DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bsg and OBSL1

DIOPT Version :9

Sequence 1:	NP_723346.2	Gene:	Bsg / 318841	FlyBaseID:	FBgn0261822	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	XP_011509159.1	Gene:	OBSL1 / 23363	HGNCID:	29092	Length:	1918	Species:	Homo sapiens

Alignment Length:	720	Identity:	133/720 - (18%)
Similarity:	210/720 - (29%)	Gaps:	241/720 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 VNLGQPFSITCII---PITDQIHWLKNGEPI--TRHNLRHGRDDHAYVLSESAIEGEKHKIEAHL 107
            ||.|:.....|.:   | ..:|.|...|.|:  .|..|.:...|..:|                |
Human   257 VNEGKHAKFRCYVMGKP-EPEIEWHWEGRPLLPDRRRLMYRDRDGGFV----------------L 304

  Fly   108 SVRHALKVHEGRYQCNRRR------GSYILHVRDPK--------GVGAGAGEPTESGYQTIDELT 158
            .|.:......|.|.|..|.      .:..|||::|:        .|     |..|.|...::...
Human   305 KVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDV-----EGREHGIAVLECKV 364

  Fly   159 PNSADDFFTRAWLEQQQ------QQQQLPHQS------HKLHKSHLGY----------------- 194
            |||.   ...||..:.|      :.:|:...:      |:|.....|.
Human   365 PNSR---IPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRTVANVTV 426

  Fly   195 --------------------------------GNASLSGSQ-PWHPSAGGGGIHRVY--SATPPD 224
                                            |..|..|.: |....:..|.:|.:.  ..|..|
Human   427 KGPILKRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPVICQSSSGHMHALVLPGVTRED 491

  Fly   225 FPPPRLNLLEQTV-----------APPEPP-----------TILYNPNPTHPTASATATETSVLL 267
            ......:|.....           :||.||           |:|....|..|     |.||..:.
Human   492 AGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEP-----APETPFIY 551

  Fly   268 TTAHHHAHHQQQLQQQSQHTLNAFQLPLPPRPNPGQNE-RYQTYAPHYVPPVVVSGAGAG----- 326
            .........:..:|..|.....|.::|....|:.|... |..|.:.|...|.||....|.
Human   552 RLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTA 616

  Fly   327 ---AGADPGAGASGEQTTISAATSTRAMMGGGGGVAGAGFSAGASGPMLGAGGHMLMGGQGHQVH 388
               ||.:......||....|...||.        :.|..|..|.........|.:..|...:::.
Human   617 RLVAGLEDVQVYDGEDAVFSLDLSTI--------IQGTWFLNGEELKSNEPEGQVEPGALRYRIE 673

  Fly   389 ---LQHQTLLPVKMDKLVPNYDNAEHQMKFYDIRSPLVLSC-NVKDG-------TPGGVL----- 437
               |||:.:|               |.:|..|..:.:..|| .|:|.       :|..:|
Human   674 QKGLQHRLIL---------------HAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDR 723

  Fly   438 ------------------------IWKKNGTAVTD----VPSLRGRFKLIADENKFIIDKTDTND 474
                                    .|.|:|..|.:    |..:.||      :::.|:.:....|
Human   724 VSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGR------KHRLILPEAKVQD 782

  Fly   475 DGKYSCEFDGVSKEIEVIARVVVRVPSNTAV----------VEGEKMSVTCSVVGTKPELTWTFA 529
            .|::.|..:|||    ....|.|:.|....|          :..|.:.:.|.|......:.| :.
Human   783 SGEFECRTEGVS----AFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDAPVRW-YK 842

  Fly   530 NVTLTNATDRFILKPDDNGVPNAILTLDNVTLDDRGEYKCIGRNAANVYGGNTTTPASDVTT--V 592
            :......:|..:|   :|..|:..|.|......|.||::|:..:....:    |...:||::  |
Human   843 DGQEVEESDFVVL---ENEGPHRRLVLPATQPSDGGEFQCVAGDECAYF----TVTITDVSSWIV 900

  Fly   593 RVKGK 597
            ...||
Human   901 YPSGK 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bsg	NP_723346.2	IG_like	420..497	CDD:214653	21/117 (18%)
		Ig	423..497	CDD:299845	21/114 (18%)
		IG_like	500..583	CDD:214653	16/92 (17%)
		Ig	512..575	CDD:143165	13/62 (21%)
OBSL1	XP_011509159.1	IG_like	18..101	CDD:214653
		IGc2	25..88	CDD:197706
		IG	134..226	CDD:214652
		IGc2	142..216	CDD:197706
		IG	252..336	CDD:214652	20/95 (21%)
		Ig	252..336	CDD:299845	20/95 (21%)
		I-set	342..426	CDD:254352	14/91 (15%)
		Ig	358..421	CDD:143165	10/65 (15%)
		IG_like	435..510	CDD:214653	9/74 (12%)
		FN3	518..602	CDD:238020	19/88 (22%)
		IG	725..802	CDD:214652	15/86 (17%)
		Ig	734..802	CDD:143165	15/77 (19%)
		Ig	825..893	CDD:143165	14/75 (19%)
		Ig	916..984	CDD:143165
		IG	1005..1074	CDD:214652
		Ig	1007..1075	CDD:143165
		IG_like	1097..1154	CDD:214653
		IGc2	1099..1159	CDD:197706
		Ig_Semaphorin_C	1178..1267	CDD:143180
		IG	1180..1262	CDD:214652
		IG	1282..1343	CDD:214652
		IGc2	1283..1341	CDD:197706
		I-set	1361..1444	CDD:254352
		ig	1364..1430	CDD:278476
		IG_like	1456..1535	CDD:214653
		Ig	1481..1536	CDD:143165
		I-set	1541..1624	CDD:254352
		I-set	1631..1714	CDD:254352
		Ig	1635..1724	CDD:299845
		I-set	1725..1803	CDD:254352
		Ig	1814..1893	CDD:299845
		IG_like	1815..1893	CDD:214653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910