Protein Alignment Bsg and ROBO4

DIOPT Version :10

• Sequence 1: NP_723346.2
• Gene: Bsg / 318841
• FlyBaseID: FBgn0261822
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: NP_061928.4
• Gene: ROBO4 / 54538
• HGNCID: 17985
• Length: 1007
• Species: Homo sapiens
• Alignment Length: 303
• Identity: 61/303 - (20%)
• Similarity: 104/303 - (34%)
• Gaps: 85/303 - (28%)

  Fly    99 SRTASTPASVSDEDRLSPEIAQKAPKIVGSCNSDDLRPVQCHLETKELWDK-FNELGTEMIITKT 162
            ||.|::.|..|    |:||..:|....:..|..|.|:       ||:.::| ..||      .:|
Human   171 SREANSKADPS----LNPEQLKKLQDKIEKCKQDVLK-------TKDKYEKSLKEL------DQT 218

  Fly   163 GRRMFPTVRVSFSGPMRHQTAADRY--AVLLDI---IPLDN-RRYRYAYH------RSA------ 209
            ..:....:...|....:.:....|:  .|||::   :.|.| ..|:..|.      ::|
Human   219 TPQYMENMEQVFEQCQQFEEKRLRFFREVLLEVQKHLDLSNVASYKTIYRELEQSIKAADAVEDL 283

  Fly   210 -WLVAGKADPPPPARLYSHPDTPLGPDALRRQVISFEK------IKLT--NNEMDKTGQIVLNSM 265
             |..|...    |....:.|........|.|.:...||      :.||  |...|::||....|:
Human   284 RWFRANHG----PGMAMNWPQFEEWSADLNRTLSRREKKKAVDGVTLTGINQTGDQSGQNKPGSV 344

  Fly   266 HRYQPRIHLVRIGPNQSVPT---------------SPAELQELDHKTFVFPETIFTAVTAYQNQ- 314
            ..|:         ..|:.||               :..:....|..|....|....|:..|:.|
Human   345 SSYE---------KTQTYPTDWSDDESNNPFSSTDANGDSNPFDEDTTSGTEVRVRALYDYEGQE 400

  Fly   315 ----------LITKLK-IDSNPFAKGFRDSSRLNDFDRDPMES 346
                      .:||:: .|...:.||..||.::..:..:.:|:
Human   401 HDELSFKAGDELTKIEDEDEQGWCKGRLDSGQVGLYPANYVEA 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bsg	NP_723346.2	Ig	423..481	CDD:472250
		Ig strand B	423..426	CDD:409353
		Ig strand C	436..440	CDD:409353
		Ig strand E	463..467	CDD:409353
		Ig strand F	477..481	CDD:409353
		Ig_3	495..573	CDD:464046
ROBO4	NP_061928.4	Ig	32..133	CDD:472250
		Ig strand B	49..53	CDD:409353
		Ig strand C	62..66	CDD:409353
		Ig strand F	111..116	CDD:409353
		Ig strand G	125..128	CDD:409353
		IgI_2_Robo	140..225	CDD:409389	18/70 (26%)
		Ig strand A	140..143	CDD:409389
		Ig strand A'	145..149	CDD:409389
		Ig strand B	153..160	CDD:409389
		Ig strand C	168..173	CDD:409389	1/1 (100%)
		Ig strand C'	175..178	CDD:409389	0/2 (0%)
		Ig strand D	183..187	CDD:409389	2/3 (67%)
		Ig strand E	190..196	CDD:409389	0/5 (0%)
		Ig strand F	203..211	CDD:409389	2/14 (14%)
		Ig strand G	214..225	CDD:409389	3/16 (19%)
		fn3	350..432	CDD:394996	16/81 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	531..551
		PHA03247	<567..876	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	713..793
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	806..826
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	971..1007