DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zdhhc8 and ZDHHC18

DIOPT Version :9

Sequence 1:	NP_001259382.1	Gene:	Zdhhc8 / 31887	FlyBaseID:	FBgn0085478	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_115659.1	Gene:	ZDHHC18 / 84243	HGNCID:	20712	Length:	388	Species:	Homo sapiens

Alignment Length:	285	Identity:	108/285 - (37%)
Similarity:	159/285 - (55%)	Gaps:	43/285 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 IVLLLTTFLFFFYPCQFYVK----SHPWVLAYQGVITFFVLANFTLATFMDPGIIPKASPDEDCE 78
            :::|.||.|||.:.|.:..:    :.|.:.|   ::.|||::.....:|.||||:|:|:..|...
Human    99 LLILTTTGLFFVFDCPYLARKLTLAIPIIAA---ILFFFVMSCLLQTSFTDPGILPRATVCEAAA 160

  Fly    79 EELR-----------APLYKNAEINGITVKMKWCVTCKFYRPPRCSHCSVCNHCIETFDHHCPWV 132
            .|.:           .|..:...|||..||:|:|.|||.:||||.||||||::|:|.||||||||
Human   161 LEKQIDNTGSSTYRPPPRTREVLINGQMVKLKYCFTCKMFRPPRTSHCSVCDNCVERFDHHCPWV 225

  Fly   133 NNCIGRRNYRFFFFFLVSLSIHMLSIFSLCLVYVLKI-------MPNIKDTAPIVAIILMGLVTI 190
            .||:||||||||:.|::|||.....||: |:|..|.:       :..:|:|...|..:::...:|
Human   226 GNCVGRRNYRFFYAFILSLSFLTAFIFA-CVVTHLTLRAQGSNFLSTLKETPASVLELVICFFSI 289

  Fly   191 LAIPIFGLTGFHMVLVSRGRTTNEQVTGKF---KGG---YNPFS-RGCWHNCCYTQFGPQYPSLL 248
            .:  |.||:|||..||:...||||.:.|.:   :||   .||:| :....|||....||..|||:
Human   290 WS--ILGLSGFHTYLVASNLTTNEDIKGSWSSKRGGEASVNPYSHKSIITNCCAVLCGPLPPSLI 352

  Fly   249 NPKKYASRRSQVQNQAI--STICND 271
            :      ||..||:..:  |.|.:|
Human   353 D------RRGFVQSDTVLPSPIRSD 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zdhhc8	NP_001259382.1	zf-DHHC	94..219	CDD:279823	62/131 (47%)
ZDHHC18	NP_115659.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67
		zf-DHHC	191..314	CDD:279823	60/125 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..388		3/8 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1264614at2759
OrthoFinder	1	1.000	-	-		FOG0000285
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R405
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850