Protein Alignment Zdhhc8 and ZDHHC17

DIOPT Version :10

• Sequence 1: NP_001259382.1
• Gene: Zdhhc8 / 31887
• FlyBaseID: FBgn0085478
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_056151.2
• Gene: ZDHHC17 / 23390
• HGNCID: 18412
• Length: 632
• Species: Homo sapiens
• Alignment Length: 271
• Identity: 74/271 - (27%)
• Similarity: 112/271 - (41%)
• Gaps: 79/271 - (29%)

  Fly    13 ATFAWIVLLLTTFLFFFYPCQFYVKSHPWVLAYQGVITFFVLANFTLATFMDPGIIPKASPDEDC 77
            ||..|  :.:|.|.:|:....|.....|::.  ..|..|:   ||..:...||||| ||:
Human   365 ATKFW--MYVTWFFWFWNDLNFLFIHLPFLA--NSVALFY---NFGKSWKSDPGII-KAT----- 416

  Fly    78 EEELRAPLYKNAEINGITVKMKWCVTCKFYRPPRCSHCSVCNHCIETFDHHCPWVNNCIGRRNYR 142
            ||:.:..:.:.||...:.:.: :|.||...:|.|..||.|||.||..||||||||.||:|..|:|
Human   417 EEQKKKTIVELAETGSLDLSI-FCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHR 480

  Fly   143 FFFFFLVSLSIHMLSIFSLC-LVY------------------VLKIMPNIKDTAPIVAIILMGLV 188
            :|..:|..|      :|.:| ::|                  ....:..|...:|.:..:.:..|
Human   481 YFMGYLFFL------LFMICWMIYGCISYWGLHCETTYTKDGFWTYITQIATCSPWMFWMFLNSV 539

  Fly   189 TILAIPIFGLTGFHMVLVS------------RGRTTNEQVTGK----FK----GGYNPFSRGCWH 233
                        ||.:.|:            .|.||||::..:    ||    ...:||:.||..
Human   540 ------------FHFMWVAVLLMCQMYQISCLGITTNERMNARRYKHFKVTTTSIESPFNHGCVR 592

  Fly   234 N--------CC 236
            |        ||
Human   593 NIIDFFEFRCC 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zdhhc8	NP_001259382.1	DHHC	99..219	CDD:396215	42/150 (28%)
ZDHHC17	NP_056151.2	Necessary and sufficient for interaction with DNAJC5 and SNAP25. /evidence=ECO:0000250|UniProtKB:Q80TN5	11..305
		ANKYR	52..307	CDD:440430
		ANK repeat	89..120	CDD:293786
		ANK repeat	122..154	CDD:293786
		ANK repeat	156..187	CDD:293786
		ANK repeat	189..221	CDD:293786
		ANK repeat	224..255	CDD:293786
		DHHC	438..568	CDD:396215	42/147 (29%)