DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34126 and C44H4.4

DIOPT Version :9

Sequence 1:	NP_001260066.1	Gene:	CG34126 / 318872	FlyBaseID:	FBgn0083962	Length:	1518	Species:	Drosophila melanogaster
Sequence 2:	NP_510427.2	Gene:	C44H4.4 / 181552	WormBaseID:	WBGene00008094	Length:	996	Species:	Caenorhabditis elegans

Alignment Length:	1412	Identity:	320/1412 - (22%)
Similarity:	533/1412 - (37%)	Gaps:	451/1412 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVSLIKNQLLKHLSIYTKNLSSDKINLSTFRGEGELSNLELDERVLTELLELPSWLRLTSAWCNH 65
            |.|:|||||:||||.:||||..::|:|...:|..:|..:|::|.||||:|||||||::..|:|..
Worm     1 MTSIIKNQLVKHLSKFTKNLKPEQISLDVLKGNSKLQFIEINEDVLTEILELPSWLKIKRAFCTG 65

  Fly    66 VSFRISWTKLKSVPITLTLDEVRITIETCNPTTRDAGGGSGAGGAGSPTAAASAALPQVPQGKYS 130
            |:..:.|||||:.||.:.:||:.:.:|..|...:.| ..:..|..|..::             |.
Worm    66 VAVNVPWTKLKTCPIQIFIDEINVDVELTNEHKKQA-KSNPLGNLGDSSS-------------YG 116

  Fly   131 FIHKVVDGITIVVNTVNVNFVSAAFTASVQMSRIRVESKTPKWANA-DLRLTRLKDAQKGIILIF 194
            |::|:::.:::.:::|.:||.|..|..|..:.|:.|||::|.||.. |||.||:..::....|:|
Worm   117 FMNKIIENMSLYISSVEINFDSDVFGGSFMLQRLSVESRSPGWAQVKDLRQTRITCSETNRTLMF 181

  Fly   195 KELSWQTVRIEASSTQDKS------LTPLRLLTNHARCRITIRKRLSDCSLLASRLVLILDDLLW 253
            |:|||..:|||||:...|:      ..||||:|:..:.||.::|.::|.|::.:|:..||||:||
Worm   182 KQLSWHLLRIEASAKTSKNEQRSKINAPLRLITSGGKIRIALKKNVNDGSVIHARIQTILDDILW 246

  Fly   254 VLTDSQLKAALHFVDSLSGLIKAATHATQKTKAARKMQTLPEYKAQVEQQQNRLSESAHTTNAQR 318
            |.|..||::|:.|...::.|:|.:......|.::....  |..||...      |.:|..:....
Worm   247 VATLPQLRSAISFASYIAKLVKESQKNDVITTSSGNDN--PFMKAAGN------SATADASTISS 303

  Fly   319 MFNAFDVRETSYHFFSQRIDLHLCDDEGDGRSSYPDLD-KGGALQVSVTAFQVDYYPYHLAKSDR 382
            .:|.|...:||||...::||||||||........||.| :.||:||::....:|.||...|:|||
Worm   304 AYNIFYFDQTSYHLHVKKIDLHLCDDAHTASDYPPDWDIESGAMQVTLYQVLIDVYPKAHAQSDR 368

  Fly   383 SHWAKYKEASVAPALWLKESLNAFREAVLNLSQPNRPATHAPLERSTPASPIMLSASMLGSQHGA 447
            |.|.:|...:.. |.|.:..|:  .:.:..|.......|...|||..|
Worm   369 STWMRYSNTNPI-AAWFRNHLS--EQFLTLLGNAEGQTTRTRLERCWP----------------- 413

  Fly   448 GSFSNGSSTPTAAGLAAGSGGSAGSGTASMNSQFSQAAQQRSTLENLAKLMSSCVILRIEDFTLY 512
                                                            :|:...|:||:.|.|:.
Worm   414 ------------------------------------------------QLIGFFVVLRVHDLTIQ 430

  Fly   513 RVT--TSGKKAMPKEFVSGDKDRYSFPAEMPIIHAEYTYFYYPGDFVFPLPPSKVFVHVNPIQVH 575
            .|:  .:.|.|:...|.| ::..:|.|::..|:|.|:..||:|.....|:|.|.|:..:.|..:.
Worm   431 CVSDMNTKKDALTNLFES-ERHLHSLPSDQQIVHVEFGAFYHPHSDKLPVPNSAVYFQLGPFTIS 494

  Fly   576 FDLSSILWLNSFGLNLHESLLRTSVGSQSTLHPQQQLPRGSIASNGSNGTQMAAVNVEQEPNLMY 640
            ||..::.|.      .:.:...:|......|.|:.:|.                   .|.|.
Worm   495 FDERTMRWC------CYVAHALSSAIEDGNLIPENELD-------------------IQPPT--- 531

  Fly   641 MDVKVEAIMPRIVMEAALDAP-SQKDRPKTMQIQVSRFALTNIREMGSSRADLAQALHSLQEGSL 704
              :||..:|||:|:.  |..| :..:.|:.:...:|..:::      ||:.|..:
Worm   532 --IKVNLVMPRLVLN--LPGPFTDFNFPRRLVTSMSTLSIS------SSQIDFKE---------- 576

  Fly   705 VFGSGFPSKEGDMCIVTDRILSHVA--ASDVSMMSPVSPTGQQLPRSASTQYLSRYVMWLEPRDV 767
              .|.|            ||||...  .|||.         .||....:..::
Worm   577 --NSRF------------RILSESTDEHSDVK---------NQLINGLNKFHI------------ 606

  Fly   768 WCIKLDPVWVDFLGARSLGP-NKSIPFVDAVPITLWLHSGSAQAQLDVGKSGTAGSMESMGMPPL 831
             |  ..|||::.    ..|| .|..||         ||..|....|.:.|......:|
Worm   607 -C--TSPVWIEI----DHGPQTKGFPF---------LHDVSFNGILAIDKDKVNVLVE------- 648

  Fly   832 PTLPPLQPCNPFLSDEDVRLAGVASGASPPAPAPDRTADVHAIAHISNLVSLQIDHYQLLFLLRL 896
                                           ||.|              |::.:||||.|.|.||
Worm   649 -------------------------------PAED--------------VAVVVDHYQFLQLTRL 668

  Fly   897 AEELNEMSTFLNLDAERILQKQNEQKS---IIFGCVVPQIEVTLVMPSPTPGKESSGGDAESVVP 958
            .::..:....|.||.:.  ...|:.||   :.|...:.:|.:.:|:   |.|:.:|        |
Worm   669 GDKFTKFLDQLTLDMKH--YNTNKPKSDVTVDFLASIARIRLYIVL---TMGEIAS--------P 720

  Fly   959 -DSASLGDDLHMNSGNITWPTPPPLDQLKSNTFGSVETPSPVTNEPPFDNGIHISNPNTHGYNVQ 1022
             |||::.:..|..           :|:|     ..:.:...:||...|.|...|.         .
Worm   721 YDSAAMSNFNHSF-----------MDRL-----SDIASTKSITNAHSFSNVNEIK---------V 760

  Fly  1023 IQSTPTMASSTASQGSRPDTGISTQSQSQTQSISSASKSAKSAAARSGATDTVPSLTKEINSGLL 1087
            |...|...:.||:....|:                        ..|.|    :.:.|.|:
Worm   761 INEQPRRTNKTATPEEFPE------------------------FPRGG----IDNDTSEV----- 792

  Fly  1088 SMKKGFSSFMTSI-DSAI--KSGTPNDD-------ASDTFSIQSDISSDSDNFANVLGDDKTMDC 1142
                  :|..||| |.||  .|..|:||       |.:..:|.....:|. .|.:.:.....:..
Worm   793 ------ASIATSIEDEAIYDLSEMPSDDPFGIPEYADEAITIDEPAINDR-TFRHTMAKQANLFM 850

  Fly  1143 MDVMFRLNPFTTDNMKASPVEVASEVYEEQPSSYKTNMSSPSEPSEGSTWRRRDLVSMATFRLTT 1207
            :         |.:::|     :|..|.||                                   |
Worm   851 V---------TLEDLK-----LAGNVVEE-----------------------------------T 866

  Fly  1208 VELIRQQEGPKSSVRLQVAAVSCDE----CGAIPWDELQI-ARQANKTKFGARCKAWNLAPYNPE 1267
            :::..|.:..:.|.:|.:.....::    .|:.|.|..:: ...|....|        |||.|.:
Worm   867 LKIDGQLKNIQLSEKLGIVRSEINDMMKKTGSEPLDLSKLPPTYAAAFSF--------LAPANEK 923

  Fly  1268 APPCIRMRLEETLNMPKEIEGIIDRKRIQSWITHHAEIRVKDINMDLSMSTVIGLGDLAEDEVIS 1332
                                            ..|..:.|..:...:....:..||..|:|:||:
Worm   924 --------------------------------VSHVTVDVNQLKATIDDEIIAHLGAFAKDDVIT 956

  Fly  1333 P-PMPLTVNLENVRINLLEDRPPVNITSPGPIPINLCIGRMRLERDQ 1378
            . .:.|.|.:.:..|.:::.:...        |:.:.|..|.:|:|:
Worm   957 ENRLRLAVLVHDSCIQIVDKKKKK--------PLRMKIQAMTIEQDE 995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34126	NP_001260066.1	Chorein_N	3..98	CDD:289396	45/94 (48%)
C44H4.4	NP_510427.2	MRS6	3..>214	CDD:227376	85/224 (38%)
C44H4.4	NP_510427.2	Chorein_N	3..96	CDD:372231	44/92 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167635
Domainoid	1	1.000	103	1.000	Domainoid score	I4262
eggNOG	1	0.900	-	-		E1_KOG2955
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41579at33208
OrthoFinder	1	1.000	-	-		FOG0003027
OrthoInspector	1	1.000	-	-		oto18532
orthoMCL	1	0.900	-	-		OOG6_104536
Panther	1	1.100	-	-	LDO	PTHR22774
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3217
SonicParanoid	1	1.000	-	-		X2376
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.740