DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34126 and UHRF1BP1

DIOPT Version :9

Sequence 1:	NP_001260066.1	Gene:	CG34126 / 318872	FlyBaseID:	FBgn0083962	Length:	1518	Species:	Drosophila melanogaster
Sequence 2:	NP_060224.3	Gene:	UHRF1BP1 / 54887	HGNCID:	21216	Length:	1440	Species:	Homo sapiens

Alignment Length:	1625	Identity:	432/1625 - (26%)
Similarity:	694/1625 - (42%)	Gaps:	357/1625 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVSLIKNQLLKHLSIYTKNLSSDKINLSTFRGEGELSNLELDERVLTELLELPSWLRLTSAWCNH 65
            |..:||.|:|||||.:|||||.|||||||.:|||:|:||||||.||..:||||:||.:|..:||.
Human     1 MAGIIKKQILKHLSRFTKNLSPDKINLSTLKGEGQLTNLELDEEVLQNVLELPTWLAITRVYCNR 65

  Fly    66 VSFRISWTKLKSVPITLTLDEVRITIETCNPTTRDAGGGSGAGGAGSPTAAASAALPQVPQGKYS 130
            .|.||.|||||:.||.|.||:|.:.::||.......|        .||.|.||.      |.:|.
Human    66 ASIRIQWTKLKTHPICLCLDKVEVEMKTCEDPRPPNG--------QSPIALASG------QSEYG 116

  Fly   131 FIHKVVDGITIVVNTVNVNFVSAAFTASVQMSRIRVESKTPKWANADLRLTRLKDAQKGIILIFK 195
            |..|||:|:.|:||::.:...|.||.||.::.:::..|..|.|..:||||||:.|..:|.:|.||
Human   117 FAEKVVEGMFIIVNSITIKIHSKAFHASFELWQLQGYSVNPNWQQSDLRLTRITDPCRGEVLTFK 181

  Fly   196 ELSWQTVRIEASST----QDKSLTPLRLLTNHARCRITIRKRLSDCSLLASRLVLILDDLLWVLT 256
            |::|||:||||.:|    ||...|||||:||..|.:|.:::|..||::::|:|:.:|||||||||
Human   182 EITWQTLRIEADATDNGDQDPVTTPLRLITNQGRIQIALKRRTKDCNVISSKLMFLLDDLLWVLT 246

  Fly   257 DSQLKAALHFVDSLSGLIKAATHATQKTKAARKMQ-TLPEYKAQVEQQQ----NRLSESAHTTNA 316
            ||||||.:.:.:|||..::.:.| .:|:.|...:| |.|...||....|    ::.:.::.::..
Human   247 DSQLKAMMKYAESLSEAMEKSAH-QRKSLAPEPVQITPPAPSAQQSWAQAFGGSQGNSNSSSSRL 310

  Fly   317 QRMFNAFDVRETSYHFFSQRIDLHLCDDEGDGRSSYPDLD----KGGALQVSVTAFQVDYYPYHL 377
            .:.|..|||:|:|||....|:|||:||   |.:|..|.:.    .|||:|::......||||:|.
Human   311 SQYFEKFDVKESSYHLLISRLDLHICD---DSQSREPGVSANRLMGGAMQLTFRKMAFDYYPFHW 372

  Fly   378 AKSDRSHWAKYKEASVAPALWLKESL-------------------------NAFREAVLNLSQPN 417
            |.....||.::.||......|.::.:                         :.||....:||.|.
Human   373 AGDSCKHWVRHCEAMETRGQWAQKLVMEFQSKMEKWHEETGLKPPWHLGVDSLFRRKADSLSSPR 437

  Fly   418 RPATHAPLERSTPASPIMLSASMLGSQHGAGSFSNGSSTPTAAGLAAGSGGSAGSGTASMNSQFS 482
            :    .|||||.                                                 ||..
Human   438 K----NPLERSP-------------------------------------------------SQGR 449

  Fly   483 QAAQQRSTLENLAKLMSSCVILRIEDFTLYRVTTSGKKA-MPKEFVSGDKDRYSFPAEMPIIHAE 546
            |.|.|.....   :|.|||:::|::|..:::|:|:|:.: .|...:|..:..::.|.::..||.|
Human   450 QPAFQPPAWN---RLRSSCMVVRVDDLDIHQVSTAGQPSKKPSTLLSCSRKLHNLPTQVSAIHIE 511

  Fly   547 YTYFYYPGDFVFPLPPSKVFVHVNPIQVHFDLSSILWLNSFGLNLHESLLRTSVGSQSTLHPQQQ 611
            :|.:|:|.:...|:|...:::.:|.:....|..|:||.|.|.|:|:.||
Human   512 FTEYYFPDNQELPVPCPNLYIQLNGLTFTMDPVSLLWGNLFCLDLYRSL---------------- 560

  Fly   612 LPRGSIASNGSNGTQMAAVNVEQEPNLM--YMDVKVEAIMPRIVMEAALDAPSQKDRPKTMQIQV 674
                         .|..|:...::.:..  ::|::::|...::.........::..||:.:....
Human   561 -------------EQFKAIYKLEDSSQKDEHLDIRLDAFWLKVSFPLEKRERAELHRPQALVFSA 612

  Fly   675 SRFALTNIREM-GSSRADL---------AQALHSLQEGSLVFGSGFPSKEGDMCIVTDRILSHVA 729
            |....||.|.. ..|.:||         |:..||..:       .||...|...::....|.|..
Human   613 SGMIATNTRHAPHCSCSDLQSLFRGFAAAEFFHSNYD-------HFPKVPGGFSLLHMLFLHHAF 670

  Fly   730 ASDVSMMSPVSPTGQQLPRSASTQYLSRYVMWLEPRDVWCIKLDPVWVDFLGARSLGPNKSIPFV 794
            ..|..:..| :....|.|:::          |    |:|.:....:.:||.|..:. ...::.||
Human   671 QMDSCLPQP-NTLPPQRPKAS----------W----DLWSVHFTQISLDFEGTENF-KGHTLNFV 719

  Fly   795 DAVPITLW----LHSGSAQA-QLDVGKSGTAGSMESMGMP-PLPTLPPLQPCNP-FLSDEDVR-L 851
            ...|:::|    |....||| :|.:...|......|.|.| ....|.|....:| ..::.|:: |
Human   720 APFPLSIWACLPLRWQQAQARKLLLASEGRLKPSASFGSPVQSEALAPDSMSHPRSKTEHDLKSL 784

  Fly   852 AGV----------ASGASPPAPAP--DRTADVHAIAHISNLVSLQIDHYQLLFLLRLAEELNEMS 904
            :|:          :||.....|..  :..||||.:.|....|.:::||||.|.||||.|.|..:.
Human   785 SGLTEVMEILKEGSSGMDNKGPLTELEDVADVHMLVHSPAHVRVRLDHYQYLALLRLKEVLQRLQ 849

  Fly   905 TFLNLDAERILQKQNEQKSIIFGCVVPQIEVTLVMPSPTPG---KESSGGDAESVVPDSASLGDD 966
            ..|..|.|.:.....:.::...|.:.|..||.|:| .|.||   .:|:|.|:.|:|....|..:|
Human   850 EQLTKDTESMTGSPLQNQTACIGVLFPSAEVALLM-HPAPGAVDADSAGSDSTSLVDSELSPSED 913

  Fly   967 LHMNSGNITWPTPPPLDQLKSNTFGSVETPSPVTNEPPFDNGIHISNPNTHGYNVQIQSTPTMAS 1031
            ..:.|...:...|...:::...:  |:|. ..|:.|.|..||             ::|.:..:|.
Human   914 RELKSDASSDQGPASPEKVLEES--SIEN-QDVSQERPHSNG-------------ELQDSGPLAQ 962

  Fly  1032 STASQGSRPDTGISTQSQSQTQSISSASKSAKSAAARSGATDTVPSLTKEINSGLLSMKKGFSSF 1096
            ..|.:|......:..:..|:||: ||:..:.|..|.|..|.:         ..|.|...|.....
Human   963 QLAGKGHEAVESLQAKKLSRTQA-SSSPAALKPPAGRETAVN---------GQGELIPLKNIEGE 1017

  Fly  1097 MTSIDSAIKSGTPNDDASDTFSIQSD-ISSDSDNFANVLGDDKTMDCMDVMFRLNP-----FTTD 1155
            ::|.....|..| .:....|..:..: :|...|.|:  ||.|:....|..|..|.|     ..||
Human  1018 LSSAIHMTKDAT-KEALHATMDLTKEAVSLTKDAFS--LGRDRMTSTMHKMLSLPPAKEPMAKTD 1079

  Fly  1156 NMKASPVE--------------VASEVY----------------------------------EEQ 1172
            ...|:||.              |:.:.:                                  |..
Human  1080 EGVAAPVSGGAARLRFFSMKRTVSQQSFDGVSLDSSGPEDRISVDSDGSDSFVMLLESESGPESV 1144

  Fly  1173 PSSYKTNMS-----------------SPSEPSEGSTWRRRDL----VSMATFRLTTVELIRQQEG 1216
            |....:|:|                 ||:..|..|. ...||    ||:...::..|....:..|
Human  1145 PPGSLSNVSDNAGVQGSPLVNNYGQGSPAANSSVSP-SGEDLIFHPVSVLVLKVNEVSFGIEVRG 1208

  Fly  1217 PKSSVRLQVAAVSCDECGAIP-WDELQ------IARQANKTKFGARCKAWNLAPYNPEAPPCIRM 1274
            ...:|.||...::..:.|.:. |..|.      ..::::..|.|             ...|.:.:
Human  1209 EDLTVALQAEELTLQQLGTVGLWQFLHGQCPGTCFQESSTLKTG-------------HIRPAVGL 1260

  Fly  1275 RLE----ETLNMPKEIEGIIDRKRIQSWITHHAEIRVKDINMDLSMSTVIGLGDLAEDEVISPPM 1335
            |.|    ..::.|         ...|:...|   :.:...:::|..|.:.|||...|||.|...:
Human  1261 RFEVGPGAAVHSP---------LASQNGFLH---LLLHGCDLELLTSVLSGLGPFLEDEEIPVVV 1313

  Fly  1336 PLTVNLENVRINLLEDRPPVNITSPGPIPINLCIGRMRLERDQSGLLNIQPIDTNMSDAQHQALG 1400
            |:.:.|.|..|.|.:|.||:..||||||||.|.:..:.|:|...|:.:|.      :.||.:...
Human  1314 PMQIELLNSSITLKDDIPPIYPTSPGPIPITLAMEHVVLKRSDDGVFHIG------AAAQDKPSA 1372

  Fly  1401 SALFGAPRERDRE---LLSMQLVMQQMKLDNDQLRRQLVDSK---VNTDNYRHKTKQEADVLRSY 1459
            ..|....|:..:|   |:....|.:|...:...|:::|:::|   .|.:..:.|..||   :|.|
Human  1373 EVLKSEKRQPPKEQVFLVPTGEVFEQQVKELPILQKELIETKQALANANQDKEKLLQE---IRKY 1434

Fly 1460 1459
Human 1435 1434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34126	NP_001260066.1	Chorein_N	3..98	CDD:289396	57/94 (61%)
UHRF1BP1	NP_060224.3	Chorein_N	3..>89	CDD:289396	55/85 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..307		9/40 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	430..456		13/78 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	751..780		6/28 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	891..1008		30/142 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1106..1180		7/73 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160134
Domainoid	1	1.000	415	1.000	Domainoid score	I664
eggNOG	1	0.900	-	-		E1_KOG2955
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	523	1.000	Inparanoid score	I1261
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41579at33208
OrthoFinder	1	1.000	-	-		FOG0003027
OrthoInspector	1	1.000	-	-		otm41256
orthoMCL	1	0.900	-	-		OOG6_104536
Panther	1	1.100	-	-	LDO	PTHR22774
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3217
SonicParanoid	1	1.000	-	-		X2376
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790