Protein Alignment Zdhhc8 and ZDHHC5

DIOPT Version :10

• Sequence 1: NP_001259382.1
• Gene: Zdhhc8 / 31887
• FlyBaseID: FBgn0085478
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_056272.2
• Gene: ZDHHC5 / 25921
• HGNCID: 18472
• Length: 715
• Species: Homo sapiens
• Alignment Length: 769
• Identity: 242/769 - (31%)
• Similarity: 335/769 - (43%)
• Gaps: 206/769 - (26%)

  Fly     8 TRYIPATFAWIVLLLTTFLFFFYPC---QFYVKSHPWVLAYQGVITFFVLANFTLATFMDPGIIP 69
            ::|:|.:.|.|.|:..|.|||.:.|   ..||.  |.|..|..::..||||||::||||||||.|
Human    12 SKYVPVSAAAIFLVGATTLFFAFTCPGLSLYVS--PAVPIYNAIMFLFVLANFSMATFMDPGIFP 74

  Fly    70 KASPDEDCEEELRAPLYKNAEINGITVKMKWCVTCKFYRPPRCSHCSVCNHCIETFDHHCPWVNN 134
            :|..|||.|::.||||||..||.||.|:||||.||:|||||||||||||::|:|.||||||||||
Human    75 RAEEDEDKEDDFRAPLYKTVEIKGIQVRMKWCATCRFYRPPRCSHCSVCDNCVEEFDHHCPWVNN 139

  Fly   135 CIGRRNYRFFFFFLVSLSIHMLSIFSLCLVYVLKIMPNIKDTAPIVAIILMGLVTILAIPIFGLT 199
            ||||||||:||.||:||:.|::.:|...|:|||..:..:......|.:.:|.:..:..||:.|||
Human   140 CIGRRNYRYFFLFLLSLTAHIMGVFGFGLLYVLYHIEELSGVRTAVTMAVMCVAGLFFIPVAGLT 204

  Fly   200 GFHMVLVSRGRTTNEQVTGKFKGGYNPFSRGCWHN----CCYTQFGPQYPSLLNPKKYAS----- 255
            |||:|||:|||||||||||||:||.|||:.||.:|    .|.:. .|:|  |..|||..:
Human   205 GFHVVLVARGRTTNEQVTGKFRGGVNPFTNGCCNNVSRVLCSSP-APRY--LGRPKKEKTIVIRP 266

  Fly   256 --RRSQVQNQAISTICNDRSGQQTGAGSGAGGNGTAAVSGGGGGVGSGGGMRGTAVQYS-----P 313
              .|.:|.:..|:....|              ||   :.|......|.|.:..|..|.:     |
Human   267 PFLRPEVSDGQITVKIMD--------------NG---IQGELRRTKSKGSLEITESQSADAEPPP 314

  Fly   314 RSFYDASREKRGIQVKTYMAEGNGYNQRSG--------STTLYSKLSPGRECSDTDLEPPPASQS 370
            ....|.||.   ..::|::  |...|:.|.        :.|:| |..||...|.|....|.:|.:
Human   315 PPKPDLSRY---TGLRTHL--GLATNEDSSLLAKDSPPTPTMY-KYRPGYSSSSTSAAMPHSSSA 373

  Fly   371 Q----DC--EPTPPLQ--RHNS------------------SSFYLPQVSDSGGLNGSVSTGGGGG 409
            :    |.  |||...:  ||.|                  .||:...:| ||..:.|:.:..|.|
Human   374 KLSRGDSLKEPTSIAESSRHPSYRSEPSLEPESFRSPTFGKSFHFDPLS-SGSRSSSLKSAQGTG 437

  Fly   410 ---------------------------GDSPRHMRLYHPRHSP-----HARPRGLDPQRGYTSDA 442
                                       ..|..:..|..|..||     .|.|.. ||..||||..
Human   438 FELGQLQSIRSEGTTSTSYKSLANQTRNGSLSYDSLLTPSDSPDFESVQAGPEP-DPPLGYTSPF 501

  Fly   443 LS-------------------PDH----PVGY---GVGVNGSQQQQQQALAAA------------ 469
            ||                   |.|    ||.|   ...:..|.|::::.|..:
Human   502 LSARLAQQREAERHPRLVPTGPTHREPSPVRYDNLSRHIVASLQEREKLLRQSPPLPGREEEPGL 566

  Fly   470 AAAAAVAAQNQRSATTTATPTMQQRIKPLGVATPLVMASPVRRSNPGTPTQPR--RPDFIGLNAQ 532
            ..:...:......|..|::.:...:..||| .|||           |.|..||  :||  ||..:
Human   567 GDSGIQSTPGSGHAPRTSSSSDDSKRSPLG-KTPL-----------GRPAVPRFGKPD--GLRGR 617

  Fly   533 AVAQQQQQQQQAAAAAAAAYYEYTSGLPPQHPQAPSI-------QQQQQQLLLQQQRVLMQHQQQ 590
            .|                       |.|...|.||.:       .|:.|..:.:.:.|.:
Human   618 GV-----------------------GSPEPGPTAPYLGRSMSYSSQKAQPGVSETEEVAL----- 654

  Fly   591 QQALQQQQQQQQQAAVHAAHPQHAALAQAAYG-GSPQRRFLSEGELVR-QGAGG 642
            |..|..:.:.|.:.....::.|..:|..|:.| |.|.....:.|.:.: .|.||
Human   655 QPLLTPKDEVQLKTTYSKSNGQPKSLGSASPGPGQPPLSSPTRGGVKKVSGVGG 708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zdhhc8	NP_001259382.1	DHHC	99..219	CDD:396215	73/119 (61%)
ZDHHC5	NP_056272.2	DHHC	99..224	CDD:396215	76/124 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	289..715		98/470 (21%)