DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43394 and Mansc1

DIOPT Version :9

Sequence 1:	NP_001245938.1	Gene:	CG43394 / 318843	FlyBaseID:	FBgn0263256	Length:	948	Species:	Drosophila melanogaster
Sequence 2:	NP_080621.1	Gene:	Mansc1 / 67729	MGIID:	1914979	Length:	414	Species:	Mus musculus

Alignment Length:	468	Identity:	85/468 - (18%)
Similarity:	141/468 - (30%)	Gaps:	176/468 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 LEVSTMRPMESRMNTMAPYSGENSSAEMIDDA--STQKRVSKVDKPARDYYYEDAPEDEMVASTT 140
            |.:|.:.|..|        :|:|...:.::|.  ..|..:||..:.....:.  |.:::.:.:..
Mouse    13 LVISFLTPRSS--------AGQNCLTKSLEDVVIDIQSSLSKGIRGNEPIHL--ATQEDCIGACC 67

  Fly   141 A-------KVATTMIPEYVRQAKAERFPQRDQEHTSTDYI----EEDATKSVDEEPPADQF--YR 192
            :       |....||           |..|..:.....|:    .|||...    .||...  ||
Mouse    68 STKDIAGDKACNLMI-----------FDTRKTDRQPNCYLFFCPSEDACPL----KPAKGLVTYR 117

  Fly   193 VEQHEPIPQA--QVQQLPSRD--------------------KPKPFEYSSEDD---------YYD 226
            :.:..|:..|  .:|||...:                    .|||...|..|.         :..
Mouse   118 LIRDFPLTSANSSLQQLTQGEFLLLDHSSPGATPGFRTPAGYPKPTGLSWSDRSSLKSTAPLHLR 182

  Fly   227 EHAEAKTTT-------TSTSTTQAPLPILRARFGGFPWATTQAPSPPTTSSTSSTTTTSTTTTTT 284
            :|.:|..|:       :.:.:.|.|..:..|..     .....|:||||.:.:.....|.|
Mouse   183 KHIKADETSMQLPEEKSHSQSLQLPSELKMAHL-----LPKTVPTPPTTVAVAPLRNVSAT---- 238

  Fly   285 TTSTTTTPSPRKQPKHIQVTGGLKPELLPADQLRNYIKDVYIRMPLAVIVDPSSASLEQAKRLYI 349
                                  |||||                  |...:..::.:|:|
Mouse   239 ----------------------LKPEL------------------LLTSISVTAKTLKQ------ 257

  Fly   350 DALQDKNIDIKIVLVTLNAAGAPSAFSFNNTREFIAGLNST-KEHEGGNSFVGVLHAAELVPYDS 413
               ::......:..||....|.|.:.||.......|.|.:| :.|....   |:|   |.:|:..
Mouse   258 ---KEATTASPVTTVTSKLPGVPGSTSFTPVVTHQAALTNTFQAHTDSK---GIL---ETMPFQG 313

  Fly   414 AVFISTAVIPPHTELVQDAAITLLKKRIRLFLLWYGERSGSE----NET---EDAVGGILGEVAI 471
            .   ||....|.                      :|:.|.||    |:|   ||....: |..::
Mouse   314 G---STLTSDPR----------------------HGKSSTSESSITNKTASWEDRRVSV-GSASL 352

  Fly   472 RSGGEIIHIVSTE 484
            ..|.:..|.:|.|
Mouse   353 NKGPKSQHGLSFE 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43394	NP_001245938.1	None
Mansc1	NP_080621.1	MANEC	23..116	CDD:129004	19/117 (16%)
		PHA03255	234..394	CDD:165513	40/217 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..339		9/52 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR16021
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100