DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bsg and LRIG1

DIOPT Version :9

Sequence 1:	NP_723346.2	Gene:	Bsg / 318841	FlyBaseID:	FBgn0261822	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_056356.2	Gene:	LRIG1 / 26018	HGNCID:	17360	Length:	1093	Species:	Homo sapiens

Alignment Length:	696	Identity:	143/696 - (20%)
Similarity:	221/696 - (31%)	Gaps:	245/696 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 VNLGQPFSITCIIPITDQIHWLKNG-EPITRHNLRHGRDDHAYVLS---------ESAIEGEKHK 102
            ||.|..:.:|.:    .|:|...|. ..|.|......:..|..|||         ||..|.....
Human   274 VNSGSLYGLTAL----HQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLS 334

  Fly   103 I--EAHLSVRHALKVHEGRYQCNRRRGSYILHVRD-PKGVGAGAGEPTESGYQTIDELTP----- 159
            :  .:|.|:.|   :.||.:     :|...|.|.| .....:|..|.|...:..:|.|:.
Human   335 VLRLSHNSISH---IAEGAF-----KGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFG 391

  Fly   160 NSADDFFTRAW--LEQQQQQQQLPHQSHKLHKSHLGYGNASLSGSQ------------------- 203
            |.......||:  ||..:               ||..|..::...|
Human   392 NKIKSVAKRAFSGLEGLE---------------HLNLGGNAIRSVQFDAFVKMKNLKELHISSDS 441

  Fly   204 -----------PW---------------HPSAGGGGIHRVYSATP-----PDFPPPRLNLLEQTV 237
                       ||               ||.:..|  ..::|..|     .||..|      |.:
Human   442 FLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKG--QSIFSVPPESFVCDDFLKP------QII 498

  Fly   238 APPEPPTILYNPNPTHPTASATATETSVL----------LTTAHH----HAHHQQQLQQQSQHTL 288
            ..|| .|:.........|.||.::.:|.:          ||.|..    |.|.|.....:....|
Human   499 TQPE-TTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTTIL 562

  Fly   289 NAFQLPLPPRPNPGQNERYQTYAPHYVPPVVVSGAGAGAGADPGAGASGEQTTISAATSTRAMMG 353
            :..|:..      |...|||....::.
Human   563 HLRQVTF------GHEGRYQCVITNHF-------------------------------------- 583

  Fly   354 GGGGVAGAGFSAGASGPMLGAGGHMLMGGQGHQVHLQHQTLLPVKMDKLVPNYDNAEHQMKFYDI 418
                  |:.:|                          |:..|.|   .::|::....|.:   .|
Human   584 ------GSTYS--------------------------HKARLTV---NVLPSFTKTPHDI---TI 610

  Fly   419 RSPLV--LSCNVKDGTPGGVLIWKKNGTAVTDVPSLR-GRFKLIADENKFIIDKTDTNDDGKYSC 480
            |:..:  |.| ...|.|...:.|:|:|.  ||.|:.| .|..::.|::.|.|.....:|.|.|||
Human   611 RTTTMARLEC-AATGHPNPQIAWQKDGG--TDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSC 672

  Fly   481 EFDGVSKEIEVIARVVVR------VPSNTAVVE-GEKMSVTCSVVGT-KPELTWTFANVTLTNAT 537
            .....:..|...|.:.|.      ||....||. ||.:::.|...|. .|.:|| |......:.|
Human   673 TAQNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITW-FKGDRPLSLT 736

  Fly   538 DRFILKPDDNGVPNAILTLDNVTLDDRGEYKCIGRNAANVYGGN------TTTPAS----DVTTV 592
            :|..|.||     |.:|.:.||..:|.|.|.|   ..:|..|..      :..||:    |.|||
Human   737 ERHHLTPD-----NQLLVVQNVVAEDAGRYTC---EMSNTLGTERAHSQLSVLPAAGCRKDGTTV 793

  Fly   593 RVKGKFAALWPFLGICAEVLI--LCIIILIYEKRRNKSELEESDTD 636
               |.|.     :.:.:.:::  |..:.:||:.|:...|...::||
Human   794 ---GIFT-----IAVVSSIVLTSLVWVCIIYQTRKKSEEYSVTNTD 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bsg	NP_723346.2	IG_like	420..497	CDD:214653	22/79 (28%)
		Ig	423..497	CDD:299845	22/76 (29%)
		IG_like	500..583	CDD:214653	26/90 (29%)
		Ig	512..575	CDD:143165	19/63 (30%)
LRIG1	NP_056356.2	leucine-rich repeat	51..69	CDD:275380
		LRR_RI	<53..176	CDD:238064
		leucine-rich repeat	70..93	CDD:275380
		LRR_8	71..127	CDD:290566
		leucine-rich repeat	117..140	CDD:275378
		LRR_RI	131..416	CDD:238064	38/168 (23%)
		LRR_8	140..223	CDD:290566
		leucine-rich repeat	141..164	CDD:275380
		leucine-rich repeat	165..197	CDD:275380
		LRR_8	211..271	CDD:290566
		leucine-rich repeat	213..236	CDD:275380
		leucine-rich repeat	237..260	CDD:275380
		LRR_8	259..319	CDD:290566	13/48 (27%)
		leucine-rich repeat	261..284	CDD:275380	3/9 (33%)
		leucine-rich repeat	285..308	CDD:275380	5/26 (19%)
		LRR_8	308..367	CDD:290566	16/66 (24%)
		leucine-rich repeat	309..332	CDD:275380	7/22 (32%)
		leucine-rich repeat	333..356	CDD:275380	6/30 (20%)
		leucine-rich repeat	357..381	CDD:275380	6/23 (26%)
		LRR_8	383..442	CDD:290566	10/73 (14%)
		leucine-rich repeat	384..405	CDD:275380	4/20 (20%)
		leucine-rich repeat	408..431	CDD:275380	4/37 (11%)
		LRRCT	442..490	CDD:214507	7/49 (14%)
		I-set	495..595	CDD:254352	25/182 (14%)
		Ig	512..586	CDD:143165	17/123 (14%)
		I-set	599..689	CDD:254352	26/95 (27%)
		Ig_1	616..690	CDD:143240	22/76 (29%)
		I-set	693..780	CDD:254352	27/95 (28%)
		IGc2	707..770	CDD:197706	22/71 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910