DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zdhhc8 and ZDHHC12

DIOPT Version :9

Sequence 1:	NP_001259382.1	Gene:	Zdhhc8 / 31887	FlyBaseID:	FBgn0085478	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001304944.2	Gene:	ZDHHC12 / 84885	HGNCID:	19159	Length:	322	Species:	Homo sapiens

Alignment Length:	239	Identity:	60/239 - (25%)
Similarity:	91/239 - (38%)	Gaps:	79/239 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 ITFFVLANFTL-----ATFMDPGII-PKASPDEDCEEELRAPLYKNAEINGITVKMKWCVTCKFY 107
            :||.:|...:|     .:.||||.: .:..|.|:.:||..|.:..       .:.::.|..|...
Human   103 LTFLLLVLGSLLLYLAVSLMDPGYVNVQPQPQEELKEEQTAMVPP-------AIPLRRCRYCLVL 160

  Fly   108 RPPRCSHCSVCNHCIETFDHHCPWVNNCIGRRNYRFFFFFLVSLSIHMLSIFSLCLVYVLKIMPN 172
            :|.|..||..|..|:..:||||||:.||:|.||:..|..:|           :|.||
Human   161 QPLRARHCRECRRCVRRYDHHCPWMENCVGERNHPLFVVYL-----------ALQLV-------- 206

  Fly   173 IKDTAPIVAIILMGL------------------------VTILAIPIFGLTG-----FHMVLVSR 208
                     ::|.||                        .|.|.:.:|.|..     .|:.||:.
Human   207 ---------VLLWGLYLAWSGLRFFQPWGQWLRSSGLLFATFLLLSLFSLVASLLLVSHLYLVAS 262

  Fly   209 GRTTNEQVTGKFKGGY------NPFSRGCWHNCCYTQFGPQYPS 246
            ..||.|.:: ..:..|      |||.||...|..:...|  :||
Human   263 NTTTWEFIS-SHRIAYLRQRPSNPFDRGLTRNLAHFFCG--WPS 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zdhhc8	NP_001259382.1	zf-DHHC	94..219	CDD:279823	37/153 (24%)
ZDHHC12	NP_001304944.2	DHHC	<178..272	CDD:388695	29/122 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810