DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dtr and DNAAF1

DIOPT Version :9

Sequence 1:	NP_724335.2	Gene:	dtr / 318856	FlyBaseID:	FBgn0023090	Length:	1483	Species:	Drosophila melanogaster
Sequence 2:	XP_011521155.1	Gene:	DNAAF1 / 123872	HGNCID:	30539	Length:	772	Species:	Homo sapiens

Alignment Length:	762	Identity:	235/762 - (30%)
Similarity:	337/762 - (44%)	Gaps:	180/762 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RMTPKGLKELCKKDKLYQTPRLNDVLYLHYQGFQCIESLEEYTELKCLWLECNAISEIQGLEKLS 78
            |||...|::|||:.|||.||.|||.||||::||..||:|||||.|:||||:.|.|.:|:.||..:
Human    87 RMTKSSLQKLCKQHKLYITPALNDTLYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQT 151

  Fly    79 KLKCLFLQNNLITKIENLDPCRELDTLNLSSNHIRKIQNIGTNVLPVLNTLTISSNYLKDSESLS 143
            :|:|||||.||:.|||||:|.::||.||||:|:|:.|:|:  :.|||||||.::.|:|:..|.:.
Human   152 ELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTIENL--SCLPVLNTLQMAHNHLETVEDIQ 214

  Fly   144 DLIQCKTLSVLDLSNNRIDDILIVKIFEQMLNLKVLVLQGNPVVSRLPQYRKTLILACKELTYLD 208
            .|.:|..|.|||||:|::.|..|:.|.|.|.:|:||.|.||||:.::|.||:|:.:..|.|||||
Human   215 HLQECLRLCVLDLSHNKLSDPEILSILESMPDLRVLNLMGNPVIRQIPNYRRTVTVRLKHLTYLD 279

  Fly   209 SRPVFPRDRACAEAWKRDGYEGERKENNRWNRAERRKTRESINCTI----RMRNSHRPPDQQDPL 269
            .|||||:||||||||.|.||..|::|..:|...||:|..:||....    |.....|..:.|:..
Human   280 DRPVFPKDRACAEAWARGGYAAEKEERQQWESRERKKITDSIEALAMIKQRAEERKRQRESQERG 344

  Fly   270 LRSSDSEDDTCAETARKKVALENGCVDDLWEEVSGEQPISEDGTNSSSSLED------------- 321
            :||        ||....:|.|.           .||...|:||.|..:|.|.
Human   345 MRS--------AEDNSPRVPLR-----------LGEMTSSDDGENVPASAEGKEEPPGDRETRQK 390

  Fly   322 -----NDGTSSQDDLIAEKLSNR------RTLEGRP---------TVLYETEVSNVKSANNDINI 366
                 .:...::|:|..||.|..      :..:|.|         |:|..:.| .||.
Human   391 MELFVKESFEAKDELCPEKPSGEEPPVEAKREDGGPEPEGTLPAETLLLSSPV-EVKG------- 447

  Fly   367 FEEGVGKASQIIIEDKPVTKIKLINEPSCMNDKSAMNCTSMGPV-VKENDFDEDAEIKNVDDMVP 430
             |:|.|:....:..:.|                     ....|| ||..|.|::.|     ..:|
Human   448 -EDGDGEPEGTLPAEAP---------------------PPPPPVEVKGEDGDQEPE-----GTLP 485

  Fly   431 CQNLIKSNEDINSEFGFSSKLK-QDFDQTCTALRNDAECKEFDEELTIKESESKPFNEMYD---- 490
            .:.|:.|.         ..|:| :|.|            :|.:..|..:.....|.....:
Human   486 AETLLLSP---------PVKVKGEDGD------------REPEGTLPAEAPPPPPLGAAREEPTP 529

  Fly   491 -------IFAAEDDKLN----ETLDLNLNETTCPHHVHDNFFSEQNKMPSFYEEDIMINLLPKTK 544
                   :|..|.|...    ||:.|...||.|...:.|  ..:.::.....|:..|  ..||.:
Human   530 QAVATEGVFVTELDGTRTEDLETIRLETKETFCIDDLPD--LEDDDETGKSLEDQNM--CFPKIE 590

  Fly   545 EKTLLEKDSIIENEKCAHDLDEMGRQMEEDLAELRQSTQNLIGISID--ETAR---TD--SETDE 602
            ..:.|..||..|       ||.....:.|:|.  ..:..|:..:|.|  :.||   ||  .:..:
Human   591 VISSLSDDSDPE-------LDYTSLPVLENLP--TDTLSNIFAVSKDTSKAARVPFTDIFKKEAK 646

  Fly   603 EDL-IAQQDPYSPL-LKQQFKDRRMKIMLTEETKAQEE-----SLSDRN---IALSNESDQDDKQ 657
            .|| |.:||..||. |.|:..|......|......|.:     |..||:   :|.|:........
Human   647 RDLEIRKQDTKSPRPLIQELSDEDPSGQLLMPPTCQRDAAPLTSSGDRDSDFLAASSPEMGFHHV 711

  Fly   658 DQ----------LFAKILDDATENIPKRIFGTGCDALSSVWPQEECL 694
            ||          |||.....|...:|..         |:..|.|.|:
Human   712 DQAGLELLTSGDLFASASQSAGITVPTE---------SAATPPETCV 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dtr	NP_724335.2	leucine-rich repeat	38..57	CDD:275380	12/18 (67%)
		LRR_8	56..112	CDD:290566	32/55 (58%)
		LRR_4	56..98	CDD:289563	24/41 (59%)
		LRR_RI	58..>184	CDD:238064	62/125 (50%)
		leucine-rich repeat	58..79	CDD:275380	10/20 (50%)
		leucine-rich repeat	80..101	CDD:275380	14/20 (70%)
		LRR_8	100..161	CDD:290566	29/60 (48%)
		leucine-rich repeat	102..125	CDD:275380	11/22 (50%)
		leucine-rich repeat	126..147	CDD:275380	8/20 (40%)
		leucine-rich repeat	151..175	CDD:275380	12/23 (52%)
DNAAF1	XP_011521155.1	leucine-rich repeat	111..130	CDD:275380	12/18 (67%)
		LRR_4	129..171	CDD:289563	24/41 (59%)
		LRR_8	151..207	CDD:290566	32/57 (56%)
		LRR_4	151..192	CDD:289563	24/42 (57%)
		leucine-rich repeat	153..174	CDD:275380	14/20 (70%)
		LRR_4	173..215	CDD:289563	20/43 (47%)
		leucine-rich repeat	175..196	CDD:275380	11/22 (50%)
		LRR_8	195..257	CDD:290566	29/61 (48%)
		leucine-rich repeat	197..221	CDD:275380	9/23 (39%)
		LRR_4	221..263	CDD:289563	20/41 (49%)
		leucine-rich repeat	222..243	CDD:275380	10/20 (50%)
		leucine-rich repeat	247..274	CDD:275380	12/26 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148393
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007930
OrthoInspector	1	1.000	-	-		oto89448
orthoMCL	1	0.900	-	-		OOG6_102611
Panther	1	1.100	-	-	LDO	PTHR45973
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4530
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.870