DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zdhhc8 and zdhhc8

DIOPT Version :9

Sequence 1:	NP_001259382.1	Gene:	Zdhhc8 / 31887	FlyBaseID:	FBgn0085478	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001037871.1	Gene:	zdhhc8 / 733453	XenbaseID:	XB-GENE-976023	Length:	776	Species:	Xenopus tropicalis

Alignment Length:	992	Identity:	277/992 - (27%)
Similarity:	402/992 - (40%)	Gaps:	274/992 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPKCDVK----TRYIPATFAWIVLLLTTFLFFFYPCQFYVKS-HPWVLAYQGVITFFVLANFTLA 60
            ||....|    |:|||.:.|..:|:.:|.|||.:.|.:..:. .|.:..|.|::..||||||::|
Frog     1 MPSSTGKRFKPTKYIPVSTAAALLVGSTTLFFVFTCPWLTREISPAIPVYNGLMFLFVLANFSMA 65

  Fly    61 TFMDPGIIPKASPDEDCEEELRAPLYKNAEINGITVKMKWCVTCKFYRPPRCSHCSVCNHCIETF 125
            |||||||.|:|..|||.:::.|||||||.||..|.|:||||.||.|||||||||||||::|:|.|
Frog    66 TFMDPGIFPRADEDEDKDDDFRAPLYKNVEIKRIQVRMKWCATCHFYRPPRCSHCSVCDNCVEDF 130

  Fly   126 DHHCPWVNNCIGRRNYRFFFFFLVSLSIHMLSIFSLCLVYVLKIMPNIKDTAPIVAIILMGLVTI 190
            |||||||||||||||||:||.||:|||.||:.:||..|::||..:..:.:....:.|.:|.:..:
Frog   131 DHHCPWVNNCIGRRNYRYFFLFLLSLSTHMIGVFSFGLIFVLHHLEVLGEAHTSITISVMCVAGL 195

  Fly   191 LAIPIFGLTGFHMVLVSRGRTTNEQVTGKFKGGYNPFSRGCWHNCCYTQFGPQYPS-LLNPKKYA 254
            ..||:.||||||:|||.|||||||||||||:||.|||:|||..|..:....|..|. :::|||..
Frog   196 FFIPVIGLTGFHIVLVVRGRTTNEQVTGKFRGGVNPFTRGCCGNIQHVLCSPLSPRYIVDPKKRP 260

  Fly   255 S--------RRSQVQNQAISTICNDRSGQQTGAGSGAGGNGTAAVSGGGGGVGSGGGMRGTAVQY 311
            |        |...:..:.|:...:|              ||..|........||..|:
Frog   261 SVALKPPFIRPDVLSERQITVKISD--------------NGIQANLHRSKSKGSLEGI------- 304

  Fly   312 SPRSFYDASREKRGIQVKTYMAEG--NGYNQRSGS--TTLYSKLSPGRECSDTDLEPP-PASQSQ 371
                      ..:.::::|.:.:|  |.|:...||  |:..|.|||      ..:.|| ||
Frog   305 ----------NDKSLELQTMLPKGDPNKYSDMKGSVVTSEESSLSP------KIINPPNPA---- 349

  Fly   372 DCEPTPPLQRHNSSSFYLPQVSDSGGLNGSVSTGGGGGGDSPRHMRLYHPRHSPHARPRGLDPQR 436
                ||.:.:      |.|..|.:..::                   ||......|...||....
Frog   350 ----TPAMYK------YRPPFSTNSKVH-------------------YHTATEQIAVQEGLQDNM 385

  Fly   437 GYTSDALSPDHPVGYGVGVNGSQQQQQQALAAAAAAAAVA----AQNQRSATTTATPTMQQRIKP 497
            ....|..|.|:.....:.:   .:.::.:|..:..::.:.    |.|.||.:...:...:....|
Frog   386 FLEDDCRSTDYQSEPNLDI---PEYRKNSLHKSYQSSPLQIDPFAANSRSLSLKNSGRRESEKLP 447

  Fly   498 L-------GVATPL-VMASPVRRSNPG---------TPTQPRRPDFIGLNAQAVAQQQQQQQQAA 545
            |       |..||. .:.||...||..         .|..|.        |:...|        .
Frog   448 LQLVKSEGGTITPYKSVFSPNALSNRNGSLSYDSLLNPMSPA--------AKCTTQ--------T 496

  Fly   546 AAAAAAYYEYTSGLPPQHPQAPSIQQQQQQLLLQQQRVLMQHQQQQQALQQQQQQQQQAAVHAAH 610
            ||.:..|:.     |....:...::..::|:......||                 .:||.|...
Frog   497 AAGSVGYHS-----PYMSAKMCHLRSGERQVAHGFSPVL-----------------SRAAEHQRE 539

  Fly   611 P---QHAALAQAAYGGSPQRRFLSEGELVRQG------AGGGVAGGELSYARSNNTVDNIRELAG 666
            |   ::..|:::......:|:.:.|.|.:...      |..||.....:|     ::..:..|:.
Frog   540 PSPVRYDNLSKSIMASIQERKEMEEREKLLHSHTDSVFADSGVYDTPSTY-----SLQQVSSLSE 599

  Fly   667 SPQRGVYMWKDT----SPGFTNNAGQQQQQQQQAQQVVSSGIGSSAGTLSSSGAAAGVMPHAQYM 727
            :|:.|.|..||.    :|.|::.               :..:.||..:|||:.:.|
Frog   600 NPRAGRYGSKDNLLAGAPSFSSR---------------NPVLQSSVSSLSSAVSRA--------- 640

  Fly   728 TAGGGAHPLIMTHSRLQDYTIQQQQQQQQQQAAAAAAASY----HRSNPTSPTTMPQVSGAGQSY 788
                   |...|.|...|......|..|..| |..:..||    |:: |:||:.||:...
Frog   641 -------PRTSTTSLQADLANNNIQSHQPLQ-ARVSNGSYKSPGHQA-PSSPSGMPRSPS----- 691

  Fly   789 ILRYGGGGAVGAAGSSGSLASVTASNPAT-GGGGYQPALRGGVAVFPPNPMGNQGGGNLQTQPSP 852
               |||..|            ||..|... |.|...|..|..:.|.||:       |.:..||
Frog   692 ---YGGAKA------------VTFLNTMEFGEGTSMPIQREDLQVKPPH-------GKVNGQP-- 732

  Fly   853 QIKRKQTPTRPMSFVRALEMADSMEMQSLEQQQNGGIPGSGSVGNNQQAGGGGGGHLMQSNASNS 917
                           :.|..|:.....:...|.|...|...|  |.::..|.||
Frog   733 ---------------KGLARAECRLGSTSSSQGNTVSPSRHS--NVKKVSGVGG----------- 769

  Fly   918 GTPDRASIYDMNYEISV 934
                      ..|||||
Frog   770 ----------TTYEISV 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zdhhc8	NP_001259382.1	zf-DHHC	94..219	CDD:279823	78/124 (63%)
zdhhc8	NP_001037871.1	DHHC	99..224	CDD:366691	78/124 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	180	1.000	Domainoid score	I3445
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1264614at2759
OrthoFinder	1	1.000	-	-		FOG0000285
OrthoInspector	1	1.000	-	-		otm49120
Panther	1	1.100	-	-	O	PTHR12349
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R405
SonicParanoid	1	1.000	-	-		X1910
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.140