DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dtr and Dnaaf1

DIOPT Version :9

Sequence 1:	NP_724335.2	Gene:	dtr / 318856	FlyBaseID:	FBgn0023090	Length:	1483	Species:	Drosophila melanogaster
Sequence 2:	NP_080924.1	Gene:	Dnaaf1 / 68270	MGIID:	1915520	Length:	634	Species:	Mus musculus

Alignment Length:	567	Identity:	182/567 - (32%)
Similarity:	280/567 - (49%)	Gaps:	121/567 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RMTPKGLKELCKKDKLYQTPRLNDVLYLHYQGFQCIESLEEYTELKCLWLECNAISEIQGLEKLS 78
            |||.:.|::|||:.|||.||.|||.||||::||..||:|||||.|:|||||||.|..|:.|:..|
Mouse    81 RMTKQFLQKLCKQHKLYVTPALNDTLYLHFKGFDRIENLEEYTGLRCLWLECNGIQRIENLQAQS 145

  Fly    79 KLKCLFLQNNLITKIENLDPCRELDTLNLSSNHIRKIQNIGTNVLPVLNTLTISSNYLKDSESLS 143
            :|:|||||.||:.|||||:|.::||.||||:|:|:.|:|:  :.|||||||.::.|.|:....:.
Mouse   146 ELRCLFLQVNLLHKIENLEPLQKLDALNLSNNYIKTIENL--SCLPVLNTLQMAHNRLETVADIE 208

  Fly   144 DLIQCKTLSVLDLSNNRIDDILIVKIFEQMLNLKVLVLQGNPVVSRLPQYRKTLILACKELTYLD 208
            .|.:|..|.|||||:|.:.|..|:.:.|.|..|:||.|.||||...:|.||:|:.:..|.|||||
Mouse   209 HLRECLRLCVLDLSHNALSDPEILSVLESMPCLRVLNLMGNPVTKHIPNYRRTVTVRLKHLTYLD 273

  Fly   209 SRPVFPRDRACAEAWKRDGYEGERKENNRWNRAERRKTRESIN--CTIRMRNSHRP--------- 262
            .|||||:||||||||.|.||..|::|..:|...|.:|..:|:.  ..|:.|...|.
Mouse   274 DRPVFPKDRACAEAWARGGYAAEKEERRQWESREHKKITDSLEALAMIKRRAEERKKARDRGETP 338

  Fly   263 -PDQQDPLLRSSDSEDDTCAETARKK---------------------------VALENGCVDDLW 299
             ||.:..:..|.::|:.......:||                           |.:.||.|::
Mouse   339 LPDSEGSIPTSPEAEEKQPMGEIQKKMELFVEESFEAKDELFPETPGGEKELHVVVVNGAVEN-- 401

  Fly   300 EEVSG-----EQPISEDGTNSSSSLEDNDGTSSQD-DLIAEKLSNRRTLEGRPTV---------- 348
            .::||     :.|:......|:|.:...||..::| :.:|.::..|..::..|.:
Mouse   402 PDLSGSLAHNQTPVVVTPEESTSPVAATDGARTEDIEAVAVEIKERLFIDDLPDLEDAEGTDVSV 466

  Fly   349 ---LYETEVSNVKS-----------------------------ANNDINIFEEGVGKASQIIIED 381
               :.||::..:::                             |.:.|....:|...|:.:...|
Mouse   467 EDQIKETDIPRIQAISSLSDDSDPELDELSLSTSEATPTGATGALSHIFAISKGPSTAATVPFTD 531

  Fly   382 --KPVTKIKLINEPSCMNDKSAMNC--TSMGPVVKENDFDEDAEIKNVDDMVPCQN------LIK 436
              ||:....|        :....:|  .:..|:::|.: ||.|| :..:..:|.|.      |..
Mouse   532 ICKPIATTDL--------ESQGQDCGAAASRPLIQELN-DEPAE-EAANQPLPPQTCASDPALAH 586

  Fly   437 SNEDINSEFGFSSKLKQDFDQTCTALRNDAECKEFDEELTIKESESK 483
            .:||.:|:    |:|     ...|.|.:.|| .|.:..:..||..::
Mouse   587 PSEDGDSD----SQL-----PAATLLGDGAE-DEAESSVHPKEPSTR 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dtr	NP_724335.2	leucine-rich repeat	38..57	CDD:275380	12/18 (67%)
		LRR_8	56..112	CDD:290566	34/55 (62%)
		LRR_4	56..98	CDD:289563	26/41 (63%)
		LRR_RI	58..>184	CDD:238064	62/125 (50%)
		leucine-rich repeat	58..79	CDD:275380	11/20 (55%)
		leucine-rich repeat	80..101	CDD:275380	14/20 (70%)
		LRR_8	100..161	CDD:290566	28/60 (47%)
		leucine-rich repeat	102..125	CDD:275380	11/22 (50%)
		leucine-rich repeat	126..147	CDD:275380	7/20 (35%)
		leucine-rich repeat	151..175	CDD:275380	11/23 (48%)
Dnaaf1	NP_080924.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..80
		LRR 1	101..123		14/21 (67%)
		leucine-rich repeat	105..124	CDD:275380	12/18 (67%)
		LRR_RI	<116..>252	CDD:238064	72/137 (53%)
		LRR 2	124..145		11/20 (55%)
		LRR_8	145..201	CDD:290566	33/57 (58%)
		LRR 3	146..167		14/20 (70%)
		leucine-rich repeat	147..168	CDD:275380	14/20 (70%)
		LRR 4	168..189		10/22 (45%)
		leucine-rich repeat	169..190	CDD:275380	11/22 (50%)
		LRR_8	189..251	CDD:290566	27/61 (44%)
		LRR 5	190..211		7/20 (35%)
		leucine-rich repeat	191..215	CDD:275380	8/23 (35%)
		LRR 6	215..236		9/20 (45%)
		leucine-rich repeat	216..237	CDD:275380	9/20 (45%)
		leucine-rich repeat	241..268	CDD:275380	12/26 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	326..358		5/31 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..505		0/23 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..634		20/77 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838513
Domainoid	1	1.000	118	1.000	Domainoid score	I5867
eggNOG	1	0.900	-	-		E1_2CMIN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007930
OrthoInspector	1	1.000	-	-		oto93019
orthoMCL	1	0.900	-	-		OOG6_102611
Panther	1	1.100	-	-	LDO	PTHR45973
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4530
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.770