DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31643 and Fastkd1

DIOPT Version :9

Sequence 1:	NP_001285652.1	Gene:	CG31643 / 318867	FlyBaseID:	FBgn0051643	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_796218.2	Gene:	Fastkd1 / 320720	MGIID:	2444596	Length:	829	Species:	Mus musculus

Alignment Length:	891	Identity:	199/891 - (22%)
Similarity:	391/891 - (43%)	Gaps:	156/891 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 PREQDALLTRLEEAKTGNQILDVLESCDG-LQSSHVVMGISLLWNIYHDAEQASKDAITDRV--- 129
            |...::|:|::::.....|:.|::|:... |....|....::||..........|:  .|.|
Mouse    19 PFSCESLITQMQKCTNEEQVFDLIETNTATLSEQQVGCAFNVLWQFQKQKTVLEKN--VDHVRNH 81

  Fly   130 -----LLNVLPKLAPYVHQLEIDDLSRCYLY-LRKMHIPNSEAVVEAVLTRSLQLIESQVDDEVI 188
                 |.::.....|.:....:.|:    || :::..:.:...::||::|.:.:.:| :.|..|
Mouse    82 PQFLTLCSITTNHIPAMSDATLVDV----LYSIKQFAVESHHPLIEALVTEAWKRLE-RFDTNV- 140

  Fly   189 PLTSLSRLSVGINLERDFFTPLVCRNFIPHLEHHIN-WCRSAEQVRLLSTCLFQLHFLIDEELFT 252
                ||..|..:..:..:|:||:.:     :...:| ...:.:.:|.||..:..:..||......
Mouse   141 ----LSIFSTCLADQHLYFSPLMGK-----IADIVNRRLETIQDLRALSVLMVSISSLISPCFQE 196

  Fly   253 RFKLRLTEMMQSGVLSSETPKALLKVIHMLNIPVWSQTHTQLIREVMLVLRPCIHQMESADLKSI 317
            |..:| ||::...|.||:...|...::.:.|:   ..:|..|:.....|.   |..|...||:||
Mouse   197 RLVIR-TELLFDTVNSSKVNIARRILLFLRNV---KYSHYPLLERCNQVF---IRNMSHLDLESI 254

  Fly   318 CRTFLHHQ----EPAALIEPLKKALEKLLQEEGTADA---LFCAVPFATPLQRDQYLHQFKE--L 373
            .:....:|    .....:|..:..|.::.......::   ||.|:   .|:.|.:...|.|.  |
Mouse   255 SKILNLYQFLQFHSFEFVEAARGRLAEMTLPSDHPESFVRLFAAL---GPVARPEIKKQLKSTIL 316

  Fly   374 LYSEEAWQQPNASGHLFSVLRALKVSDIEFCNTYWSGVVKELESCPEKHL----HLRFLRHCQ-- 432
            |.|||.     :|.....||.|::  |:|..|::   ::|::.|...|||    .:..|:..|
Mouse   317 LLSEEL-----SSQQALIVLGAME--DMESRNSH---LLKKIVSVLYKHLDNYKSIELLKIIQAL 371

  Fly   433 RYMNFNNNLGGTYRHLELERKLSRMCMNAIEHDIAGRLPAKFARLASFVLAYGQTPLAWKKFPNF 497
            .:::|.:.        ||..||..:.::.:|   |..:|::.:.|.|        .|:....|:.
Mouse   372 TFLHFQSK--------ELFMKLRELLLSRLE---ASVIPSEISVLVS--------ALSMLPHPHL 417

  Fly   498 ---LLSKMLAMAPQLGIQD----CFLLSRGMQIASELRFRQHLPALAGMQLSTMDSI-LIGCAER 554
               .:|::.|:.||...::    ...|.|.:|  |:|   ..|.:..|.||..:..: .:|   |
Mouse   418 SETAVSRIEAVLPQCDFRELNDLVVYLMRWIQ--SDL---VCLASTTGKQLDLLQKLDQLG---R 474

  Fly   555 H-LRDAEKDPLNASELSMIVRTLSHRKKLKNTVVYNQALAQYKNLHCNDLNSRVVRDMAYNFNAS 618
            | |:.:....|...||..:.....|...::.::.   ||.::    .::::...:..:|...:.:
Mouse   475 HRLQQSTNLDLLWEELKSLKGEWLHESLVEESIA---ALLRF----MDEIDYSNIAKVASFLSRT 532

  Fly   619 NFFVPELLESMFAYISEQHDHVSGDTVEKVLTCSYNLGYMPASVEALNHASEVLLRDFDQMSGLS 683
            |:....||:.:.:...:|        |||:...|.....:|.|:  ||:...    ..|:..| :
Mouse   533 NYLNTLLLDRIASVAIQQ--------VEKIHPFSVLAIILPFSI--LNYDPP----QKDEFFG-A 582

  Fly   684 VVQAC----------------LALCFYKSIPEQLINQVFCVKFIQRIEDEIQVCYSKATYPERVL 732
            .||.|                .:|...:..||.|:.::|.::|:.|::.::::..|..:  .|:.
Mouse   583 CVQCCNSYLGTLDPGTLVFLGFSLAVLEYFPEDLLKKMFNIEFLARLDSQLEILPSSLS--ARIQ 645

  Fly   733 NLVMQLNRTVCLDFPEANVPWFQQNYIEAQISKKSLIPSESTTEVKQLLHQLLQNDKHFRCNHTT 797
            ..:|:|||.|||:.||..||||...:.:.|.:|.:.:.:.:..::.::|.::|...:..:.:..:
Mouse   646 FRLMELNRAVCLECPELQVPWFHDRFCQRQFNKDTGVMNGAQQQIYKMLAEVLGGHQCVKPSALS 710

  Fly   798 PYGYQIDFVIHFDRDKNPIP------AP----------PVEATMLDRITKVAILLLKLDSFCEND 846
            ||.:.:.|....|:.|.|:|      ||          .||..:.....::||.||.:.:||.|
Mouse   711 PYYHTVGFECILDKRKKPLPYESHSIAPRKSLGMHWDSRVEPRLPPEAERIAIELLDVRAFCSN- 774

  Fly   847 LTALRGPESLKMRHLEMMGYKVMQINEHDWNSKYMASSTAKANYLK 892
            :..|:|..::|.||||::||:|:||...:|||..|::..|:.:||:
Mouse   775 IPHLKGKSAMKKRHLEILGYRVIQIPYFEWNSMAMSTKDARMDYLR 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31643	NP_001285652.1	FAST_1	647..713	CDD:284217	17/81 (21%)
		FAST_2	736..816	CDD:285557	22/79 (28%)
		RAP	834..894	CDD:214932	25/59 (42%)
Fastkd1	NP_796218.2	FAST_1	560..628	CDD:284217	15/74 (20%)
		FAST_2	648..729	CDD:285557	22/80 (28%)
		RAP	763..821	CDD:214932	25/59 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837981
Domainoid	1	1.000	57	1.000	Domainoid score	I10932
eggNOG	1	0.900	-	-		E1_28HV5
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	129	1.000	Inparanoid score	I4626
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007973
OrthoInspector	1	1.000	-	-		oto93224
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21228
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5917
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.850