DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dtr and TbCMF46

DIOPT Version :9

Sequence 1:	NP_724335.2	Gene:	dtr / 318856	FlyBaseID:	FBgn0023090	Length:	1483	Species:	Drosophila melanogaster
Sequence 2:	NP_609325.2	Gene:	TbCMF46 / 34318	FlyBaseID:	FBgn0032163	Length:	566	Species:	Drosophila melanogaster

Alignment Length:	674	Identity:	152/674 - (22%)
Similarity:	243/674 - (36%)	Gaps:	224/674 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 KKDKLYQTPRLNDVLY-------LHYQGFQCIESLEEYTELKCLWLECNAISEIQGLEKLSKLKC 82
            ||.:..:..:|..|:|       |.::....|:.|.....|..|.|.||.|..|:.||.|:.||.
  Fly    51 KKGEARRLHQLEPVVYDRITTMRLEFKNILRIDHLWMMPNLTKLCLNCNKIEVIEHLEMLTALKD 115

  Fly    83 LFLQNNLITKIENLDPCRELDTLNLSSNHIRKIQNIGTNVLPVLNTLTISSNYLKDSESLSDLIQ 147
            |.|..|.||:||||:...:|:.|:|.||.||||:||.|                     |.:|:
  Fly   116 LNLSFNYITRIENLEKLVKLEKLSLFSNRIRKIENIHT---------------------LQNLV- 158

  Fly   148 CKTLSVLDLSNNRIDDILIVKIFEQMLNLKVLVLQGNPVVSRLPQYRKTL--ILACKELTYLDSR 210
                 :|.:.||.||.:..::....:.:||||.|:||| :::.|.:..:|  |....:|.|.:.
  Fly   159 -----ILSIGNNLIDTVEGIERLRFVSSLKVLNLEGNP-IAKQPDFPLSLYVIAILPQLNYYEY- 216

  Fly   211 PVFPRDRACAEAWKRDGYEGERKENNRWNRAERRKTRESINCTIRMRNSHRPPDQQDPLLRSSDS 275
             ||.:.....||.||                ..|:.||.             .|:|:..::..::
  Fly   217 -VFIKTETREEAQKR----------------FYRELREI-------------EDKQEREIQGLET 251

  Fly   276 EDDTCAETARKKVALENGCVDDLWEEVSGEQPISEDGTNSSSSLEDNDGTSSQDDLIAEKLSNRR 340
            |....||..|.                            :||.:|..||....|.|.      |.
  Fly   252 EAREMAEADRL----------------------------ASSFVEHLDGMQLYDSLW------RD 282

  Fly   341 TLEGRPTVLYETEVSNVKSANNDINIFEEGVGKASQIIIED--KPVTKIKLINEPSCMNDKSAMN 403
            ..:||..:|                     ||..:|.:.|:  |.|.::             ...
  Fly   283 DEDGRILML---------------------VGAPAQELCEEYSKDVYEL-------------TQQ 313

  Fly   404 CTSMGPVVKENDFDEDAEIKNVDDMVPCQNLIKSNEDINSEFGFSSKLKQDFDQTCTALRNDAEC 468
            ...:|   .|...:.|.||::.:     .||.:..|::.::   ..:..:||          .|.
  Fly   314 IYRLG---LERFGERDEEIRDFN-----ANLHEGQEELQAQ---GQRQIEDF----------LEY 357

  Fly   469 KE--FDE------ELTIKESESKPFNEMYDIFAAE-DDKLNE------TLDLNLNETTCPHHVHD 518
            ||  |||      ||..::.:.:......|...|. :|.|||      ..:|:|:|.     |.|
  Fly   358 KERIFDEMRLKWRELDQRDDDLEQLQAQLDTLTANFEDSLNELWESLMAQELHLHEA-----VED 417

  Fly   519 NFFSEQNKMPSFYEEDIMINLLPKTKEKTLLEKDSIIENEKCAHDLDEMGRQMEEDLAELRQSTQ 583
            :......|:     .|:|.|.:.:.:...|..:|      .|::..|.|     .|:.....||
  Fly   418 STLKFNRKI-----SDLMSNFVEQAQVIFLQLRD------LCSYFADNM-----TDIVNQFLST- 465

  Fly   584 NLIGISIDETARTDSETDEEDLIAQQDPYSPLLKQQFKDRRMKIMLTEETKAQEESLSDRNIALS 648
                    :.||.:..|..|:           |||...||...:.|.|..:....|..|:
  Fly   466 --------KLARNELNTIPEE-----------LKQCVDDREAVLQLVEGMRTTHTSRVDK----- 506

  Fly   649 NESDQDDKQDQLFAKILDDATENI 672
                ::|:..|...:.:||...|:
  Fly   507 ----REDRLAQRSRQFIDDMITNL 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dtr	NP_724335.2	leucine-rich repeat	38..57	CDD:275380	5/25 (20%)
		LRR_8	56..112	CDD:290566	26/55 (47%)
		LRR_4	56..98	CDD:289563	21/41 (51%)
		LRR_RI	58..>184	CDD:238064	45/125 (36%)
		leucine-rich repeat	58..79	CDD:275380	10/20 (50%)
		leucine-rich repeat	80..101	CDD:275380	11/20 (55%)
		LRR_8	100..161	CDD:290566	17/60 (28%)
		leucine-rich repeat	102..125	CDD:275380	12/22 (55%)
		leucine-rich repeat	126..147	CDD:275380	2/20 (10%)
		leucine-rich repeat	151..175	CDD:275380	5/23 (22%)
TbCMF46	NP_609325.2	leucine-rich repeat	69..90	CDD:275378	3/20 (15%)
		LRR_8	89..145	CDD:290566	26/55 (47%)
		LRR_4	89..131	CDD:289563	21/41 (51%)
		leucine-rich repeat	91..112	CDD:275378	10/20 (50%)
		leucine-rich repeat	113..134	CDD:275378	11/20 (55%)
		LRR_8	134..192	CDD:290566	27/85 (32%)
		LRR_4	134..174	CDD:289563	19/66 (29%)
		leucine-rich repeat	135..156	CDD:275378	13/41 (32%)
		leucine-rich repeat	157..181	CDD:275378	6/29 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447147
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45973
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940