DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zdhhc8 and Zdhhc5

DIOPT Version :9

Sequence 1:	NP_001259382.1	Gene:	Zdhhc8 / 31887	FlyBaseID:	FBgn0085478	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_659136.1	Gene:	Zdhhc5 / 228136	MGIID:	1923573	Length:	715	Species:	Mus musculus

Alignment Length:	768	Identity:	236/768 - (30%)
Similarity:	334/768 - (43%)	Gaps:	204/768 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TRYIPATFAWIVLLLTTFLFFFYPCQ-FYVKSHPWVLAYQGVITFFVLANFTLATFMDPGIIPKA 71
            ::|:|.:.|.|.|:..|.|||.:.|. ..:...|.|..|..::..||||||::||||||||.|:|
Mouse    12 SKYVPVSAAAIFLVGATTLFFAFTCPGLSLNVSPAVPIYNAIMFLFVLANFSMATFMDPGIFPRA 76

  Fly    72 SPDEDCEEELRAPLYKNAEINGITVKMKWCVTCKFYRPPRCSHCSVCNHCIETFDHHCPWVNNCI 136
            ..|||.|::.||||||..||.||.|:||||.||:|||||||||||||::|:|.||||||||||||
Mouse    77 EEDEDKEDDFRAPLYKTVEIKGIQVRMKWCATCRFYRPPRCSHCSVCDNCVEEFDHHCPWVNNCI 141

  Fly   137 GRRNYRFFFFFLVSLSIHMLSIFSLCLVYVLKIMPNIKDTAPIVAIILMGLVTILAIPIFGLTGF 201
            ||||||:||.||:||:.|::.:|...|:|||..:..:......|.:.:|.:..:..||:.|||||
Mouse   142 GRRNYRYFFLFLLSLTAHIMGVFGFGLLYVLYHIEELSGVRTAVTMAVMCVAGLFFIPVAGLTGF 206

  Fly   202 HMVLVSRGRTTNEQVTGKFKGGYNPFSRGCWHN----CCYTQFGPQYPSLLNPKKYAS------- 255
            |:|||:|||||||||||||:||.|||:.||.:|    .|.:. .|:|  |..|||..:
Mouse   207 HVVLVARGRTTNEQVTGKFRGGVNPFTNGCCNNVSRVLCSSP-APRY--LGRPKKEKTIVIRPPF 268

  Fly   256 RRSQVQNQAISTICNDRSGQQTGAGSGAGGNGTAAVSGGGGGVGSGGGMRGTAVQYS-----PRS 315
            .|.:|.:..|:....|              ||   :.|......|.|.:..|..|.:     |..
Mouse   269 LRPEVSDGQITVKIMD--------------NG---IQGELRRTKSKGSLEITESQSADAEPPPPP 316

  Fly   316 FYDASREKRGIQVKTYMAEGNGYNQRSG--------STTLYSKLSPGRECSDTDLEPPPASQSQ- 371
            ..|.|| ..|::....:|.    |:.|.        :.|:| |..||...|.|....|.:|.::
Mouse   317 KPDLSR-YTGLRTHLSLAT----NEDSSLLGKDSPPTPTMY-KYRPGYSSSSTSAAMPHSSSAKL 375

  Fly   372 ---DC--EPT--------------PPLQRHN------SSSFYLPQVSDSGGLNGSVSTGGGGG-- 409
               |.  |||              |.|:..:      ..||:...:| ||..:.|:.:..|.|
Mouse   376 SRGDSLKEPTSIADSSRHPSYRSEPSLEPESFRSPTFGKSFHFDPLS-SGSRSSSLKSAQGTGFE 439

  Fly   410 -------------------------GDSPRHMRLYHPRHSP-----HARPRGLDPQRGYTSDALS 444
                                     ..|..:..|..|..||     .|.|.. ||..||||..||
Mouse   440 LGQLQSIRSEGTTSTSYKSLANQTRNGSLSYDSLLTPSDSPDFESVQAGPEP-DPPLGYTSPFLS 503

  Fly   445 -------------------PDH----PVGYGVGVNGSQQQQQQALAAAAAAAAVAAQNQRSATTT 486
                               |.|    ||.|.   |.|:.             .||:..:|.....
Mouse   504 ARLAQQREAERHPRLLPTGPPHREPSPVRYD---NLSRH-------------IVASLQEREKLLR 552

  Fly   487 ATPTMQQRIKPLGVATPLVMA-------------------SPVRRSNPGTPTQPR--RPDFIGLN 530
            .:|.:..|.:..|:....:.:                   ||:.::..|.|..||  :||  ||.
Mouse   553 QSPPLAGREEEPGLGDSGIQSTPGSGHAPRTSSSSDDSKRSPLSKTPLGRPAVPRFGKPD--GLR 615

  Fly   531 AQAVAQQQQQQQQAAAAAAAAY----YEYTSGLPPQHPQAPSIQQQQQQLLLQQQRVLMQHQQQQ 591
            ::.:...:       ....|.|    ..|:|      .:|||...:.:::.|            |
Mouse   616 SRGLGSPE-------PGTTAPYLGRSISYSS------QKAPSGVSETEEVAL------------Q 655

  Fly   592 QALQQQQQQQQQAAVHAAHPQHAALAQAAYG-GSPQRRFLSEGELVR-QGAGG 642
            ..|..:.:.|.:.....::.|..::..|:.| |.|.....:.|.:.: .|.||
Mouse   656 PLLTPKDEVQLKTTYSKSNGQPKSIGSASPGPGQPPLSSPTRGGVKKVSGVGG 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zdhhc8	NP_001259382.1	zf-DHHC	94..219	CDD:279823	76/124 (61%)
Zdhhc5	NP_659136.1	zf-DHHC	99..224	CDD:279823	76/124 (61%)
Zdhhc5	NP_659136.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	289..715		94/471 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	178	1.000	Domainoid score	I3540
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000285
OrthoInspector	1	1.000	-	-		otm43947
orthoMCL	1	0.900	-	-		OOG6_104772
Panther	1	1.100	-	-	LDO	PTHR12349
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R405
SonicParanoid	1	1.000	-	-		X1910
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.890