DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zdhhc8 and Zdhhc13

DIOPT Version :9

Sequence 1:	NP_001259382.1	Gene:	Zdhhc8 / 31887	FlyBaseID:	FBgn0085478	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_082307.1	Gene:	Zdhhc13 / 243983	MGIID:	1919227	Length:	622	Species:	Mus musculus

Alignment Length:	303	Identity:	79/303 - (26%)
Similarity:	110/303 - (36%)	Gaps:	81/303 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 YIPATFA-----WIVLLLTTFLFFF-----YPCQFYVKSHPWVLAYQGVITFFVLANFTLATFMD 64
            |:|..|.     ||  .:|.|:.||     .|..|     .::.:....:.||..   |.||  |
Mouse   346 YLPTVFLLSSIFWI--FMTWFILFFPDTAGSPLYF-----AFIFSIMAFLYFFYK---TWAT--D 398

  Fly    65 PGIIPKASPDEDCEEELRAPLYKNAEINGITVKMKWCVTCKFYRPPRCSHCSVCNHCIETFDHHC 129
            || ..|||     |||.:..:...||...:..: .:|.:|...:|.|..||.|||.|:..||.||
Mouse   399 PG-FTKAS-----EEERKVNIVTLAETGSLDFR-TFCTSCLIRKPLRSLHCHVCNSCVARFDQHC 456

  Fly   130 PWVNNCIGRRNYRFFFFFLVSLSI---------------HMLSIFS------------LCLVYVL 167
            .|...|||..|:..:.|||:|||:               |..:.|.            .|..:||
Mouse   457 FWTGRCIGFGNHHHYIFFLLSLSMVCDWIIYGSFVYWSNHCATTFKEDGLWTYLNQIVACSPWVL 521

  Fly   168 KIMPNIKDTAPIVAIILMGLVTIL------AIPIFGLTGFHMVLVSRGRTTNEQVTGKFKGGYNP 226
            .|.        ::|.......|.|      .|...|||....:.:.:.....:|.....|..||.
Mouse   522 YIF--------MLAAFHFSWSTFLLINQLFQIAFLGLTSHERISLLKQSRHMKQTLSLRKTPYNL 578

  Fly   227 ---------FSRGCWH--NCCYTQFGPQYPSLLNPKKYASRRS 258
                     |..||:.  ..|...:..||..:.:|.|....||
Mouse   579 GFTQNLADFFQCGCFGLVKPCIIDWTSQYTMVFHPAKEKVLRS 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zdhhc8	NP_001259382.1	zf-DHHC	94..219	CDD:279823	39/157 (25%)
Zdhhc13	NP_082307.1	ANK 1. /evidence=ECO:0000250\|UniProtKB:Q8IUH5	43..78
		ANK	79..192	CDD:238125
		ANK repeat	81..112	CDD:293786
		ANK 2. /evidence=ECO:0000255	81..110
		Ank_2	86..179	CDD:289560
		ANK repeat	114..146	CDD:293786
		ANK 3. /evidence=ECO:0000255	115..144
		ANK repeat	148..179	CDD:293786
		ANK 4. /evidence=ECO:0000255	148..177
		ANK	176..>269	CDD:238125
		ANK repeat	181..247	CDD:293786
		ANK 5. /evidence=ECO:0000255	181..211
		Ank_5	202..257	CDD:290568
		ANK 6. /evidence=ECO:0000255	216..245
		ANK 7. /evidence=ECO:0000255	249..277
		zf-DHHC	423..556	CDD:279823	38/141 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900