DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31643 and XPNPEP3

DIOPT Version :9

Sequence 1:	NP_001285652.1	Gene:	CG31643 / 318867	FlyBaseID:	FBgn0051643	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_071381.1	Gene:	XPNPEP3 / 63929	HGNCID:	28052	Length:	507	Species:	Homo sapiens

Alignment Length:	458	Identity:	88/458 - (19%)
Similarity:	149/458 - (32%)	Gaps:	133/458 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   415 LESCPEKHLHLRFLRHCQRYMNFNNNLGGTYRHL-----------ELERKLSR-MCMNAIEHDIA 467
            |:..||:.:..|:|.....:         |:.||           ::|..|.| ..|:.|:.:..
Human    33 LQPVPERRIPNRYLGQPSPF---------THPHLLRPGEVTPGLSQVEYALRRHKLMSLIQKEAQ 88

  Fly   468 GRLPAKFARLASFVLAYGQTPLAWKKFPNFLLSKMLAMAPQLGIQD-CFLLSRGMQIASELRFRQ 531
            |:            ....||.:.... |.:.:|..:   |....|| .||...|.|....:...|
Human    89 GQ------------SGTDQTVVVLSN-PTYYMSNDI---PYTFHQDNNFLYLCGFQEPDSILVLQ 137

  Fly   532 HLPALAGMQLSTMDSILIGCAERHLRDAEKDPLNASE-------------LSMIVRTLSHRKKLK 583
            .||   |.||.:..:||........|:....|.:.::             |......|...|...
Human   138 SLP---GKQLPSHKAILFVPRRDPSRELWDGPRSGTDGAIALTGVDEAYTLEEFQHLLPKMKAET 199

  Fly   584 NTVVYNQALAQYKNLHCNDLNSRVVRDMAYNFNASNFFVPELLESMFAYISEQHDHVSGDTVEKV 648
            |.|.|:.....:..||                  |::..| |.|:.    ::..:.|.|  |:::
Human   200 NMVWYDWMRPSHAQLH------------------SDYMQP-LTEAK----AKSKNKVRG--VQQL 239

  Fly   649 LTCSYNLGYMPASVEALNHASEVLLRDFDQMSGLSVVQACLALCFYKSIPEQLINQVFCVKFIQR 713
            :. ...|...||.:|.:            |::|....||.:...|....|   :.:.|   ...:
Human   240 IQ-RLRLIKSPAEIERM------------QIAGKLTSQAFIETMFTSKAP---VEEAF---LYAK 285

  Fly   714 IEDEIQVCYSKA----TYPERVLNLVMQLNRTVCLDFPEANVPWFQQNYIEAQISKKS---LIPS 771
            .|.|   |.::.    .||.    :|...||:..|.:.:.|           |:.|..   |:..
Human   286 FEFE---CRARGADILAYPP----VVAGGNRSNTLHYVKNN-----------QLIKDGEMVLLDG 332

  Fly   772 --ESTTEVKQLLHQLLQNDKHFRCNHTTPYGYQIDFVIHFDRDKNPIPAPPVEATMLDRITKVAI 834
              ||:..|..:......|.:     .|.|.....:.|:...||...:..|   .|.|:.|..:.:
Human   333 GCESSCYVSDITRTWPVNGR-----FTAPQAELYEAVLEIQRDCLALCFP---GTSLENIYSMML 389

  Fly   835 LLL 837
            .|:
Human   390 TLI 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31643	NP_001285652.1	FAST_1	647..713	CDD:284217	11/65 (17%)
		FAST_2	736..816	CDD:285557	16/84 (19%)
		RAP	834..894	CDD:214932	1/4 (25%)
XPNPEP3	NP_071381.1	Interaction with TNFRSF1B. /evidence=ECO:0000269\|PubMed:25609706	54..79		5/24 (21%)
		PRK10879	67..506	CDD:182804	80/415 (19%)
		AMP_N	72..205	CDD:282980	31/151 (21%)
		Prolidase	252..490	CDD:238520	35/185 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D352329at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010