Protein Alignment CG34126 and BLTP3B

DIOPT Version :10

• Sequence 1: NP_001260066.1
• Gene: CG34126 / 318872
• FlyBaseID: FBgn0083962
• Length: 1518
• Species: Drosophila melanogaster
• Sequence 2: NP_055869.1
• Gene: BLTP3B / 23074
• HGNCID: 29102
• Length: 1464
• Species: Homo sapiens
• Alignment Length: 1719
• Identity: 454/1719 - (26%)
• Similarity: 710/1719 - (41%)
• Gaps: 487/1719 - (28%)

  Fly     1 MVSLIKNQLLKHLSIYTKNLSSDKINLSTFRGEGELSNLELDERVLTELLELPSWLRLTSAWCNH 65
            |..:||.|:|||||.:|||||.|||||||.:|||||.||||||.||..:|:||:||.:...:||.
Human     1 MAGIIKKQILKHLSRFTKNLSPDKINLSTLKGEGELKNLELDEEVLQNMLDLPTWLAINKVFCNK 65

  Fly    66 VSFRISWTKLKSVPITLTLDEVRITIETCNPTTRDAGGGSGAGGAGSPTAAASAALPQVPQGKYS 130
            .|.||.|||||:.||.|:||:|.:.:.||.......|        .||.|.||.      |.:|.
Human    66 ASIRIPWTKLKTHPICLSLDKVIMEMSTCEEPRSPNG--------PSPIATASG------QSEYG 116

  Fly   131 FIHKVVDGITIVVNTVNVNFVSAAFTASVQMSRIRVESKTPKWANADLRLTRLKDAQKGIILIFK 195
            |..|||:||::.||::.:...:.||.||.::|::|:.|....|.:.|||.||::|.|:|.:|.||
Human   117 FAEKVVEGISVSVNSIVIRIGAKAFNASFELSQLRIYSVNAHWEHGDLRFTRIQDPQRGEVLTFK 181

  Fly   196 ELSWQTVRIEASSTQDKSL----TPLRLLTNHARCRITIRKRLSDCSLLASRLVLILDDLLWVLT 256
            |::||.:||||.:||...|    .|:||:||.::.|:|:::||.||:::|::|||||||||||||
Human   182 EINWQMIRIEADATQSSHLEIMCAPVRLITNQSKIRVTLKRRLKDCNVIATKLVLILDDLLWVLT 246

  Fly   257 DSQLKAALHFVDSLSGLIKAATHATQKTKAARKMQ--TLPEYKAQVEQQQNRLSESAHTTNAQ-- 317
            ||||||.:.:..|||..|:.:|. .:|:.|....|  |:.....||:..|        |:||.
Human   247 DSQLKAMVQYAKSLSEAIEKSTE-QRKSMAPEPTQSSTVVASAQQVKTTQ--------TSNAPDV 302

  Fly   318 -----RMFNAFDVRETSYHFFSQRIDLHLCDD------EGDGRSSYPDLDKGGALQVSVTAFQVD 371
                 ::||.|||:|||:|.....:|||:|||      |.:.|.:      |||:|:|.|...:|
Human   303 NDAIVKLFNDFDVKETSHHLVISHLDLHICDDIHAKEKESNRRIT------GGAMQLSFTQLTID 361

  Fly   372 YYPYHLAKSDRSHWAKYKEASVAPALWLKESLNAF-------REAVL--NLSQPNRPATHAPLER 427
            |||||.|....:||..:.:|:.....|..|.|:.|       ::||.  |:..|.:..||
Human   362 YYPYHKAGDSCNHWMYFSDATKTKNGWANELLHEFECNVEMLKQAVKDHNVGSPPKSPTH----- 421

  Fly   428 STPASPIMLSASMLGSQHGAGSFSNGSSTPTAAGLAAGSGGSAGSGTASMNSQFSQAAQQRSTLE 492
               |||          ||          |.|......       .||....|..||        :
Human   422 ---ASP----------QH----------TQTEKDYPL-------KGTCRTPSVLSQ--------Q 448

  Fly   493 NLAKLMSSCVILRIEDFTLYRVTTSGK-KAMPKEFVSGDKDRYSFPAEMPIIHAEYTYFYYPGDF 556
            :.||||||.|::|:.||.:|:|:|:.: ::.||..:..:|.....|.||..::.|:|.:|||...
Human   449 SKAKLMSSSVVVRLADFNIYQVSTAEQCRSSPKSMICCNKKSLYLPQEMSAVYIEFTEYYYPDGK 513

  Fly   557 VFPLPPSKVFVHVNPIQVHFDLSSILWLNSFGLNLHESLLRTSVGSQSTLHPQQQLPRGSIASNG 621
            .||:|...::..:|.:|...|..||||||.|.|:|.:||
Human   514 DFPIPSPNLYSQLNALQFTVDERSILWLNQFLLDLKQSL-------------------------- 552

  Fly   622 SNGTQMAAV-----NVEQEPNLMYMDVKVEAIMPRIVMEAALDAPSQKDRPKTMQIQVSRFALTN 681
               .|..||     |.:.:.   ::||:|:.:|.:.|:.:.:.:...:|:|:.:.||.|....||
Human   553 ---NQFMAVYKLNDNSKSDE---HVDVRVDGLMLKFVIPSEVKSECHQDQPRAISIQSSEMIATN 611

  Fly   682 IREMGSSRADLAQALHSLQEGSLVFG---SGFPSKEGDMCIVTDRILSHVAASDVSM----MSPV 739
            .|...:.|....:||....:....|.   :.||....:..::......|....|..|    ...:
Human   612 TRHCPNCRHSDLEALFQDFKDCDFFSKTYTSFPKSCDNFNLLHPIFQRHAHEQDTKMHEIYKGNI 676

  Fly   740 SP--TGQQLPRSASTQYLSRYVMWLEPRDVWCIKLDPVWVDFLGARSLGPNKSIPFVDAVPITLW 802
            :|  ....|..||:|             |||.:.....|:|:.|.:| |..:.|.|||:.|:::|
Human   677 TPQLNKNTLKTSAAT-------------DVWAVYFSQFWIDYEGMKS-GKGRPISFVDSFPLSIW 727

  Fly   803 LHSGSAQAQLDVGKSGTAGSMESMGMPPLPTLPPLQPCNPF----LSDEDVRLAG---------- 853
            :...:..|             ||...|        |.||..    ...|...|||
Human   728 ICQPTRYA-------------ESQKEP--------QTCNQVSLNTSQSESSDLAGRLKRKKLLKE 771

  Fly   854 --------VASGASPPAP-------APDRT-ADVHAIAHISNLVSLQIDHYQLLFLLRLAEELNE 902
                    :.:|...|:.       :|..: ||:|.:.|:...||:||:|||.|.||.|.|.|..
Human   772 YYSTESEPLTNGGQKPSSSDTFFRFSPSSSEADIHLLVHVHKHVSMQINHYQYLLLLFLHESLIL 836

  Fly   903 MSTFLNLDAERILQKQNEQKSIIFGCVVPQIEVTLVMPSPTPGKESSGGDAESVVPDSASLGDDL 967
            :|..|..|.|.:......|.||..|.::...|:.|:                            |
Human   837 LSENLRKDVEAVTGSPASQTSICIGILLRSAELALL----------------------------L 873

  Fly   968 HMNSGNITWPTPPPLDQLKSNTFGS--VETPSPVTNE-PPFDNGIHISNPNTHGYNVQIQSTPTM 1029
            |            |:||  :||..|  .|:.|||..: .|.:||                   ..
Human   874 H------------PVDQ--ANTLKSPVSESVSPVVPDYLPTENG-------------------DF 905

  Fly  1030 ASSTASQGSRP-----DTGISTQSQSQTQSISSASKSAKSAAARSGATDT--------------- 1074
            .||...|.||.     ...::..|.:::.|:..:....|.......|:||
Human   906 LSSKRKQISRDINRIRSVTVNHMSDNRSMSVDLSHIPLKDPLLFKSASDTNLQKGISFMDYLSDK 970

  Fly  1075 -VPSLTKEINSGLLSMKKGFSSFMTSIDSAIKSGTPNDDASDTFSIQSD-----------ISSDS 1127
             :..::::.:|||: .|.|....          |:...|..|:|...|.           :|.||
Human   971 HLGKISEDESSGLV-YKSGSGEI----------GSETSDKKDSFYTDSSSILNYREDSNILSFDS 1024

  Fly  1128 DNFANVLGD---DKTMDCMDVMFRLN---------------------PFTT-------------- 1154
            |...|:|..   .|..:.::.:|:..                     |..|
Human  1025 DGNQNILSSTLTSKGNETIESIFKAEDLLPEAASLSENLDISKEETPPVRTLKSQSSLSGKPKER 1089

  Fly  1155 ------------DNMKAS-------PVEVASEVYEEQ---------------------PSSYK-- 1177
                        .|||.|       .:.:.|.:.|||                     .::|:
Human  1090 CPPNLAPLCVSYKNMKRSSSQMSLDTISLDSMILEEQLLESDGSDSHMFLEKGNKKNSTTNYRGT 1154

  Fly  1178 ---------------TNMSSPSEPSEGSTWRRRDLVSMATFRLTTVELIRQQEGPKSSVRLQVAA 1227
                           |:..:.|..|||:.....||:|:..|::|.|.......|..:.:.|||..
Human  1155 AESVNAGANLQNYGETSPDAISTNSEGAQENHDDLMSVVVFKITGVNGEIDIRGEDTEICLQVNQ 1219

  Fly  1228 VSCDECGAIPWDELQIARQANKTKFGARCKAWNLAPYNPEAPPCIRMRLEETLNMPKEIEGIIDR 1292
            |:.|:.|     .:.:.........|:..||...:..:||    |.:|.|.  .....|..::..
Human  1220 VTPDQLG-----NISLRHYLCNRPVGSDQKAVIHSKSSPE----ISLRFES--GPGAVIHSLLAE 1273

  Fly  1293 KRIQSWITHHAEIRVKDINMDLSMSTVIGLGDLAEDEVISPPMPLTVNLENVRINLLEDRPPVNI 1357
            |  ..::..|    :::.:.:...|:::.:....|||.::..||:.:.:.|.:|||.:|.|..:.
Human  1274 K--NGFLQCH----IENFSTEFLTSSLMNIQHFLEDETVATVMPMKIQVSNTKINLKDDSPRSST 1332

  Fly  1358 TSPGPIPINLCIGRMRLERDQSGLLNIQPIDTNM----SDAQHQALGSALF-------------- 1404
            .|..|.|:.:.|..:.:||...|..:|:  |::|    :|.:......::.
Human  1333 VSLEPAPVTVHIDHLVVERSDDGSFHIR--DSHMLNTGNDLKENVKSDSVLLTSGKYDLKKQRSV 1395

  Fly  1405 --------GAP---RERDRELLSMQLVMQQMKLDNDQLRRQLVDSKVNTDNYRHKTKQEADVLRS 1458
                    |.|   :..:....|.....:|:..:|:.|:::|..:|:        ...||.:
Human  1396 TQATQTSPGVPWPSQSANFPEFSFDFTREQLMEENESLKQELAKAKM--------ALAEAHL--- 1449

  Fly  1459 YLKAAQDDISILLEEKKALLDTIRSLQVQ 1487
                          ||.|||..|:.:.|:
Human  1450 --------------EKDALLHHIKKMTVE 1464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34126	NP_001260066.1	Chorein_N	3..98	CDD:463646	56/94 (60%)
BLTP3B	NP_055869.1	Chorein_N	1..>96	CDD:463646	57/94 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	267..297		8/38 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	409..436		11/61 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1066..1089		2/22 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1164..1183		5/18 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1392..1413		2/20 (10%)