DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zdhhc8 and dhhc-14

DIOPT Version :9

Sequence 1:	NP_001259382.1	Gene:	Zdhhc8 / 31887	FlyBaseID:	FBgn0085478	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001024514.2	Gene:	dhhc-14 / 181109	WormBaseID:	WBGene00044071	Length:	565	Species:	Caenorhabditis elegans

Alignment Length:	282	Identity:	74/282 - (26%)
Similarity:	124/282 - (43%)	Gaps:	73/282 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RYIP---ATFAWIV--LLLTTFLFFFYP--------------------------CQFYVKSHPWV 42
            :|:|   |||:.::  :.|...:.|.|.                          ..:||   ||.
Worm   288 KYLPLIIATFSTLISCIFLMVLIRFDYHDPTYKLLPYGVTIAEAILMVLSWSAYAHWYV---PWW 349

  Fly    43 LAYQGVITFFVLANFTLATF--MDPGIIPKASPDEDCEEELRAPLYKNAEINGITVKMKWCVTCK 105
            .....|::...|| |||...  :|||::..|   ::|.:     |:.|....||..:.|:|.||.
Worm   350 AQMLFVLSVLALA-FTLFRIGTLDPGVVRAA---KNCHQ-----LFVNEAEAGIQHQQKYCFTCF 405

  Fly   106 FYRPPRCSHCSVCNHCIETFDHHCPWVNNCIGRRNYRFFFFFLVSLSIHMLSIFSLCLVY--VLK 168
            ..:.....||:||..|:..|||||||:|:|:.|||.|.|..|::|:|:.. :|:.:...:  :|:
Worm   406 IRKMDHTKHCAVCGFCVNNFDHHCPWLNSCVTRRNMREFIMFVISVSVSS-AIYCMATSHYALLQ 469

  Fly   169 IMPN------IKDTAPIVAIILMGLVTILAIPIFGLTGFHMVLVSRGRTTNEQVTGKFKG----- 222
            |..:      ..|...::.|||..:..::...:|.:   .|..:|:|.|||:::..:..|
Worm   470 IEDHGLEEFLETDAFLMITIILSAMHALMLAVLFCV---QMNQISQGVTTNDRIKARRAGHAHSH 531

  Fly   223 ----GYN------PFSRGCWHN 234
                .||      ..|:.| ||
Worm   532 SGSTDYNVIHHKPSISKRC-HN 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zdhhc8	NP_001259382.1	zf-DHHC	94..219	CDD:279823	41/132 (31%)
dhhc-14	NP_001024514.2	ANK	19..143	CDD:238125
		Ank_2	30..120	CDD:289560
		ANK repeat	55..87	CDD:293786
		ANK repeat	89..120	CDD:293786
		Ank_2	94..222	CDD:289560
		ANK	117..244	CDD:238125
		ANK repeat	190..222	CDD:293786
		PulO	<261..>367	CDD:224900	18/82 (22%)
		zf-DHHC	394..521	CDD:279823	41/130 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910