DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31643 and Fastkd1

DIOPT Version :9

Sequence 1:	NP_001285652.1	Gene:	CG31643 / 318867	FlyBaseID:	FBgn0051643	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_001178667.1	Gene:	Fastkd1 / 311112	RGDID:	1563531	Length:	832	Species:	Rattus norvegicus

Alignment Length:	902	Identity:	195/902 - (21%)
Similarity:	384/902 - (42%)	Gaps:	175/902 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 PREQDALLTRLEEAKTGNQILDVLESCDG-LQSSHVVMGISLLWNIYHDAEQASKDAITDRV--- 129
            |...::|:.:::......|:.|::|.... |....|....::||..........|:  .:||
  Rat    19 PFSCESLIVQMQNCADEEQVFDLIERNKATLSEQQVGCAFNVLWQFQKQKTILEKN--VERVRNH 81

  Fly   130 -----LLNVLPKLAPYVHQLEIDDLSRCYLY-LRKMHIPNSEAVVEAVLTRSLQLIESQVDDEVI 188
                 |.:|.....|.:..:.:.|:    || :::..:.:...::||::|...:.:|.      .
  Rat    82 PQFLSLCSVTTDHIPAMSDVTLVDV----LYSIKQFAVESHHPLIEALVTEGWRRLER------F 136

  Fly   189 PLTSLSRLSVGINLERDFFTPLVCRNFIPHLEHHINWCRSAEQV---RLLSTCLFQLHFLI---- 246
            .:..||..|..:..:..:|:||:.:     :...:|  |..|.:   |.||..:..:..||
  Rat   137 DINVLSIFSTCLADQHLYFSPLMGK-----IADIVN--RKLEAIQDLRALSVLMVSISSLISPCF 194

  Fly   247 DEELFTRFKLRLTEMMQSGVLSSETPKALLKVIHMLNIPVWSQTHTQLIREVMLVLRPCIHQMES 311
            .|.|.||     .|::...|.||:...|...::.:.|:   ..:|..|:.....|.   |..:..
  Rat   195 QERLLTR-----AELLFDTVDSSKVNIARRILLFLRNV---KHSHYPLLERCNQVF---IRNVSH 248

  Fly   312 ADLKSICRTFLHHQ----EPAALIEPLKKALEKLLQEEGTADA---LFCAVPFATPLQRDQYLHQ 369
            .||:||.|....:|    .....||..:..|.:|.......::   ||.|:   .|:.|.:...|
  Rat   249 LDLESISRILSLYQSLQFHSFEFIEVARGRLAELSLPSDHPESFVRLFAAL---GPVARPEIRKQ 310

  Fly   370 FKE--LLYSEEAWQQPNASGHLFSVLRALKVSDIEFCNTYWSGVVKELESCPEKHL----HLRFL 428
            .|.  ||.|||.     :|....:||.|::  |:|..:::   ::|::.|...:||    .:..|
  Rat   311 LKSTILLLSEEL-----SSQQALTVLGAME--DMESRDSH---LIKKIVSVLYRHLDNCKSVELL 365

  Fly   429 RHCQ--RYMNFNNNLGGTYRHLELERKLSRMCMNAIEHDIAGRLPAKFARLASFVLAYGQTPLAW 491
            :..|  .:::|.:.        ||..||..:.::.:|..:.   |::.:.|.|        .|:.
  Rat   366 KIIQALTFLHFQSK--------ELFMKLREVLLSRLEASVT---PSEVSVLVS--------ALSM 411

  Fly   492 KKFPNF---LLSKMLAMAPQLGIQD------CFLLSRGMQIASELRFRQHL--PALAGMQLSTMD 545
            ..:|:.   .||:...:.||...::      |  |.|.:|       ..||  .:.||.||..:.
  Rat   412 LPYPHLNETALSRTETVLPQCDFRELSDLVVC--LMRWIQ-------NDHLCSASTAGKQLDLLQ 467

  Fly   546 SILIGCAERHLRDAEKDPLNASELSMIVRTLSHRKKLKNTVVYNQALAQYKNLHCNDLNSRVVRD 610
            . |.....|.|:.:....|...||..:.....|...::.::.   ||.::    .::::...|..
  Rat   468 K-LDHWGHRRLQQSTSLDLLWEELKSVKGEWLHESLVEESIT---ALQRF----MDEIDHSNVAK 524

  Fly   611 MAYNFNASNFFVPELLESMFAYISEQHDHVSGDTVEKVLTCSYNLGYMPASVEALNHASEVLLRD 675
            :|...:.:|:....||:.:.:.:.||        ::|:...|.....:|.|:  ||:...    .
  Rat   525 IASFLSKTNYLSTPLLDRIASVVVEQ--------IKKIHPFSVLAIILPFSI--LNYDPP----Q 575

  Fly   676 FDQMSGLSVVQAC----------------LALCFYKSIPEQLINQVFCVKFIQRIEDEIQVCYSK 724
            .|:..| :.||.|                .::...:..||.|:.::|.::|:.|::.::::..|.
  Rat   576 KDEFFG-ACVQCCNSYLGTLDPGTLVFLGFSMATLEYFPEDLLKKMFNIEFLARLDSQLEILPSS 639

  Fly   725 ATYPERVLNLVMQLNRTVCLDFPEANVPWFQQNYIEAQISKKSLIPSESTTEVKQLLHQLLQNDK 789
            .:  .|:...:|:|||.|||:.||..||||...:.:.|.:|.:.:.:.:..::.::|.::|...:
  Rat   640 LS--ARIQFRLMELNRAVCLECPELQVPWFHDRFCQRQFNKDTGVMNGAQQQIYKMLAEVLGGHR 702

  Fly   790 HFRCNHTTPYGYQIDFVIHFDRDKNPIP----------APPV---------EATMLDRITKVAIL 835
            :.:.:..:||.:.:||....|:.|.|:|          :|.|         |..:.....::||.
  Rat   703 YVKPSTLSPYYHTVDFECILDKRKKPLPYESHSVTPGKSPGVHGDSNTSRAEPRLPPEAERIAIE 767

  Fly   836 LLKLDSFCENDLTALRGPESLKMRHLEMMGYKVMQINEHDWNSKYMASSTAKANYLK 892
            .|.:.:||.| :..|:|..::|.||||::||:|:|:...:|||..|::...:.:||:
  Rat   768 FLDVRAFCSN-ILHLKGKSAMKKRHLEILGYRVIQVPYFEWNSMAMSTKDTRMDYLR 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31643	NP_001285652.1	FAST_1	647..713	CDD:284217	16/81 (20%)
		FAST_2	736..816	CDD:285557	23/79 (29%)
		RAP	834..894	CDD:214932	22/59 (37%)
Fastkd1	NP_001178667.1	FAST_1	560..628	CDD:284217	14/74 (19%)
		FAST_2	648..729	CDD:285557	23/80 (29%)
		RAP	766..824	CDD:214932	22/59 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341757
Domainoid	1	1.000	62	1.000	Domainoid score	I10160
eggNOG	1	0.900	-	-		E1_28HV5
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	128	1.000	Inparanoid score	I4565
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D352329at2759
OrthoFinder	1	1.000	-	-		FOG0007973
OrthoInspector	1	1.000	-	-		oto96771
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21228
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5917
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.860