWGDGCG--TNPGVYEDIAFFHNWIKYTV 253
            .|:|.|||  ..|||:..:|.:..||:..|
Human   261 TSFGFGCGRRNRPGVFTAVATYEAWIREQV 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31681	NP_722789.1	Tryp_SPc	28..249	CDD:214473	83/241 (34%)
CG31681	NP_722789.1	Tryp_SPc	29..250	CDD:238113	83/241 (34%)
PRSS36	NP_775773.2	Tryp_SPc	46..286	CDD:214473	83/241 (34%)
		Tryp_SPc	47..289	CDD:238113	84/243 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..316
		Tryp_SPc	330..538	CDD:304450
		Tryp_SPc	601..783	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149407
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24276
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030