DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zdhhc8 and AKR2

DIOPT Version :9

Sequence 1:	NP_001259382.1	Gene:	Zdhhc8 / 31887	FlyBaseID:	FBgn0085478	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_014677.1	Gene:	AKR2 / 854199	SGDID:	S000005560	Length:	749	Species:	Saccharomyces cerevisiae

Alignment Length:	156	Identity:	40/156 - (25%)
Similarity:	73/156 - (46%)	Gaps:	14/156 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LLLTTFLFFFYPCQFYVKSHPWVLAYQGV--ITFFVLANFTLATFM-----DPGIIPKASPDEDC 77
            |.|:||.|..|  .:..|.:|:.::...:  :.|.|.:..|:..|:     |||.:    ..:|.
Yeast   367 LFLSTFCFLIY--IWTKKLYPYSVSDYTMKNVQFLVTSFLTVVLFLRLVRSDPGCL----KTDDS 425

  Fly    78 EEELRAPLYKNAEINGITVKMKWCVTCKFYRPPRCSHCSVCNHCIETFDHHCPWVNNCIGRRNYR 142
            ...::..:.:..:: |...:..:||.....:|.|..:.......:..:||:|||:.|.:|.:|::
Yeast   426 LTSIQETIKQLIDL-GKFDRENFCVETLERKPLRSKYSFFSGALVARYDHYCPWIYNDVGLKNHK 489

  Fly   143 FFFFFLVSLSIHMLSIFSLCLVYVLK 168
            .|.||.|::..||.....|||.|..|
Yeast   490 LFVFFAVTVQYHMFLFMWLCLAYFKK 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zdhhc8	NP_001259382.1	zf-DHHC	94..219	CDD:279823	23/75 (31%)
AKR2	NP_014677.1	ANKYR	1..195	CDD:223738
		ANK repeat	54..81	CDD:293786
		ANK repeat	83..115	CDD:293786
		ANK repeat	117..148	CDD:293786
		ANK repeat	189..220	CDD:293786
		Ank_4	190..243	CDD:372654
		ANK repeat	222..247	CDD:293786
		COG5273	340..711	CDD:227598	40/156 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900