DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zdhhc8 and Zdhhc17

DIOPT Version :9

Sequence 1:	NP_001259382.1	Gene:	Zdhhc8 / 31887	FlyBaseID:	FBgn0085478	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001034429.1	Gene:	Zdhhc17 / 366889	RGDID:	1595790	Length:	622	Species:	Rattus norvegicus

Alignment Length:	271	Identity:	74/271 - (27%)
Similarity:	112/271 - (41%)	Gaps:	79/271 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ATFAWIVLLLTTFLFFFYPCQFYVKSHPWVLAYQGVITFFVLANFTLATFMDPGIIPKASPDEDC 77
            ||..|   :..|:.|:|:....::..|...|| ..|..|:   ||..:...||||| ||:
  Rat   355 ATKFW---MYVTWFFWFWNDLSFLSIHLPFLA-NSVALFY---NFGKSWKSDPGII-KAT----- 406

  Fly    78 EEELRAPLYKNAEINGITVKMKWCVTCKFYRPPRCSHCSVCNHCIETFDHHCPWVNNCIGRRNYR 142
            ||:.:..:.:.||...:.:.: :|.||...:|.|..||.|||.||..||||||||.||:...|:|
  Rat   407 EEQKKKTIVELAETGSLDLSI-FCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVCAGNHR 470

  Fly   143 FFFFFLVSLSIHMLSIFSLC-LVY------------------VLKIMPNIKDTAPIVAIILMGLV 188
            :|..:|..|      :|.:| ::|                  ....:..|...:|.:..:.:..|
  Rat   471 YFMGYLFFL------LFMICWMIYGCVSYWGLHCETTYTKDGFWTYITQIATCSPWMFWMFLNSV 529

  Fly   189 TILAIPIFGLTGFHMVLVS------------RGRTTNEQVTGK----FK----GGYNPFSRGCWH 233
                        ||.:.|:            .|.||||::..:    ||    ...:||:.||..
  Rat   530 ------------FHFMWVAVLLMCQMYQITCLGITTNERMNARRYKHFKVTTTSIESPFNHGCVR 582

  Fly   234 N--------CC 236
            |        ||
  Rat   583 NIIDFFEFRCC 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zdhhc8	NP_001259382.1	zf-DHHC	94..219	CDD:279823	41/155 (26%)
Zdhhc17	NP_001034429.1	Necessary and sufficient for interaction with DNAJC5 and SNAP25. /evidence=ECO:0000250\|UniProtKB:Q80TN5	1..295
		Ank_4	<60..100	CDD:290365
		ANK	77..192	CDD:238125
		ANK repeat	79..110	CDD:293786
		Ank_2	84..177	CDD:289560
		ANK repeat	112..144	CDD:293786
		ANK	143..267	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_2	151..245	CDD:289560
		ANK repeat	179..211	CDD:293786
		ANK repeat	214..245	CDD:293786
		zf-DHHC	428..558	CDD:279823	41/147 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810