DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dtr and Lrrcc1

DIOPT Version :9

Sequence 1:	NP_724335.2	Gene:	dtr / 318856	FlyBaseID:	FBgn0023090	Length:	1483	Species:	Drosophila melanogaster
Sequence 2:	NP_001094115.3	Gene:	Lrrcc1 / 266808	RGDID:	628722	Length:	1025	Species:	Rattus norvegicus

Alignment Length:	1241	Identity:	259/1241 - (20%)
Similarity:	466/1241 - (37%)	Gaps:	380/1241 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 KELCKKDK-LYQTPRLN-----DVLYLHYQGFQCIESLEEYTELKCLWLECNAISEIQGLEKLSK 79
            :::|..|| |:....|:     ..:.||......|.|::....|:.|.|..|.||:|:||..|:|
  Rat    19 EDVCFMDKGLHSISELSLDSSLHAINLHCNNISKITSIDHIWNLRHLDLSSNQISQIEGLNTLTK 83

  Fly    80 LKCLFLQNNLITKIENLDPCRELDTLNLSSNHIRKIQNIGTNVLPV------LNTLTISSNYLKD 138
            |..|.|..||||::|.|:....|..||||.|||..:    :.::|:      |..:.:.|||:
  Rat    84 LCTLNLSCNLITRVEGLEALVNLTRLNLSYNHISDL----SGLIPLHGLKYKLRYIDLHSNYI-- 142

  Fly   139 SESLSDLIQCKTLSVLDLSNNRIDDILIVKIFEQMLNLKVLVL----QGNPVVSRLPQYRKTLIL 199
             :|:..|:|| |:.:..|:|                    |:|    :||| :..:|.||..::.
  Rat   143 -DSIHHLLQC-TVGLHFLTN--------------------LILEKDGEGNP-ICLVPGYRAIILQ 184

  Fly   200 ACKELTYLDSRPVFPRDRACAEAWKRDGYEGERKENNRWNRAERRKTRESINCTIR--------- 255
            ...:|..||.:.:|                ||.......|.:..:.....::..:.
  Rat   185 TLPQLRILDCKNIF----------------GEPVSLEEMNSSHLQCFEGLLDNLVSSDSPLNISE 233

  Fly   256 ---MRNSHRPP-DQQDPLLRSSDSEDD-------TCAETARKKVALENGCVDDLWEEVSGEQPIS 309
               :.|...|| |...||...:.:.::       :...:..:|:..||...:::..:...:| |.
  Rat   234 DEVVDNMSAPPIDVLPPLEEFTSTPEENVLTSLLSACSSEPEKINHENNFQNEMKLQKLDDQ-IL 297

  Fly   310 EDGTNSSSSLEDN------------DGTSSQDDLIAEKLSNR----RTLEGRPTVLYETE-VSNV 357
            :....:::||.||            |.||..|      ..||    |.:..|..:.|.|. :.::
  Rat   298 QLLNETNNSLIDNVPEKDLRPKRDTDITSESD------YGNRKECSRKVSRRTKIPYYTRTIQSI 356

  Fly   358 KSANNDINIFEEGVGKASQIIIEDKPVTKIKLINEPSCMNDKSAMNCTSMGPVVKENDFDEDAEI 422
            |..|.:...|.....|..|..:.|..|.             .|.:||.::    :|.|..::..|
  Rat   357 KHHNKNNGAFVSCNRKMRQPYLRDLYVR-------------SSLVNCNNL----REVDEQKNGMI 404

  Fly   423 KNVDDMVPCQNLIKSNEDINSEFGFSSKLKQDFDQTCTALRNDAECKEFDEELTIKESESKPFNE 487
            | ||         ||..:.|:......:|.|:.:....|.:.:.:..::.:||      .|..||
  Rat   405 K-VD---------KSASNDNTYRSLVEQLDQEREMRWKAEQTEKKLMDYIDEL------HKQANE 453

  Fly   488 MYDIFA---AEDDKLNETLDLNLNETTCPHHVHDNFFSEQNKMPSF---------YEEDIMINLL 540
            ..|:.:   ...|:|.:.:   ..|..|...:.......||::...         .:||.:.:|
  Rat   454 KKDVHSQAIITTDRLKDAI---FKERHCKAQLEVIVHRLQNEIKKLTIELMKARDQQEDHIRHL- 514

  Fly   541 PKTKEKTLLEKDSIIENEKCAHDLDEMGRQMEEDLAELRQSTQ----NLIGISIDETARTDSETD 601
             :|.|:. |||   :|.:|......:| |.::|  .||:.|..    ||:..|:    |.:.|..
  Rat   515 -RTLERA-LEK---MEKQKAQQQQAQM-RLIQE--VELKASAADREINLLRTSL----RQEKEQV 567

  Fly   602 EE--DLIAQQDPYSPLLKQQ----------------FKDRRMKIMLTEETKAQEESLS-DRNIAL 647
            ::  ||:|        ||:|                |:|...|.:..||.|.::|... ...|.:
  Rat   568 QQLHDLLA--------LKEQEHRQEIETREFFNDAEFQDALTKRLSKEERKHEQEVKEYQEKINI 624

  Fly   648 SNESDQDDKQDQLFA--------KILDDATENIPKRIFGTGCDALSS---VWPQEECLLQLTLPE 701
            .|:...|.:.:...|        |.:.|..|::...:      |.|.   :|.|.:        |
  Rat   625 LNQQYLDLENEFRIALTVEARRFKDVQDGFEDVATEL------AKSKHALIWAQRK--------E 675

  Fly   702 NKESPAQEDTFKKSITNSTSFEKA--NEICVRMDQKMAEEEEALGKLLHDLEGEINN----VYDI 760
            |:.|     :..|.:|:....:|.  :|:|     |:.:|..|      :|:.:||.    :.|.
  Rat   676 NESS-----SLIKDLTSMVKEQKTKLSEVC-----KLKQEAAA------NLQNQINTLEILIEDD 724

  Fly   761 NTK------VKYEENTSTNESDAVSICTSLLDDIIVGL-TFDEVLCHEKPKSFEFGLIESDEEFS 818
            ..|      :|:|:|...:|..|       .:.:|.|| |..:|..||        |.......|
  Rat   725 KQKSIQIELLKHEKNQLISELAA-------KESLIYGLRTERKVWGHE--------LAYQGTSLS 774

  Fly   819 YS---FEPKLEKLVPPALEDPARGKSLRECLDTFSDFVSSMADPKLPVMLGRNPTSGVEKI---- 876
            .|   .|.::|.|.       ...:|||:..::..|.:      ::...:..:.|..:.|:
  Rat   775 QSRGKLEAQIESLC-------RENESLRKTHESDCDAL------RIKCKIIEDQTETIRKLKDGL 826

  Fly   877 --RAAQELLKTKNLSDLYKDTAESLN---SQVAKEIEKRKRRVAASATRCFNQR-DKYDDTLELV 935
              :..|..:..:.::.:.|.:.|.||   ||:...:||.:|.         |:| :|....|:..
  Rat   827 QEKDGQIKMLQEQITIIEKCSQEQLNEKTSQLDSIVEKLERH---------NERKEKLKQQLKAK 882

  Fly   936 ENRLMIVKK----------DSGDLEELPPPPPLISDTESEDDNPTEDNYTPGNEVHRHGTKTQDS 990
            |..|..::|          |.|:         |:|:.|                     |:.::.
  Rat   883 ELELEEIRKAYSTLNKKWHDKGE---------LLSNLE---------------------TQVKEV 917

  Fly   991 KEHLMSNLLNQNQDDIIEGKKNDSAEDEFYSLEAMTTFGNLDAEFFQKLD-LQKVNASEDSEPAI 1054
            ||..      :|::..:..:::.|.|   ...:|:....|:|..|.:::| :.:.:.:|.::.|
  Rat   918 KEKF------ENKEKKLRAERDRSLE---LQKDAVEKLQNMDDAFKRQVDAIVEAHQTEITQLA- 972

  Fly  1055 NCMRSYNELQAYMKSGSLNT-QLNSEEAEMLQTMCSRVASDVDKPKSQNSKEEEE---------D 1109
                  ||.|.|::..:|.. |:..|...:|:..|            :|.|..||         .
  Rat   973 ------NEKQRYIECANLKVQQIEDEMRGLLEETC------------KNKKLMEEKIKQLACAIS 1019

  Fly  1110 DLLKKM 1115
            |:.|:|
  Rat  1020 DIQKEM 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dtr	NP_724335.2	leucine-rich repeat	38..57	CDD:275380	4/18 (22%)
		LRR_8	56..112	CDD:290566	26/55 (47%)
		LRR_4	56..98	CDD:289563	20/41 (49%)
		LRR_RI	58..>184	CDD:238064	42/135 (31%)
		leucine-rich repeat	58..79	CDD:275380	10/20 (50%)
		leucine-rich repeat	80..101	CDD:275380	9/20 (45%)
		LRR_8	100..161	CDD:290566	20/66 (30%)
		leucine-rich repeat	102..125	CDD:275380	8/22 (36%)
		leucine-rich repeat	126..147	CDD:275380	6/20 (30%)
		leucine-rich repeat	151..175	CDD:275380	2/23 (9%)
Lrrcc1	NP_001094115.3	PPP1R42	25..197	CDD:411060	59/200 (30%)
		leucine-rich repeat	40..61	CDD:275378	4/20 (20%)
		leucine-rich repeat	62..83	CDD:275378	10/20 (50%)
		leucine-rich repeat	84..105	CDD:275378	9/20 (45%)
		leucine-rich repeat	106..131	CDD:275378	9/28 (32%)
		leucine-rich repeat	132..145	CDD:275378	4/15 (27%)
		leucine-rich repeat	158..188	CDD:275380	10/50 (20%)
		Smc	426..>758	CDD:224117	82/398 (21%)
		Smc	<639..1020	CDD:224117	96/505 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910