DRSC/TRiP Functional Genomics Resources

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Protein Alignment dtr and Ppp1r42

DIOPT Version :9

Sequence 1:NP_724335.2 Gene:dtr / 318856 FlyBaseID:FBgn0023090 Length:1483 Species:Drosophila melanogaster
Sequence 2:NP_663730.1 Gene:Ppp1r42 / 69312 MGIID:1921138 Length:357 Species:Mus musculus


Alignment Length:383 Identity:103/383 - (26%)
Similarity:161/383 - (42%) Gaps:83/383 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 NSNRKEITGLNRMTPKGLKELCKKDKLYQTPRLNDVLYLHY--QGFQCIESLEEYTELKCLWLEC 65
            |||.|         |:      |::.|.|.  |..:.::::  :....|:.|.....|..|:|..
Mouse    12 NSNLK---------PR------KEETLAQC--LKKITHINFSDRNIDSIDDLSLCRNLSVLYLYD 59

  Fly    66 NAISEIQGLEKLSKLKCLFLQNNLITKIENLDPCRELDTLNLSSNHIRKIQNI-GTNVLPVLNT- 128
            |.||::..|...:.|..|:||||.|:.||||...::|:.|.|..|:|..|:.: |...|..|:. 
Mouse    60 NRISQVTNLNYTTNLTHLYLQNNCISCIENLSSLKKLEKLYLGGNYIAVIEGLEGLEELRELHVE 124

  Fly   129 ---LTISSNYLKDSESLSDLIQCKTLSVLDLSNNRIDDILIVKIFEQM----------------- 173
               |.:....|.|..:|..|  .|:||.|::|||.||||..::|.|.:                 
Mouse   125 SQRLPLGEKLLFDPRTLRSL--AKSLSTLNISNNNIDDIKDLEILENLNHLIAVDNQLMHVKDLE 187

  Fly   174 LNLKVLV------LQGNPVVSRLPQYRKTLILACKELTYLDSRPVFPRDRACAEAWKRDGYEGER 232
            |.||.|:      |.||||..: |:||..|||..|.|.:||.:.:...:|.....||..      
Mouse   188 LLLKKLMKLWKMDLNGNPVCLK-PKYRDKLILTSKSLEFLDGKEIKDMERQFLMNWKAS------ 245

  Fly   233 KENNRWNRAERRKTRESINCTI-RMRNSHR------PPDQQDPLLRSSDSEDDTCAETARKKVAL 290
            |:..:.::..|.::.::.|..| .....|.      |...:..::..||.:.......|..|.:.
Mouse   246 KDAKKISKKRRSRSEDASNSYISNFETVHHIVPVYYPQVGKPKVIFFSDVQRYLVHGNASSKCSQ 310

  Fly   291 ENGCVDDLWEEVSGEQPISEDGTN-----SSSSLEDNDGTSS---QDDLIAEKLSNRR 340
            |:            :..|:||..|     |.|||..||....   |:..:.|.||.::
Mouse   311 ED------------KTTITEDIGNLSLKESESSLTKNDIHEPHLLQNPKVKENLSEKK 356

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dtrNP_724335.2 leucine-rich repeat 38..57 CDD:275380 2/20 (10%)
LRR_8 56..112 CDD:290566 22/55 (40%)
LRR_4 56..98 CDD:289563 18/41 (44%)
LRR_RI 58..>184 CDD:238064 50/153 (33%)
leucine-rich repeat 58..79 CDD:275380 7/20 (35%)
leucine-rich repeat 80..101 CDD:275380 11/20 (55%)
LRR_8 100..161 CDD:290566 21/65 (32%)
leucine-rich repeat 102..125 CDD:275380 8/23 (35%)
leucine-rich repeat 126..147 CDD:275380 6/24 (25%)
leucine-rich repeat 151..175 CDD:275380 12/40 (30%)
Ppp1r42NP_663730.1 LRR 1 29..50 2/20 (10%)
leucine-rich repeat 31..51 CDD:275380 2/19 (11%)
LRR_8 50..106 CDD:290566 22/55 (40%)
LRR 2 51..72 7/20 (35%)
LRR_4 72..>106 CDD:289563 15/33 (45%)
LRR 3 73..94 11/20 (55%)
leucine-rich repeat 74..95 CDD:275380 11/20 (55%)
LRR 4 95..116 7/20 (35%)
leucine-rich repeat 96..147 CDD:275380 14/52 (27%)
LRR 5 117..138 4/20 (20%)
LRR 6 147..168 11/20 (55%)
leucine-rich repeat 148..169 CDD:275380 11/20 (55%)
LRR 7 169..190 1/20 (5%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 329..357 9/28 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
21.870

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