DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dtr and Ppr-Y

DIOPT Version :9

Sequence 1:	NP_724335.2	Gene:	dtr / 318856	FlyBaseID:	FBgn0023090	Length:	1483	Species:	Drosophila melanogaster
Sequence 2:	NP_001015502.3	Gene:	Ppr-Y / 3355180	FlyBaseID:	FBgn0046697	Length:	569	Species:	Drosophila melanogaster

Alignment Length:	721	Identity:	151/721 - (20%)
Similarity:	254/721 - (35%)	Gaps:	251/721 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSNSNRKEITGLNRMTPKGLKELCKKDKLYQTPRL--NDVLYLHYQGFQCIESLEEYTELKCLWL 63
            :.:.:|.|...|:::.|..|:::.       |.||  |::|.        |:.|.....|..|.|
  Fly    39 LKHVHRGEGRRLHQLEPVVLEQIL-------TMRLEFNNILR--------IDHLWILPNLTKLCL 88

  Fly    64 ECNAISEIQGLEKLSKLKCLFLQNNLITKIENLDPCRELDTLNLSSNHIRKIQNIGTNVLPVLNT 128
            .||.|..|:.:|.|:.||.|.|..|.|.||||||....|:.|:|.||.|..|:||        :.
  Fly    89 NCNKIETIENIEMLTNLKDLNLSFNFIEKIENLDTLVNLEVLSLFSNKIEAIENI--------DM 145

  Fly   129 LTISSNYLKDSESLSDLIQCKTLSVLDLSNNRIDDILIVKIFEQMLNLKVLVLQGNPVVSR---- 189
            ||:                   |.::.|.||.||.:..::.|..|.|||::.|:|||:..|
  Fly   146 LTM-------------------LVIISLGNNLIDTVEGIERFRFMNNLKIINLEGNPIAKRTNFC 191

  Fly   190 LPQYRKTLILACKELTYLDSRPVFPRDRACAEAWKRDGYEGERKENNRWNRAERRKTRESINCTI 254
            |.:|...::   .:|.|.:.  .|.:....|||                             |.:
  Fly   192 LLKYISAIL---PKLNYYEY--TFIKSELRAEA-----------------------------CNL 222

  Fly   255 RMRNSHRPPDQQDPLLRSSDSEDDTCAETARKKVALENGCVDDLWEEVSGEQPISEDGTNSSSSL 319
            ..|......|:|:..::            |||.:                |:..||....:||.:
  Fly   223 YYREIREIEDKQEKEIQ------------ARKFL----------------EREQSEAKRLASSFV 259

  Fly   320 EDNDGTSSQDDLIAEKLSNRRTLEGRPTVLYETEVSNVKSANNDINIFEEGVGKASQIIIEDKPV 384
            |..||....|.|.      |...:||..:|..|:...: :...|.:|||           ..:.:
  Fly   260 EHLDGHQLFDSLW------RGDEDGRVLMLVGTQAQEL-ADEYDKDIFE-----------LTQEI 306

  Fly   385 TKIKLINEPSCMNDKSAMNCTSMGPVVKENDFDEDAEIKNVDDMVPCQNLIKSNEDIN------- 442
            .|:.|                       |...:.|.||::.     ..||....|::.
  Fly   307 YKLGL-----------------------ERFTERDEEIRDF-----FNNLFDGQEELQILGQNEI 343

  Fly   443 ------SEFGFSS------KLKQDFDQTCTALRNDAECKEFDEELTIKESESK-------PFNEM 488
                  .|..|..      ||:|:        ....|.::..|.|.:.::..|       ..|::
  Fly   344 EWFLQFREIIFEEARIRLLKLEQN--------SMHGEDEDTPENLKLSDALDKLNIQFEDAINDL 400

  Fly   489 YDIFAAEDDKLNETLDLNLNETTCPHH----------VHDN--FFSEQNKMPSFYEEDIMINLLP 541
            :....|::..|:|    ::.|:|...|          |..:  ||.:..::...:.|: |..:|.
  Fly   401 WQALMAQELYLHE----SIQESTINFHRKIAELMSKFVEQSQAFFVQLREITLHFSEN-MTEILT 460

  Fly   542 K--TKEKTLLEKDSI-IENEKCAHDLDEMGRQMEEDLAELRQSTQNLI-GISIDETARTDSETDE 602
            :  :.:..|.:.|.: ||...|..|               |.:..||| |:....|.|.|   :.
  Fly   461 RFISTKFALQDFDDVPIELRVCVDD---------------RDAILNLIAGMKDYHTLRLD---ER 507

  Fly   603 EDLIAQQDPYSPLLKQQFKDRRMKIMLTEETKAQEESLSDRNIALSNESDQDDKQDQLFAKILDD 667
            ||.||.:       .::|.|..:..:.:.|.:.....:.:.|               .|.:::.|
  Fly   508 EDTIATR-------TKEFVDNMIDQLNSNEVERHRSKILEIN---------------FFVEMMTD 550

  Fly   668 ATENIP 673
            |..::|
  Fly   551 AMTSLP 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dtr	NP_724335.2	leucine-rich repeat	38..57	CDD:275380	3/18 (17%)
		LRR_8	56..112	CDD:290566	26/55 (47%)
		LRR_4	56..98	CDD:289563	20/41 (49%)
		LRR_RI	58..>184	CDD:238064	44/125 (35%)
		leucine-rich repeat	58..79	CDD:275380	9/20 (45%)
		leucine-rich repeat	80..101	CDD:275380	12/20 (60%)
		LRR_8	100..161	CDD:290566	15/60 (25%)
		leucine-rich repeat	102..125	CDD:275380	9/22 (41%)
		leucine-rich repeat	126..147	CDD:275380	2/20 (10%)
		leucine-rich repeat	151..175	CDD:275380	8/23 (35%)
Ppr-Y	NP_001015502.3	leucine-rich repeat	63..82	CDD:275378	7/26 (27%)
		LRR_8	81..137	CDD:290566	26/55 (47%)
		LRR_4	81..121	CDD:289563	18/39 (46%)
		leucine-rich repeat	83..104	CDD:275378	9/20 (45%)
		LRR_4	103..143	CDD:289563	19/39 (49%)
		leucine-rich repeat	105..126	CDD:275378	12/20 (60%)
		LRR_8	126..184	CDD:290566	25/84 (30%)
		LRR_4	126..166	CDD:289563	17/66 (26%)
		leucine-rich repeat	127..148	CDD:275378	10/28 (36%)
		leucine-rich repeat	149..162	CDD:275378	6/12 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447146
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45973
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940