DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dtr and tilB

DIOPT Version :9

Sequence 1:	NP_724335.2	Gene:	dtr / 318856	FlyBaseID:	FBgn0023090	Length:	1483	Species:	Drosophila melanogaster
Sequence 2:	NP_608460.1	Gene:	tilB / 33130	FlyBaseID:	FBgn0014395	Length:	395	Species:	Drosophila melanogaster

Alignment Length:	342	Identity:	85/342 - (24%)
Similarity:	132/342 - (38%)	Gaps:	88/342 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 KELCKKDKLYQTPRLNDVL---YLHYQGFQCIESLEEYTELKCLWLECNAISEIQGLEKLSKLKC 82
            :||.:| |.....||...|   .||.:..:.||.::.:         |.            .||.
  Fly     6 EELVRK-KSEHNERLISTLEEISLHQEDIEVIEHIQNW---------CR------------DLKI 48

  Fly    83 LFLQNNLITKIENLDPCRELDTLNLSSNHIRKIQNIGTNVLPVLNTLTISSNYLKDSESLSDLIQ 147
            |.||:|||.::|||...:.|:.||::.|:|.:::|                           |..
  Fly    49 LLLQSNLIARLENLHKLKRLEYLNVAINNIERVEN---------------------------LEG 86

  Fly   148 CKTLSVLDLSNNRIDDILIVKIFEQMLNLKVLVLQGNPVVSRLPQYRKTLILACKELTYLDSRPV 212
            |::||.|||:.|.|.::..|:......||:.|||.|||.|. .|.||..::....:|..||...:
  Fly    87 CESLSKLDLTLNFIRELTSVESLCGNYNLRELVLIGNPCVD-YPHYRDYVVATLPQLNSLDCVEI 150

  Fly   213 FP--RDRACAEAWKRDGYEGERKENNRWNRAERRKTRESINCTIRMRNSHRPPDQQDPLLRSSDS 275
            .|  |.||..|..|......:::......|.|:|         ||:..      ||..|......
  Fly   151 TPSERLRALRELSKNRSIIVQKQVEQDIERDEQR---------IRVAK------QQSALAEHCAG 200

  Fly   276 EDDTCAETARKKV---ALENGCVDDLWEEVSGEQPISEDGTNSSSSLEDNDGTSSQDDLIAEKLS 337
            .:|   |..|.|.   |....| .::..|::.:..:..:...:.|.|   |....|.:|.|..
  Fly   201 IED---EEERIKAFWQAKSEHC-PEIRTEIARQHRLGRERHETKSPL---DPLKPQRNLFAPC-- 256

  Fly   338 NRRTLEGRPTVLYETEV 354
                  |||..|.:.::
  Fly   257 ------GRPYNLNQAKL 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dtr	NP_724335.2	leucine-rich repeat	38..57	CDD:275380	5/21 (24%)
		LRR_8	56..112	CDD:290566	16/55 (29%)
		LRR_4	56..98	CDD:289563	12/41 (29%)
		LRR_RI	58..>184	CDD:238064	33/125 (26%)
		leucine-rich repeat	58..79	CDD:275380	1/20 (5%)
		leucine-rich repeat	80..101	CDD:275380	11/20 (55%)
		LRR_8	100..161	CDD:290566	14/60 (23%)
		leucine-rich repeat	102..125	CDD:275380	6/22 (27%)
		leucine-rich repeat	126..147	CDD:275380	1/20 (5%)
		leucine-rich repeat	151..175	CDD:275380	8/23 (35%)
tilB	NP_608460.1	LRR_9	1..174	CDD:258718	60/217 (28%)
		leucine-rich repeat	23..45	CDD:275378	6/42 (14%)
		LRR_4	46..86	CDD:289563	18/66 (27%)
		leucine-rich repeat	46..67	CDD:275378	11/20 (55%)
		leucine-rich repeat	68..89	CDD:275378	8/47 (17%)
		leucine-rich repeat	90..114	CDD:275378	8/23 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447142
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840