DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bsg and NPTN

DIOPT Version :9

Sequence 1:	NP_723346.2	Gene:	Bsg / 318841	FlyBaseID:	FBgn0261822	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_036560.1	Gene:	NPTN / 27020	HGNCID:	17867	Length:	398	Species:	Homo sapiens

Alignment Length:	243	Identity:	74/243 - (30%)
Similarity:	108/243 - (44%)	Gaps:	39/243 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   421 PLVLSCNVKDGTPG-GVLIWKKNGTAVTDVPSLRGRFKLIADENKFIIDKTDTNDDGKYSCEFDG 484
            |:.|.||:...:.. ....|.|||..::..       :..|...::.|:|....|.|:|.|.:..
Human   165 PVTLQCNLTSSSHTLTYSYWTKNGVELSAT-------RKNASNMEYRINKPRAEDSGEYHCVYHF 222

  Fly   485 VS-----KEIEVIARVVVRVPSNTA------VVEGEKMSVTCSVVG-TKPELTWTFAN----VTL 533
            ||     ..|||.|     .|..|.      ..||:..::.|..|| ..|:..|....    :.:
Human   223 VSAPKANATIEVKA-----APDITGHKRSENKNEGQDATMYCKSVGYPHPDWIWRKKENGMPMDI 282

  Fly   534 TNATDRFILKPDDNGVPNAILTLDNVTLDDRGEYKCIGRNAANVYGGNTTTPASDVTTVRVKGKF 598
            .|.:.||.:...:|.....|:.| .:| :|.|||:|   ||.|..|.     ||.||.:||:...
Human   283 VNTSGRFFIINKENYTELNIVNL-QIT-EDPGEYEC---NATNAIGS-----ASVVTVLRVRSHL 337

  Fly   599 AALWPFLGICAEVLILCIIILIYEKRRNKSELEESDTDPQEQKKKRRN 646
            |.|||||||.||::||.:||::||||:...|:.:.|......|....|
Human   338 APLWPFLGILAEIIILVVIIVVYEKRKRPDEVPDDDEPAGPMKTNSTN 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bsg	NP_723346.2	IG_like	420..497	CDD:214653	21/81 (26%)
		Ig	423..497	CDD:299845	20/79 (25%)
		IG_like	500..583	CDD:214653	25/93 (27%)
		Ig	512..575	CDD:143165	18/67 (27%)
NPTN	NP_036560.1	Ig	31..146	CDD:416386
		Ig strand A	32..36	CDD:409353
		Ig strand A'	37..43	CDD:409353
		Ig strand B	46..55	CDD:409353
		Ig strand C	60..68	CDD:409353
		Ig strand C'	73..77	CDD:409353
		Ig strand D	87..93	CDD:409353
		Ig strand E	96..105	CDD:409353
		Ig strand F	112..120	CDD:409353
		Ig strand G	136..146	CDD:409353
		Narpin, mediates binding with FGFR1 and has antidepressant-like activity. /evidence=ECO:0000250	149..161
		Ig	168..219	CDD:416386	13/57 (23%)
		Ig strand C	180..185	CDD:409353	0/4 (0%)
		Ig strand E	201..205	CDD:409353	0/3 (0%)
		Ig strand F	215..219	CDD:409353	1/3 (33%)
		Ig_3	238..320	CDD:404760	23/86 (27%)
		Ig strand B	255..262	CDD:409353	1/6 (17%)
		Ig strand C	268..275	CDD:409353	1/6 (17%)
		Ig strand C'	278..280	CDD:409353	0/1 (0%)
		Ig strand D	291..295	CDD:409353	0/3 (0%)
		Ig strand E	297..302	CDD:409353	0/4 (0%)
		Ig strand F	312..320	CDD:409353	6/10 (60%)
		Ig strand G	323..333	CDD:409353	5/14 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	365..398		4/21 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157443
Domainoid	1	1.000	60	1.000	Domainoid score	I10589
eggNOG	1	0.900	-	-		E1_28H7W
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5184
SonicParanoid	1	1.000	-	-		X1696
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.730