DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34126 and Uhrf1bp1l

DIOPT Version :9

Sequence 1:	NP_001260066.1	Gene:	CG34126 / 318872	FlyBaseID:	FBgn0083962	Length:	1518	Species:	Drosophila melanogaster
Sequence 2:	NP_083442.2	Gene:	Uhrf1bp1l / 75089	MGIID:	2442888	Length:	1457	Species:	Mus musculus

Alignment Length:	1685	Identity:	459/1685 - (27%)
Similarity:	708/1685 - (42%)	Gaps:	465/1685 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVSLIKNQLLKHLSIYTKNLSSDKINLSTFRGEGELSNLELDERVLTELLELPSWLRLTSAWCNH 65
            |..:||.|:|||||.:|||||.|||||||.:|||||.||||||.||..:|:||:||.::..:||.
Mouse     1 MAGIIKKQILKHLSRFTKNLSPDKINLSTLKGEGELKNLELDEEVLQNMLDLPTWLAISKVFCNK 65

  Fly    66 VSFRISWTKLKSVPITLTLDEVRITIETCNPTTRDAGGGSGAGGAGSPTAAASAALPQVPQGKYS 130
            .|.||.|||||:.||.|:||:|.:.:.||....        |....||.|.||.      |.:|.
Mouse    66 ASIRIPWTKLKTQPICLSLDKVIMEMSTCEEPR--------APNGPSPIATASG------QSEYG 116

  Fly   131 FIHKVVDGITIVVNTVNVNFVSAAFTASVQMSRIRVESKTPKWANADLRLTRLKDAQKGIILIFK 195
            |..|||:|||:.||::.:...:.||.||.::|::|:.|...:|.:.|||.||::|.|:|.:|.||
Mouse   117 FAEKVVEGITVSVNSIVIRIGAKAFNASFELSQLRIYSVNAQWEHGDLRFTRIQDPQRGEVLTFK 181

  Fly   196 ELSWQTVRIEASSTQDKSL----TPLRLLTNHARCRITIRKRLSDCSLLASRLVLILDDLLWVLT 256
            |::||.:||||.:||...|    .|:||:||.::.|:|:::||.||:::|::|||||||||||||
Mouse   182 EINWQMIRIEADATQSSHLEIMCAPVRLITNQSKIRVTLKRRLKDCNVIATKLVLILDDLLWVLT 246

  Fly   257 DSQLKAALHFVDSLSGLIKAATHATQKTKAARKMQTLPEYKAQVEQQQNRLSESA-HTTNAQ--- 317
            ||||||.:.:..|||       .|.:|:...||... ||     ..|.:.::.|| |....|
Mouse   247 DSQLKAMVQYAKSLS-------EAIEKSTEQRKSMA-PE-----PTQSSTVTSSAQHVKTPQAAN 298

  Fly   318 ---------RMFNAFDVRETSYHFFSQRIDLHLCDD------EGDGRSSYPDLDKGGALQVSVTA 367
                     ::||.|||:|||:|.....:|||:|||      |.:.|.|      |||:|:|.|.
Mouse   299 APDLSDAIVKLFNDFDVKETSHHLVISHLDLHICDDIHAKEKESNRRVS------GGAMQLSFTQ 357

  Fly   368 FQVDYYPYHLAKSDRSHWAKYKEASVAPALWLKESLNAF-------REAV--LNLSQPNRPATHA 423
            ..:||||||.|....|||..:.:|:.....|..|.|:.|       ::|:  .||..|.:..||
Mouse   358 LTIDYYPYHKAGDSCSHWMYFSDATKTKNGWANELLHEFECNVEMLKQAMKDRNLGSPPKSPTH- 421

  Fly   424 PLERSTPASPIMLSASMLGSQHGAGSFSNGSSTPTAAGLAAGSGGSAGSGTASMNSQFSQAAQQR 488
                   |||          ||          |.|       ...|...||....|...|.::
Mouse   422 -------ASP----------QH----------TQT-------EKDSTLKGTPKTPSVLPQPSK-- 450

  Fly   489 STLENLAKLMSSCVILRIEDFTLYRVTTSGK-KAMPKEFVSGDKDRYSFPAEMPIIHAEYTYFYY 552
                  ||||||.|::|:.||.:|:|:|:.: ::.||..:|.:|.....|.||..|:.|:|.:||
Mouse   451 ------AKLMSSSVVVRLADFNIYQVSTAEQCRSSPKSMISCNKKSLYLPQEMSAIYIEFTEYYY 509

  Fly   553 PGDFVFPLPPSKVFVHVNPIQVHFDLSSILWLNSFGLNLHESL------LRTSVGSQSTLHPQQQ 611
            |....||:|...::..:|.:|...|..||||||.|.|:|.:||      .:.:..|:|..|
Mouse   510 PDGKDFPIPSPNLYSQLNALQFTVDERSILWLNQFLLDLKQSLNQFMAVYKLNDSSKSDEH---- 570

  Fly   612 LPRGSIASNGSNGTQMAAVNVEQEPNLMYMDVKVEAIMPRIVMEAALDAPSQKDRPKTMQIQVSR 676
                                         :|::|:.:|.:.|:.:.:.|...:|:|.|:.||.|.
Mouse   571 -----------------------------VDIRVDGLMLKFVIPSEVKAGCHQDQPHTVSIQSSE 606

  Fly   677 FALTNIREMGSSR-ADLAQALHSLQEGSLVFG---SGFPSKEGDMCIVTDRILSHVAASDVSMMS 737
            ...||.|...:.| :||.......:|... |.   :.||.......::......|....|..|..
Mouse   607 MIATNTRHCPNCRHSDLEALCQDFKECDF-FSKTYTRFPKSCDSFNLLHPIFQRHAHEQDTKMHE 670

  Fly   738 PVSPTGQQLPR--------SASTQYLSRYVMWLEPRDVWCIKLDPVWVDFLGARSLGPNKSIPFV 794
            ...  |..:|:        ||:|             |||.:.....|:|:.|.:| |..:.:.||
Mouse   671 VYK--GNIIPKLNKNTLKTSAAT-------------DVWAVYFSQFWIDYEGMKS-GKGRPVSFV 719

  Fly   795 DAVPITLWLHSGSAQAQL---------------DVGKSGTAGSME---------SMGMPPLPTLP 835
            ||.|:::|:...:..|:|               ....|..||.|:         |....|| |..
Mouse   720 DAFPLSIWICQPTRYAELQKEFQTCDQVTLNTSQSESSDLAGRMKRKKLLKEYYSTESEPL-TNG 783

  Fly   836 PLQPCNPFLSDEDVRLAGVASGASPPAPAPDRTADVHAIAHISNLVSLQIDHYQLLFLLRLAEEL 900
            ..:|.    ||..:|.:..:|           .||||.:..:...||:||:|||.|.||.:.|.|
Mouse   784 GQRPS----SDTFLRFSSSSS-----------DADVHVLVRVHKHVSMQINHYQYLLLLFIHESL 833

  Fly   901 NEMSTFLNLDAERILQKQNEQKSIIFGCVVPQIEVTLVM--PSPTPGKESSGGDAES-VVPDSAS 962
            ..:|..|..|.|.::.....|.|:..|.::...|:.|::  .:||....|...::.| ::||..
Mouse   834 VLLSDTLRRDVEAVIGSPASQTSVCVGILLRSAELALLLHPVNPTSALRSPASESGSPLLPDFL- 897

  Fly   963 LGDDLHMNSGNITWPTPPPLDQLKSNTFGSVETPSPVTNEPPFDNGIHISNPNTHGYNVQIQSTP 1027
                                                     |.:||..:|:....|
Mouse   898 -----------------------------------------PAENGGFLSSKRKQG--------- 912

  Fly  1028 TMASSTASQGS-----RPDTGISTQSQSQTQSISSASKSAKSAAARSGATDT------------- 1074
                     ||     |..| ::..|.:::.|:..:....|.......|:||
Mouse   913 ---------GSGIHRIRNAT-LNHMSDNRSMSVDLSHAPLKDPLLFKSASDTNLQKGTSFLDYLS 967

  Fly  1075 ---VPSLTKEINSGLLSMKKGFSSFMTSIDSAIK--SGTPNDDASDTFSIQSDISSDSDNFAN-- 1132
               :..::::.:|| ||.|.| |..|||..|..|  :.|.:|...:.....:.:|.|.|...|
Mouse   968 DKHLGKISEDESSG-LSHKSG-SGEMTSEGSHTKDVASTDSDSVLNYRDGSTRLSLDDDGNHNPP 1030

  Fly  1133 ---VLGDDKTMDCMDVMFRLNPFTTD--------------------------------------- 1155
               |.|  |.:|.:..:||...|..:
Mouse  1031 SNPVTG--KGIDAIHSIFRAEDFLPEAASLSENPESSKEEAPPARAPKSQTSLSAKSKERCPPSP 1093

  Fly  1156 --------NMKASPVEVA-------SEVYEEQPSS----------------YKTNMSSPSEP--- 1186
                    |||.|..:|:       |.|.|||..|                ..|:..||:|.
Mouse  1094 APLSVSYKNMKRSASQVSLDTLSLDSMVLEEQAESDGSDSHVLLGKAMKRNSNTSCQSPAESVNT 1158

  Fly  1187 ------------------SEGSTWRRRDLVSMATFRLTTVELIRQQEGPKSSVRLQVAAVSCDEC 1233
                              |||:...|.||:|:..||:|.|.......|..:.|.|||..|:..:.
Mouse  1159 SANTQTCGEASPEAVSTNSEGTQENRDDLMSVVVFRITGVNGEIDIRGEDTEVCLQVNQVTPSQL 1223

  Fly  1234 GAIPWDELQIARQANKTKFGARCKAWNLAPYNPEAPPCIRMRLEE-----TLNMPKEIEGIIDRK 1293
            |     .:.:.........|:..|    |..:|::.|.|.:|.|.     ..::..|..|.:
Mouse  1224 G-----NVSLRHYLGNRPVGSDQK----AIIHPKSSPEISLRFESGPGAVVHSLLAEKNGFL--- 1276

  Fly  1294 RIQSWITHHAEIRVKDINMDLSMSTVIGLGDLAEDEVISPPMPLTVNLENVRINLLEDRPPVNIT 1358
                      :..:::...:...|:::.:....|||.::..||:.:.:.|.:|||.:|.|..:..
Mouse  1277 ----------QCHIENFTTEFLTSSLLNIQHFLEDETVATVMPMKIQVSNTKINLKDDSPRGSTV 1331

  Fly  1359 SPGPIPINLCIGRMRLERDQSGLLNIQPIDTNM------------SDA-----------QHQALG 1400
            |..|.|:.:.|.|:.:||...|..:|:  |:::            ||:           .|.::.
Mouse  1332 SLQPSPVTVHIDRLVVERSDDGSFHIR--DSHLFNTGTDFKDGASSDSVVRTRGMCDVRMHSSVT 1394

  Fly  1401 SALFGAPRE--RDRELLSMQLVMQQMKLDNDQLRRQLVDSKVN-------TDNYRHKTKQ 1451
            .|...:|..  ..:....:.:..:|:..:|:.||::|..:|:.       .|...|:.|:
Mouse  1395 QATQTSPEVPLPSQSANFLDITREQLMEENECLRQRLAQAKMELAEAHSARDELLHQMKR 1454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34126	NP_001260066.1	Chorein_N	3..98	CDD:289396	56/94 (60%)
Uhrf1bp1l	NP_083442.2	Chorein_N	3..>87	CDD:289396	53/83 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..295		8/33 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	409..449		17/74 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	975..1038		20/66 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1056..1099		0/42 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1145..1183		7/37 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	423	1.000	Domainoid score	I621
eggNOG	1	0.900	-	-		E1_KOG2955
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12590
Inparanoid	1	1.050	532	1.000	Inparanoid score	I1194
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003027
OrthoInspector	1	1.000	-	-		otm43315
orthoMCL	1	0.900	-	-		OOG6_104536
Panther	1	1.100	-	-	O	PTHR22774
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3217
SonicParanoid	1	1.000	-	-		X2376
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.850