DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zdhhc8 and dhhc-13

DIOPT Version :9

Sequence 1:	NP_001259382.1	Gene:	Zdhhc8 / 31887	FlyBaseID:	FBgn0085478	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_500889.2	Gene:	dhhc-13 / 186797	WormBaseID:	WBGene00019257	Length:	593	Species:	Caenorhabditis elegans

Alignment Length:	314	Identity:	80/314 - (25%)
Similarity:	138/314 - (43%)	Gaps:	88/314 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IPATFA-WIVLLLTTFLFF-----------FYPCQFYV--KSHPWVLAYQGVITFFVLANFTLAT 61
            :|.|:. |:.:.....|.|           .:.|..:|  .|..|:|         :|.|
Worm   331 LPVTYIFWMGIAEFALLIFNSNGLVHWSVLIFVCSIWVISASFYWIL---------ILTN----- 381

  Fly    62 FMDPGIIPKA-SPDEDCEEELRAPLYKNAEINGITVKMKWCVTCKFYRPPRCSHCSVCNHCIETF 125
               ||::|:: :|.:|..::|     :..:|:      ::|.||...:.....|||.|:.|::.|
Worm   382 ---PGVLPRSTTPFKDFIKDL-----EEKQID------RYCFTCWIPKTSSSHHCSQCDKCVDGF 432

  Fly   126 DHHCPWVNNCIGRRNYRFFFFFLVSLSIHMLSIF-SLCLVYVLKIMPN-------IKDTAPIVAI 182
            ||||||::.|:.|:|.|.|.||  .|:|.|..:| .|.|:|::....|       :.|..
Worm   433 DHHCPWIHKCVYRKNLRAFVFF--CLTIFMFHVFYVLLLLYMIGASMNASGFEQTLNDHG----- 490

  Fly   183 ILMGLVTILAIP-IFG---LTGFHMVLVSRGRTTNEQVTGKFKGGYNPFSRGCWHNCCYTQFGPQ 243
             ||.:..||||| :||   :|......:||..:|.| :..|.:...|...:        |...|:
Worm   491 -LMVISLILAIPHVFGAGAITCTQFSQISRHVSTIE-IIRKQRLQRNSSEK--------TITSPE 545

  Fly   244 YPSLLNPKKY-ASRRSQVQNQAISTICN----DR--SGQQTGAGSGAGGNGTAA 290
            :    ||.:| .|.:::::|     :||    |:  .|::...|.|:....|::
Worm   546 H----NPWEYKQSVKTRIRN-----VCNLLAFDKFGDGEEIDEGHGSSSFETSS 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zdhhc8	NP_001259382.1	zf-DHHC	94..219	CDD:279823	45/136 (33%)
dhhc-13	NP_500889.2	ANK	42..155	CDD:238125
		Ank_2	42..132	CDD:289560
		ANK repeat	67..98	CDD:293786
		ANK repeat	101..132	CDD:293786
		Ank_5	121..176	CDD:290568
		ANK	130..>240	CDD:238125
		Ank_5	198..243	CDD:290568
		ANK repeat	206..234	CDD:293786
		zf-DHHC	405..530	CDD:279823	45/139 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810