Protein Alignment Zdhhc8 and ZDHHC8

DIOPT Version :10

• Sequence 1: NP_001259382.1
• Gene: Zdhhc8 / 31887
• FlyBaseID: FBgn0085478
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_001171953.1
• Gene: ZDHHC8 / 29801
• HGNCID: 18474
• Length: 778
• Species: Homo sapiens
• Alignment Length: 837
• Identity: 241/837 - (28%)
• Similarity: 348/837 - (41%)
• Gaps: 235/837 - (28%)

  Fly     9 RYIPATFAWIVLLLTTFLFFFYPCQFYVKS-HPWVLAYQGVITFFVLANFTLATFMDPGIIPKAS 72
            :|||...|..:|:.::.|||.:.|.:..:: .|.|..|.|:|..||||||::|||||||:.|:|.
Human    13 KYIPVATAAALLVGSSTLFFVFTCPWLTRAVSPAVPVYNGIIFLFVLANFSMATFMDPGVFPRAD 77

  Fly    73 PDEDCEEELRAPLYKNAEINGITVKMKWCVTCKFYRPPRCSHCSVCNHCIETFDHHCPWVNNCIG 137
            .|||.|::.|||||||.::.||.|:||||.||.|||||||||||||::|:|.|||||||||||||
Human    78 EDEDKEDDFRAPLYKNVDVRGIQVRMKWCATCHFYRPPRCSHCSVCDNCVEDFDHHCPWVNNCIG 142

  Fly   138 RRNYRFFFFFLVSLSIHMLSIFSLCLVYVLKIMPNIKDTAPIVAIILMGLVTILAIPIFGLTGFH 202
            |||||:||.||:|||.||:.:.:..|||||.....:......:.:.:|.:..:..||:.||||||
Human   143 RRNYRYFFLFLLSLSAHMVGVVAFGLVYVLNHAEGLGAAHTTITMAVMCVAGLFFIPVIGLTGFH 207

  Fly   203 MVLVSRGRTTNEQVTGKFKGGYNPFSRGCW----HNCC------YTQFGPQYPSLLNPKKYASRR 257
            :|||:|||||||||||||:||.|||:|||.    |..|      |....|:.|..::.|....|.
Human   208 VVLVTRGRTTNEQVTGKFRGGVNPFTRGCCGNVEHVLCSPLAPRYVVEPPRLPLAVSLKPPFLRP 272

  Fly   258 SQVQNQAISTICNDRSGQQTGAGSGAGGNGTAAVSGGGGGVGSGGGMRGTAVQYSPRSFYDASRE 322
            ..:...|...:....:|.:.|.|...                |.|.:             |...|
Human   273 ELLDRAAPLKVKLSDNGLKAGLGRSK----------------SKGSL-------------DRLDE 308

  Fly   323 K---------RGIQVKTYMAE------GNGYN----QRSGSTT--LYS---------KL---SPG 354
            |         ..|:..|:.::      |:..:    ||:...|  :|.         |:   .||
Human   309 KPLDLGPPLPPKIEAGTFSSDLQTPRPGSAESALSVQRTSPPTPAMYKFRPAFPTGPKVPFCGPG 373

  Fly   355 RE-------------------CSDTDLEPP---PASQSQDCEPTPPLQRHNSSSFYLPQVSDSGG 397
            .:                   .|:..|:.|   |........|:|||...::.|..|..:|
Human   374 EQVPGPDSLTLGDDSIRSLDFVSEPSLDLPDYGPGGLHAAYPPSPPLSASDAFSGALRSLS---- 434

  Fly   398 LNGSVSTGGG----------GGGDSPRHMRLYHPRHSPHARPRGLDPQRGYTS--DALSPDHPVG 450
            |..|...||.          ||..:| |..::    :|||.|.    :.|..|  ..|:|..|.|
Human   435 LKASSRRGGDHVALQPLRSEGGPPTP-HRSIF----APHALPN----RNGSLSYDSLLNPGSPGG 490

  Fly   451 YGVGVNGSQQQQQQALAAAAAAAAVAAQNQRSATTTATPTMQQRIKPLGVATPLVMASPVRRS-N 514
            :                |..|..||......|          ..:.|.....|   ..|:.|| :
Human   491 H----------------ACPAHPAVGVAGYHS----------PYLHPGATGDP---PRPLPRSFS 526

  Fly   515 PGTPTQPRRPD---FIGLNAQAVAQQQQQQQQAAAAAAAAYYEYTSGLPPQHPQAPSIQQQQQQL 576
            |....:||.|.   :..|:...:|..|:::.                           ::::::|
Human   527 PVLGPRPREPSPVRYDNLSRTIMASIQERKD---------------------------REERERL 564

  Fly   577 LLQQQRVLMQHQQQQQALQQQQQQQQQAAVHAAHPQHAALAQAAYGGSPQRRFLSEGELVRQGAG 641
            |..|...|........|  ......|||:|.:..|:..||           |:.|..:||   ||
Human   565 LRSQADSLFGDSGVYDA--PSSYSLQQASVLSEGPRGPAL-----------RYGSRDDLV---AG 613

  Fly   642 GGVAGGELSYARSNNTVDNIRELAGSPQRG---------VYMWKDTSPGFTNNAGQQQQQQQQAQ 697
            .|..|     ||:.....::..|:.|..|.         .......:||...::|..:...:|
Human   614 PGFGG-----ARNPALQTSLSSLSSSVSRAPRTSSSSLQADQASSNAPGPRPSSGSHRSPARQ-- 671

  Fly   698 QVVSSGIGSSAGTLSSSGAAAGVMPHAQYMTAGGGAHPLIMTHSRLQD----YTIQQ 750
                 |:.|..||           ||:   .:..|...:...|:.|.:    .|:|:
Human   672 -----GLPSPPGT-----------PHS---PSYAGPKAVAFIHTDLPEPPPSLTVQR 709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zdhhc8	NP_001259382.1	DHHC	99..219	CDD:396215	74/119 (62%)
ZDHHC8	NP_001171953.1	DHHC	99..224	CDD:396215	77/124 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	293..352		12/87 (14%)
		PHA03247	<333..771	CDD:223021	94/488 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	509..540		9/33 (27%)