Protein Alignment dtr and Cep97

DIOPT Version :10

• Sequence 1: NP_724335.2
• Gene: dtr / 318856
• FlyBaseID: FBgn0023090
• Length: 1483
• Species: Drosophila melanogaster
• Sequence 2: NP_083091.1
• Gene: Cep97 / 74201
• MGIID: 1921451
• Length: 856
• Species: Mus musculus
• Alignment Length: 895
• Identity: 176/895 - (19%)
• Similarity: 310/895 - (34%)
• Gaps: 285/895 - (31%)

  Fly    18 KGLKEL-----CKKDKLYQTPRLNDVLYLHYQGFQCIESLEEYTELKCLWLECNAISEIQGLEKL 77
            :||::|     |:.|........|.::.|        |:||:..:|..|.:..|.:..:.|:.||
Mouse    23 QGLQKLGANLPCEADVHTLILDKNQIIKL--------ENLEKCKQLIQLSVANNRLVRMMGVAKL 79

  Fly    78 SKLKCLFLQNNLITKIENLDPCRELDTLNLSSNHIRKIQNIGTNVLPVLNTLTISSNYLKDSESL 142
            ::|:.|.|.:|.|..:|.|.....|:.|||:.|:::.::.:  |....|..|.:|.|.:.....:
Mouse    80 TQLRVLNLPHNSIGCVEGLKDLVHLEWLNLAGNNLKTMEQV--NSCTALQHLDLSDNNIPQIGDV 142

  Fly   143 SDLIQCKT---------------------LSVLDLSNNRIDDILIVKIFEQMLNLKVLVLQGNPV 186
            |.||..||                     ||:|.|:.|.|.|:..:.....:..|:.|.:..||.
Mouse   143 SKLISLKTLLLHGNIITSLRMAPAYLPRNLSILSLAENEIRDLNEISFLASLSELEQLSIMNNPC 207

  Fly   187 VSRLP-----QYRKTLILACKELTYLDS-----------------------RP------------ 211
            |...|     .||..::..|..|..||.                       ||
Mouse   208 VMATPSIPGFDYRPFIVSWCLNLRVLDGYVISQKESLKAEWLYSQGKGRSYRPGQHIQLVQYLAT 272

  Fly   212 VFPRDRA----CAEAWKRDGYEGERKENNRWNRAERRKTRESINCTIRMRNSHRPPD-------- 264
            |.|...|    .||..|.:....:::.:.|...::.:....|....:..| .||.|:
Mouse   273 VCPLTSALGLQTAEDAKLEKILSKQRFHQRQLMSQSQDEELSPLAAVETR-VHRTPECSSPGQDF 336

  Fly   265 -QQDPLLRSS-----DSEDDT-------------CAETARKKVALENGCVDD-------LWEE-- 301
             :.:|:|:.:     .|.||.             .|..:|..:.||:...|:       |..|
Mouse   337 QESEPVLQINSWVGISSNDDQLYAVKNNFPAAAHAARYSRNDLHLEDIQTDEDKLNCSLLSSEST 401

  Fly   302 ----VSGEQPISE------DGTNSSSSLEDNDGTSSQDDLIAEKLSNRRTLEGRPTVLYETEVSN 356
                .||..|:|.      .|.|  ..|||:||.    |...:.|.|:...:.:...|::...|.
Mouse   402 FMPVASGLSPVSPTVELRLQGIN--LGLEDDDGA----DEFTKGLENQDEDKDKEKSLWDMSESC 460

  Fly   357 VKSANNDINIFEEGVGKASQIIIEDKPVTKIKLINEPSCMNDKSAMNC--TSMGPVVKENDFD-E 418
            |:.....|:   ..|.:|:.::    |..|..:|: .:...|..::..  .|.|......:.: |
Mouse   461 VEMLKRKIS---TEVSEAAGLL----PCPKSVIIS-AALKEDTHSLTSLPESAGHSASRTEANSE 517

  Fly   419 DAEIKNVDDMVPCQNLIK----------SNEDINSEFGFSSKLK--------QDFDQTCTALRND 465
            :|......:..||:.|.:          :.:.:|:.   ::||:        ::::|....:|.:
Mouse   518 EAMSPATSEKFPCRILTQRPAALGQDKVTLQKLNAA---ATKLQACWRGFYTRNYNQQAKGVRYE 579

  Fly   466 AE---------C---------KEFDEE--LTIKESESKPF--NEMYDIFAAEDDKLNETLDLNL- 507
            ..         |         ||.|||  .|..:.|:..|  ||:..:.|.:     :|::..|
Mouse   580 IRLRRMQEHIVCLTDEVRRLRKERDEERVKTFVQEEAVRFLWNEVRSVQAWQ-----QTVEQRLA 639

  Fly   508 ---------NETTC-------PHH------------VHDNFFSEQNKMPSFYEEDIMINL---LP 541
                     :.|..       |||            |.::..::....|.|.:.....:|   :|
Mouse   640 SWPPDVPPISSTLASPKPPLFPHHQDPSSDQSSDWLVAEDEAAQGRSAPDFPDSGFHSSLTEQVP 704

  Fly   542 KTKEKTLLEKDSIIENE-----------KCAHDLDEMGRQMEEDLAELRQSTQNLIGISIDETAR 595
            ..::....||.|:..:|           ||..|.|.                        :.||.
Mouse   705 CLQDSLDFEKSSVESSENSVLGNSADTVKCVKDRDS------------------------EATAE 745

  Fly   596 TDSETDEEDLIAQQDPYSPLLKQQFKDRRMKIMLTEETKAQEESLSD--RNIALSNESDQDDKQD 658
            ..|:...|...::||   ..|.||:.....::....|....::...|  |::|.|.|.
Mouse   746 EHSDCSRESSASEQD---NTLLQQYLTSVQQLDDAAEAADSDDVAGDGKRHLACSPER------- 800

  Fly   659 QLFAKILDDATENIPKRIFGTGCDALSSVWPQEECLLQLTLPENKESPAQ 708
                  .|.::::...|:..|..|.:|..  .|.|.|      |:|:..|
Mouse   801 ------FDASSDSETHRVASTSQDEISQT--PENCQL------NEEAQGQ 836

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dtr	NP_724335.2	leucine-rich repeat	38..57	CDD:275380	4/18 (22%)
		PPP1R42	39..225	CDD:455733	58/250 (23%)
		leucine-rich repeat	58..79	CDD:275380	6/20 (30%)
		leucine-rich repeat	80..101	CDD:275380	7/20 (35%)
		leucine-rich repeat	102..125	CDD:275380	6/22 (27%)
		leucine-rich repeat	126..147	CDD:275380	6/20 (30%)
		leucine-rich repeat	151..175	CDD:275380	7/23 (30%)
Cep97	NP_083091.1	leucine-rich repeat	17..37	CDD:275380	4/13 (31%)
		PPP1R42	18..242	CDD:455733	57/228 (25%)
		LRR 1	37..58		6/28 (21%)
		leucine-rich repeat	38..59	CDD:275380	5/28 (18%)
		LRR 2	59..80		5/20 (25%)
		leucine-rich repeat	60..81	CDD:275380	6/20 (30%)
		LRR 3	81..102		7/20 (35%)
		leucine-rich repeat	82..103	CDD:275380	7/20 (35%)
		LRR 4	103..124		6/22 (27%)
		leucine-rich repeat	104..125	CDD:275380	6/22 (27%)
		LRR 5	125..146		5/20 (25%)
		leucine-rich repeat	126..147	CDD:275380	6/20 (30%)
		LRR 6	147..168		2/20 (10%)
		leucine-rich repeat	148..171	CDD:275380	2/22 (9%)
		LRR 7	171..192		7/20 (35%)
		leucine-rich repeat	172..196	CDD:275380	7/23 (30%)
		LRR 8	196..205		2/8 (25%)
		CCP110-binding. /evidence=ECO:0000250	300..742		85/488 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	430..451		5/24 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	498..525		4/26 (15%)
		IQCD	547..575	CDD:467745	4/30 (13%)
		Interaction with MPHOSPH9. /evidence=ECO:0000250|UniProtKB:Q8IW35	579..853		57/311 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	646..672		4/25 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	737..840		28/148 (19%)