DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dtr and Lrrc43

DIOPT Version :9

Sequence 1:	NP_724335.2	Gene:	dtr / 318856	FlyBaseID:	FBgn0023090	Length:	1483	Species:	Drosophila melanogaster
Sequence 2:	NP_001163867.1	Gene:	Lrrc43 / 288751	RGDID:	1561461	Length:	681	Species:	Rattus norvegicus

Alignment Length:	730	Identity:	144/730 - (19%)
Similarity:	236/730 - (32%)	Gaps:	235/730 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LKELCKKDKLYQTPRLNDVLYLHYQGFQCIESLE-----------EYTELKCLWLECNAISEIQG 73
            |:||..::.|    .:.|..:..|  |:|:..::           ::.:|:.|.|..|.|.:|..
  Rat   104 LRELAIQNPL----TIKDTFFYSY--FRCLRVVDKGVSLVDKEILKFLKLEELVLSANKIKDIDA 162

  Fly    74 LEKLSKLKCLFLQNNLITKIENL--DPCRELDTLNLSSNHI---RKIQNIGTNVLPVLNTLTISS 133
            ......||.|.|..|||..:|.|  .|...|..|.|..|.:   .:...:.:|..|:|.:|.:..
  Rat   163 NNLPPTLKVLELYGNLIASMECLCSPPPPNLQHLGLGHNKLLGPLESLYVTSNNWPLLVSLDLGF 227

  Fly   134 NYLKDSESLSDLIQCKTLSVLDLSNNRIDDILIVKIFEQMLNLKVLVLQGNPVVSRLPQYRKTLI 198
            |.|.|.:|:          :|.||..:.              |::||||||| ::.:|.||...:
  Rat   228 NDLTDLQSM----------ILGLSTLKC--------------LRLLVLQGNP-LALVPYYRGFTV 267

  Fly   199 LACKELTYLDSRPVFPRDRACAEAWKRDGYEGERKENNRWNRAERRKTRESINCTIRMRNSHRPP 263
            .:...|..||...|.|.::                                          |:
  Rat   268 DSLARLCVLDDITVSPSEK------------------------------------------HQ-- 288

  Fly   264 DQQDPLLRSSDSEDDTCAETARKKVALEN--GCVDDLWEEVSGEQPISEDGTNSSSSL------- 319
                  .|..:|..|..|..|:..|.:.|  |.:|   ..:...:| ..||...|.|.
  Rat   289 ------FRGLNSHGDLLAREAQFVVTIGNVRGVLD---SSILDPEP-GPDGPFISYSYYVTYDFV 343

  Fly   320 --EDNDG-TSSQDDLIAEKLSNRRTLEGRPTVLYETEVSNVKSANNDINIFEEGVGKASQIIIED 381
              |:.:| ||..::|..:.:.:              |:....|..::....||...:..|.::.
  Rat   344 EDEEKEGITSGMEELHPDSVLD--------------EIDKPSSGMDEEEEEEEEEEEDRQEVLS- 393

  Fly   382 KPVTKIKLINEPSCMNDKSAMNCTSMGPVVKENDFDEDAEIKNVDDMVPCQNLIKSNEDINSEFG 446
              |.:.:..:.|.....:......|  |.|...:..|.. :|.::.|.         || :.|.|
  Rat   394 --VFQSQAHHRPVRQGGRHRFRPES--PEVMSRELSEYI-VKEMNQMA---------ED-SGESG 443

  Fly   447 FSSKLKQDFDQTCTALRNDAECKEFDEELTIKESESKPFNEMYDIFAAEDDKLNETLDLNLNETT 511
            .:                     |.||..|.....|.|..:..| .:.|..||...||:.|
  Rat   444 IT---------------------EVDESETSISIHSAPLPQSID-SSEELAKLRPRLDVRL---- 482

  Fly   512 CPHHVHDNFFSEQNK-----MPSFYE------------------------EDIMIN--LLPKTKE 545
            || ......||..:|     :|..||                        |:.:|:  ::|...|
  Rat   483 CP-SPGTVLFSTMHKPWADVIPCTYEMKHTLKELIRVKAFLLSGTTVSIVEEKIISWPVVPTPVE 546

  Fly   546 KTLLEKDSIIENEKCAHDLDEMG-RQMEEDLAELRQS-----------------------TQNLI 586
            ..|..|....:.:|......:.| |:.:|...||||.                       ...:.
  Rat   547 SPLPAKKGKGDKKKKEEPAKDKGPRKKKEPPRELRQDPPVLRVLGSGQVYLEPLLAGEPVVSTVC 611

  Fly   587 GISIDETARTDSETDEEDLIAQQDPYSPLLKQQFKDRRMKIMLTEETKAQEESLSDRNIALSNES 651
            ...:..|..||..|...|       ...:.|...||:......|.|:..|.|.||   :.:..:.
  Rat   612 NFGVARTLETDRLTYARD-------SKKVKKGSKKDKSKAAAPTVESGYQPEPLS---VEVQIQL 666

  Fly   652 DQDDKQDQLFAKILD 666
            .|....::.|..::|
  Rat   667 HQYRSVEEAFLSLID 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dtr	NP_724335.2	leucine-rich repeat	38..57	CDD:275380	3/29 (10%)
		LRR_8	56..112	CDD:290566	20/57 (35%)
		LRR_4	56..98	CDD:289563	15/43 (35%)
		LRR_RI	58..>184	CDD:238064	36/130 (28%)
		leucine-rich repeat	58..79	CDD:275380	6/20 (30%)
		leucine-rich repeat	80..101	CDD:275380	10/22 (45%)
		LRR_8	100..161	CDD:290566	15/63 (24%)
		leucine-rich repeat	102..125	CDD:275380	5/25 (20%)
		leucine-rich repeat	126..147	CDD:275380	6/20 (30%)
		leucine-rich repeat	151..175	CDD:275380	3/23 (13%)
Lrrc43	NP_001163867.1	LRR_RI	<146..254	CDD:238064	36/131 (27%)
		LRR_8	146..203	CDD:290566	20/56 (36%)
		LRR_4	146..187	CDD:289563	15/40 (38%)
		leucine-rich repeat	147..168	CDD:275378	6/20 (30%)
		leucine-rich repeat	169..192	CDD:275378	10/22 (45%)
		LRR_8	191..256	CDD:290566	23/89 (26%)
		leucine-rich repeat	193..219	CDD:275378	5/25 (20%)
		leucine-rich repeat	220..245	CDD:275378	9/34 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910