DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bsg and dscam

DIOPT Version :9

Sequence 1:	NP_723346.2	Gene:	Bsg / 318841	FlyBaseID:	FBgn0261822	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	XP_031751619.1	Gene:	dscam / 100216449	XenbaseID:	XB-GENE-921689	Length:	2039	Species:	Xenopus tropicalis

Alignment Length:	713	Identity:	141/713 - (19%)
Similarity:	239/713 - (33%)	Gaps:	191/713 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 TIYYGDPV-VNL---------GQPFSITCIIPITD--QIHWLKNGEPITR-HNLRHGRDDHAYVL 91
            ::|...|: ||:         |...|:.|.:..||  .:.|.:|||.|.. :|:|
Frog   307 SLYVKQPLKVNISPRKVKSSVGSQISLACSVTGTDDPDLSWYRNGEIINAGNNVR---------- 361

  Fly    92 SESAIEGEKHKIEAHLSVRHALKVHEGRYQCNRRRG--------SYILHVRDPKGVGA------G 142
                |.|...:.   |.:....|...|.|||..||.        ..:|....||.:.|      .
Frog   362 ----ITGVNRET---LIMDGMAKSDSGAYQCFVRREKMSAQDYVQVVLEDGTPKIISAFSEKVVS 419

  Fly   143 AGEPTESGYQTIDELTPNSADDFFTRAWLEQQQQQQQLPHQSHKLHKSHLGYGNA----SLSGSQ 203
            .|||............|       |..|  .......:.:.:|::.:.....||.    :::.:|
Frog   420 PGEPVSLMCNVKGTPLP-------TITW--TLDDDPIIKNGNHRISQLITSEGNVVSYLNITNTQ 475

  Fly   204 PWHPSAGGGGIHR----------VYSATPPDFPPPRLNLLEQTVAPPEPPTILYNPNPTHPTASA 258
                 ...||::|          :|.|......|..:..::...|.....|.::.....:|..|.
Frog   476 -----VRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSI 535

  Fly   259 TATETSVLLTTAHHHAHHQ----------QQLQQQSQHTLNAFQLP-------------LPPRPN 300
            ...:.|.||...|.....:          |:...:.::..|....|             :||...
Frog   536 KWYKNSNLLPFNHRQVAFENNGTLKLSDVQKDVDEGEYMCNVLVQPQLSTSQSVHVTVKVPPFIQ 600

  Fly   301 PGQNERYQTYAPHYVPPVVVSG----------AGAGAGADPGAGASGEQTTISAATSTRAMMGGG 355
            |.:::|:......::|.|||||          .|....|..|........|.|...|..::|..|
Frog   601 PFESQRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPASLGVTIDNIDFTSSLRISNLSLMHNG 665

  Fly   356 GGVAGAGFSAGASGPMLGAGGHMLMGGQGHQVHLQHQTLLPVKMDKLVPNY-DNAEHQMKFYDIR 419
            .....|...|.|                     ::||:.|.|::.   |.: .....|...|.
Frog   666 NYTCIARNDAAA---------------------VEHQSQLIVRVP---PRFVVQPTDQDGIYG-- 704

  Fly   420 SPLVLSCNVKDGTPGGVLIWK-KNGTAVTDVP--SLRGRFKLIADENKFIIDKTDTNDDGKYSCE 481
            ..::|:|:. :|.|...::|| ..|..|....  :|.||.:|:.: ...:|......|.|.|.|:
Frog   705 KAVILNCSA-EGYPVPTIVWKYSKGAGVPQFQPIALNGRIQLLTN-GSLLIKHVLEEDSGYYLCK 767

  Fly   482 FDG-----VSKEIEVIARV---VVRVPSNTAVVEGEKMSVTCSVVGTKPELTWTFANVTLTNATD 538
            ...     |||.:.:..::   :...|:.|...:|:|..::|:..|.||.:........:.|..:
Frog   768 VSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRMINVPE 832

  Fly   539 --RFILKPDDNG--VPNAILTLDNVTLDDRGEYKCIGRNAANVYGGN-----------TTTPASD 588
              |:::...:.|  |.:.:..|..|. :|.|.:.|   :|.|.:|.:           ...|..:
Frog   833 MSRYLVSTKEVGEEVISTLQILPTVR-EDSGFFSC---HAINSFGEDRGIIQLTVQEPPDPPEIE 893

  Fly   589 VTTVRVKGKFAALW--------PFLGICAEVLILCIIILIYEKRRNKSELEES-----DTDPQ 638
            :..||.: ..|..|        |..|...|    |         :|||:..:|     |..||
Frog   894 IREVRAR-SIALRWTMGFDGNSPITGYDIE----C---------KNKSDSWDSVQRTKDVSPQ 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bsg	NP_723346.2	IG_like	420..497	CDD:214653	20/87 (23%)
		Ig	423..497	CDD:299845	20/84 (24%)
		IG_like	500..583	CDD:214653	20/97 (21%)
		Ig	512..575	CDD:143165	13/66 (20%)
dscam	XP_031751619.1	Ig	26..121	CDD:416386
		Ig strand A'	33..37	CDD:409353
		Ig strand B	40..49	CDD:409353
		Ig strand C	55..61	CDD:409353
		Ig strand C'	63..66	CDD:409353
		Ig strand D	72..75	CDD:409353
		Ig strand E	80..85	CDD:409353
		Ig strand F	98..106	CDD:409353
		Ig strand G	109..121	CDD:409353
		Ig	124..217	CDD:416386
		Ig strand A'	127..136	CDD:409353
		Ig strand B	140..147	CDD:409353
		Ig strand C	157..162	CDD:409353
		Ig strand C'	164..167	CDD:409353
		Ig strand D	172..176	CDD:409353
		Ig strand E	179..185	CDD:409353
		Ig strand F	193..201	CDD:409353
		Ig strand G	205..217	CDD:409353
		Ig strand A	225..228	CDD:409353
		Ig strand A'	234..237	CDD:409353
		IG_like	236..310	CDD:214653	0/2 (0%)
		Ig strand B	242..249	CDD:409353
		Ig strand C	255..260	CDD:409353
		Ig strand C'	262..264	CDD:409353
		Ig strand D	270..274	CDD:409353
		Ig strand E	276..280	CDD:409353
		Ig strand F	289..297	CDD:409353
		Ig strand G	300..310	CDD:409353	0/2 (0%)
		Ig	313..395	CDD:416386	25/98 (26%)
		Ig strand A	314..319	CDD:409353	2/4 (50%)
		Ig strand A'	322..326	CDD:409353	0/3 (0%)
		Ig strand B	329..339	CDD:409353	2/9 (22%)
		Ig strand C	344..350	CDD:409353	1/5 (20%)
		Ig strand C'	351..354	CDD:409353	2/2 (100%)
		Ig strand E	368..374	CDD:409353	1/8 (13%)
		Ig strand F	381..389	CDD:409353	4/7 (57%)
		Ig	406..501	CDD:416386	18/108 (17%)
		Ig strand A	406..409	CDD:409353	1/2 (50%)
		Ig strand A'	415..419	CDD:409353	0/3 (0%)
		Ig strand B	422..431	CDD:409353	2/8 (25%)
		Ig strand C	436..442	CDD:409353	3/14 (21%)
		Ig strand C'	444..447	CDD:409353	0/2 (0%)
		Ig strand D	452..460	CDD:409353	1/7 (14%)
		Ig strand E	464..473	CDD:409353	1/8 (13%)
		Ig strand F	480..488	CDD:409353	2/7 (29%)
		Ig strand G	491..501	CDD:409353	2/9 (22%)
		Ig	504..593	CDD:416386	12/88 (14%)
		Ig strand A	505..507	CDD:409353	0/1 (0%)
		Ig strand A'	512..516	CDD:409353	0/3 (0%)
		Ig strand B	519..526	CDD:409353	1/6 (17%)
		Ig strand C	533..539	CDD:409353	1/5 (20%)
		Ig strand C'	540..542	CDD:409353	0/1 (0%)
		Ig strand D	549..553	CDD:409353	0/3 (0%)
		Ig strand E	557..563	CDD:409353	0/5 (0%)
		Ig strand F	571..579	CDD:409353	1/7 (14%)
		Ig strand G	583..593	CDD:409353	0/9 (0%)
		Ig	596..686	CDD:416386	24/110 (22%)
		Ig strand A	597..599	CDD:409353	1/1 (100%)
		Ig strand A'	604..608	CDD:409353	1/3 (33%)
		Ig strand B	611..620	CDD:409353	2/8 (25%)
		Ig strand C	625..632	CDD:409353	0/6 (0%)
		Ig strand C'	634..636	CDD:409353	1/1 (100%)
		Ig strand D	643..648	CDD:409353	0/4 (0%)
		Ig strand E	651..658	CDD:409353	2/6 (33%)
Ig strand F	665..673	CDD:409353	2/7 (29%)
Ig strand G	676..685	CDD:409353	3/29 (10%)
Ig_DSCAM	689..784	CDD:409397	23/101 (23%)
Ig strand B	707..711	CDD:409397	1/3 (33%)
Ig strand C	720..724	CDD:409397	0/3 (0%)
Ig strand E	749..753	CDD:409397	0/3 (0%)
Ig strand F	763..768	CDD:409397	2/4 (50%)
Ig strand G	777..780	CDD:409397	2/2 (100%)
Ig_DSCAM	785..885	CDD:409398	20/103 (19%)
Ig strand B	805..809	CDD:409398	0/3 (0%)
Ig strand C	818..822	CDD:409398	0/3 (0%)
Ig strand E	849..853	CDD:409398	0/3 (0%)
Ig strand F	863..868	CDD:409398	1/7 (14%)
Ig strand G	876..879	CDD:409398	0/2 (0%)
FN3	886..980	CDD:238020	16/71 (23%)
FN3	987..1084	CDD:238020
FN3	1093..1185	CDD:238020
FN3	1190..1279	CDD:238020
Ig_3	<1303..1364	CDD:404760
Ig strand B	1304..1311	CDD:409353
Ig strand C	1317..1322	CDD:409353
Ig strand C'	1327..1333	CDD:409353
Ig strand D	1337..1341	CDD:409353
Ig strand E	1343..1347	CDD:409353
Ig strand F	1356..1364	CDD:409353
Ig strand G	1367..1377	CDD:409353
FN3	1381..1471	CDD:238020
FN3	1497..1568	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910