DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dtr and LRRCC1

DIOPT Version :9

Sequence 1:	NP_724335.2	Gene:	dtr / 318856	FlyBaseID:	FBgn0023090	Length:	1483	Species:	Drosophila melanogaster
Sequence 2:	XP_016869409.1	Gene:	LRRCC1 / 85444	HGNCID:	29373	Length:	1046	Species:	Homo sapiens

Alignment Length:	1228	Identity:	258/1228 - (21%)
Similarity:	457/1228 - (37%)	Gaps:	348/1228 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 DVLYLHYQGFQCIESLEEYTELKCLWLECNAISEIQGLEKLSKLKCLFLQNNLITKIENLDPCRE 101
            ||.::. :|.|.|..|...:.|..:.|.||.||:|:.::.:..|:.|.|.:|.|::||.|:...:
Human    25 DVCFMD-KGLQSISELSLDSTLHAVNLHCNNISKIEAIDHIWNLQHLDLSSNQISRIEGLNTLTK 88

  Fly   102 LDTLNLSSNHIRKIQNIGTNVLPVLNTLTISSNYLKDSESLSDLIQCK-TLSVLDLSNNRIDDIL 165
            |.|||||.|.|.|::  |...|..|..|.:|.|::.|...|..|...| .|..:||.:||||.
Human    89 LCTLNLSCNLITKVE--GLEELINLTRLNVSYNHIDDLSGLIPLHGIKHKLRYIDLHSNRIDS-- 149

  Fly   166 IVKIFEQMLNLKV---LVLQ----GNPVV-------------SRLPQYRKTLILACKELTYLDSR 210
            |..:.:.|:.|..   |:|:    .|||.             |.|..||..::....:|..||.:
Human   150 IHHLLQCMVGLHFLTNLILEKDGDDNPVCRLPGTSLNTVTLPSELRGYRAVILQTLPQLRILDCK 214

  Fly   211 PVFPRDRACAEAWKRDGYEGERKENNRWNRAERRKTRESINCTI---------------RMRNSH 260
            .:|                ||.......|.::.:.....::..:               ||....
Human   215 NIF----------------GEPVNLTEINSSQLQCLEGLLDNLVSSDSPLNISEDEIIDRMPVIT 263

  Fly   261 RPPDQQDPLLRSSDSEDD--------TCAETARKKVALENGCVDDLWEEVSGE-------QPISE 310
            .|.|:..||.:.:.:..|        .|..:..:|...||    ||..|:..:       |.::|
Human   264 APIDELVPLEQFASTPSDAVLTSFMSVCQSSEPEKNNHEN----DLQNEIKLQKLDDQILQLLNE 324

  Fly   311 DGTNSSSSLE-------DNDGTSSQDDLIAEKLSNR----RTLEGRPTVLYETE-VSNVKSANND 363
            ...:..:.||       |.|.||..|      ..||    |.:..|..:.|:.: :..:|..|.:
Human   325 TSNSIDNVLEKDPRPKRDTDITSESD------YGNRKECNRKVPRRSKIPYDAKTIQTIKHHNKN 383

  Fly   364 INIFEEGVGKASQIIIEDKPVTKIKLINEPSCMNDKSAMNCTSMGPVVKENDFDEDAEIKNVDDM 428
            .|.|.....|.....:::..|:             .|..||    |:::|:: ....||..||
Human   384 YNSFVSCNRKMKPPYLKELYVS-------------SSLANC----PMLQESE-KPKTEIIKVD-- 428

  Fly   429 VPCQNLIKSNEDINSEFGFSSKLKQDFDQTCTALRNDAECKEFDEELTIKESESKPFNEMYDIFA 493
                   :|:.:.|:......:|.|:.::...|.:.:.:..::.:||      .|..||..||.:
Human   429 -------QSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDEL------HKHANEKEDIHS 480

  Fly   494 ---AEDDKLNETLDLNLNETTCPHHVHDNFFSEQNKMPSFYEEDIMINLLPKTKEKTLLE----K 551
               ...|:|.|.:                 |.|:|   |..:.::|::.|....:|..:|    |
Human   481 LALLTTDRLKEII-----------------FRERN---SKGQLEVMVHKLQNEIKKLTVELMKAK 525

  Fly   552 DSIIENEKCAHDLDEMGRQMEEDLAELRQSTQNLIGISIDETARTDSETDEEDLIAQQDPYSPLL 616
            |                 |.|:.|..||...:.|                 |.:..|
Human   526 D-----------------QQEDHLKHLRTLEKTL-----------------EKMERQ-------- 548

  Fly   617 KQQFKDRRMKIMLTEETKAQEESLSDRNI-----ALSNESDQDDKQDQLFAKILDDATENIPKRI 676
            |:|.:..:::::...|.||   |.:||.|     :|..|.:|..:..||.|....:..:.:..|.
Human   549 KRQQQAAQIRLIQEVELKA---SAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETRE 610

  Fly   677 FGTGC---DALSSVWPQEECLLQLTLPENKES--------PAQEDTFKKSIT-NSTSFEKANEIC 729
            |.|..   |||:....:||...:..:.|.:|.        ...|:.|:.::| .:..|:...:..
Human   611 FFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGF 675

  Fly   730 VRMDQKMAEEEEAL----------GKLLHDLEGEINNVYDINTKV----KYEENTSTNESDAVSI 780
            ..:..::|:.:.||          ..|:.||...:.   :..||:    |.::.|:.|..:.::.
Human   676 ENVATELAKSKHALIWAQRKENESSSLIKDLTCMVK---EQKTKLAEVSKLKQETAANLQNQINT 737

  Fly   781 CTSLLDDIIVGLTFDEVLCHEK---------PKSFEFGLIESDEEFSYSFEPKLEKLVPPALEDP 836
            ...|::|........|:|.|||         .:|..|||....:.:.:....:...|.....:..
Human   738 LEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLE 802

  Fly   837 ARGKSL---RECLDTFSDFVSSMADPKLPVMLGRNPTSGVEKIRAAQELLKTKN---------LS 889
            |:.:||   .|||...::..|.....|..::     ....|.||..::.|:.|:         ::
Human   803 AQIESLSRENECLRKTNESDSDALRIKCKII-----DDQTETIRKLKDCLQEKDEHIKRLQEKIT 862

  Fly   890 DLYKDTAESL---NSQVAKEIEKRKRRVAASATRCFNQR-DKYDDTLELVENRLMIVKK------ 944
            ::.|.|.|.|   :||:.:.:||.:|.         |:| :|....|:..|..|..::|
Human   863 EIEKCTQEQLDEKSSQLDEVLEKLERH---------NERKEKLKQQLKGKEVELEEIRKAYSTLN 918

  Fly   945 ----DSGDLEELPPPPPLISDTESEDDNPTEDNYTPGNEVHRHGTKTQDSKEHL--MSNLLNQNQ 1003
                |.|:         |:...|                     |:.::.||..  ....|...:
Human   919 RKWHDKGE---------LLCHLE---------------------TQVKEVKEKFENKEKKLKAER 953

  Fly  1004 DDIIEGKKNDSAEDEFYSLEAMTTFGNLDAEFFQKLD-LQKVNASEDSEPAINCMRSYNELQAYM 1067
            |..||.:||           ||....::|..|.:::| :.:.:.:|.::.|       ||.|..:
Human   954 DKSIELQKN-----------AMEKLHSMDDAFKRQVDAIVEAHQAEIAQLA-------NEKQKCI 1000

  Fly  1068 KSGSLNT-QLNSEEAEMLQTMCSRVASDVDKPKSQNSKEEEEDDLLKKMVLRMKEYEE 1124
            .|.:|.. |:..|..|:|:..|            :|.|..|..  :|::...:.|.::
Human  1001 DSANLKVHQIEKEMRELLEETC------------KNKKTMEAK--IKQLAFALNEIQQ 1044

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dtr	NP_724335.2	leucine-rich repeat	38..57	CDD:275380	5/18 (28%)
		LRR_8	56..112	CDD:290566	22/55 (40%)
		LRR_4	56..98	CDD:289563	15/41 (37%)
		LRR_RI	58..>184	CDD:238064	46/133 (35%)
		leucine-rich repeat	58..79	CDD:275380	7/20 (35%)
		leucine-rich repeat	80..101	CDD:275380	8/20 (40%)
		LRR_8	100..161	CDD:290566	23/61 (38%)
		leucine-rich repeat	102..125	CDD:275380	11/22 (50%)
		leucine-rich repeat	126..147	CDD:275380	7/20 (35%)
		leucine-rich repeat	151..175	CDD:275380	9/23 (39%)
LRRCC1	XP_016869409.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910