DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zdhhc8 and dhhc-8

DIOPT Version :9

Sequence 1:	NP_001259382.1	Gene:	Zdhhc8 / 31887	FlyBaseID:	FBgn0085478	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001370072.1	Gene:	dhhc-8 / 176731	WormBaseID:	WBGene00012718	Length:	471	Species:	Caenorhabditis elegans

Alignment Length:	538	Identity:	181/538 - (33%)
Similarity:	255/538 - (47%)	Gaps:	119/538 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 CDVKTRYIPATFAWIVLLLTTFLFFFYPCQFYVKSHPW---------VLAYQGVITFFVLANFTL 59
            |...:..:||..||.:::..:..||     :::....|         ::|...|:...|.:|..:
Worm     2 CKRISALLPAAIAWALIIGCSVSFF-----WFIAPQIWNQWHTPGLILIAIDVVLFLMVSSNLLM 61

  Fly    60 ATFMDPGIIPKASPDEDCE--EELRAPLYKNAEINGITVKMKWCVTCKFYRPPRCSHCSVCNHCI 122
            |..:||.:.|.|...|:..  ::||||||||.:||||||:||||||||||||||.|||||||.||
Worm    62 AMLLDPAVHPYAIGSEEPTQVDDLRAPLYKNVDINGITVRMKWCVTCKFYRPPRSSHCSVCNRCI 126

  Fly   123 ETFDHHCPWVNNCIGRRNYRFFFFFLVSLSIHMLSIFSLCLVYV-----LKIMPNIKDTAPIVAI 182
            ||||||||||:||:|:||||:|||||.||||||:.:|.||..||     .....:|.....:.||
Worm   127 ETFDHHCPWVHNCVGKRNYRYFFFFLCSLSIHMMYVFFLCFAYVWSGSDTNARDHILSPPYLCAI 191

  Fly   183 ILMGLVTILAIPIFGLTGFHMVLVSRGRTTNEQVTGKFKGGYNPFSRGCWHNC----CYTQFGPQ 243
            :|:.|..:|.:|:.|||.||:|||:|||||||||||||..|||||:.|||.||    |::|. |.
Worm   192 VLLALCAVLCVPVIGLTVFHLVLVARGRTTNEQVTGKFTSGYNPFTIGCWGNCKKTLCHSQL-PT 255

  Fly   244 YPSLLNPKKYASRRSQVQNQAISTICNDRSGQQTGAGSGAGGNGTAAVSGGGGGVGSGGGMRGTA 308
            :.|  :..::..:|.:.|.:..:.|......|...|.....                     .|:
Worm   256 FKS--HVMEFRKQRKEEQARLANRINGPVEEQNAHADDERD---------------------ETS 297

  Fly   309 VQYSPRSFYDASREKRGIQVKTYMAEGNGYNQRSGSTTLYSKLSPGRECSDTDLEPPPASQSQDC 373
            |.|.|    |..|....:.......:.|...::..:||..|:.......::        ||||
Worm   298 VLYVP----DQKRADGKMVAVVEFNKNNSVLRQQNTTTTTSRSESQNRITE--------SQSQ-- 348

  Fly   374 EPTPPLQRHNSSSFYLPQVSDSGGLNGS-VSTGGGGGGDSP--RHMRLYH-------PRHSPHAR 428
                             .:|.|.|.:.| ::.||||||...  ....|:.       ||.:...|
Worm   349 -----------------SMSMSSGCDESRITVGGGGGGAEADGSTCNLFEMERGGGTPRPNSSLR 396

  Fly   429 PRGLDPQRGYTSDALSPDHPVGYGVGVNGSQQQQQQALAAA--AAAAAVAAQN-------QRSAT 484
            ...:..:   |.|..|..|            |..::||..|  ..|:.|..::       :|:.:
Worm   397 SARVHDE---TVDTPSATH------------QSYEEALEEALHGPASPVTTEDSINSKSGRRTPS 446

  Fly   485 TTAT-PT----MQQRIKP 497
            .||| ||    :.|.:.|
Worm   447 RTATSPTSGSAILQHLPP 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zdhhc8	NP_001259382.1	zf-DHHC	94..219	CDD:279823	84/129 (65%)
dhhc-8	NP_001370072.1	DHHC	98..228	CDD:396215	84/129 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	185	1.000	Domainoid score	I2016
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	298	1.000	Inparanoid score	I1645
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1264614at2759
OrthoFinder	1	1.000	-	-		FOG0000285
OrthoInspector	1	1.000	-	-		oto19545
orthoMCL	1	0.900	-	-		OOG6_104772
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R405
SonicParanoid	1	1.000	-	-		X1910
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.760