DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33061 and TMEM38A

DIOPT Version :9

Sequence 1:	NP_001097620.1	Gene:	CG33061 / 318838	FlyBaseID:	FBgn0053061	Length:	282	Species:	Drosophila melanogaster
Sequence 2:	NP_076979.1	Gene:	TMEM38A / 79041	HGNCID:	28462	Length:	299	Species:	Homo sapiens

Alignment Length:	228	Identity:	61/228 - (26%)
Similarity:	105/228 - (46%)	Gaps:	14/228 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 VVSAGSFRLKGGGNKVLEWQPFVLWLANLLLNYAGDILGNLLLGSLPLEPLCNTADVMLSSLIWY 97
            :||....:.:.|..::....|...||..:|..:...||.:||||...::...|.:.::|:|.:||
Human    31 IVSILYLKYEPGAVELSRRHPIASWLCAMLHCFGSYILADLLLGEPLIDYFSNNSSILLASAVWY 95

  Fly    98 CIFYCPFDLAHAVTSTLAFRILATAMSTISQVQLIDRGVHLAAQVYGNAPIPMLVVGTVMGSGAE 162
            .||:||.||.:.....|..:::..||..:.:|:.|..|:|.|...|.:....|:..|.|.|||..
Human    96 LIFFCPLDLFYKCVCFLPVKLIFVAMKEVVRVRKIAVGIHHAHHHYHHGWFVMIATGWVKGSGVA 160

  Fly   163 VLKPVASLLINRCQHNQMAYLKLSNTSKVALFISLLFMLE------VYKSPIIMGINRHQLMVYI 221
            ::.....||....:......|.:|..:|.:|:.::||.|:      |.|:.:|        .::.
Human   161 LMSNFEQLLRGVWKPETNEILHMSFPTKASLYGAILFTLQQTRWLPVSKASLI--------FIFT 217

  Fly   222 LVMTTAFKFLSLCYRTDHIIWLLEQHIRYTLFG 254
            |.|.:...||:..:........||.:|...|||
Human   218 LFMVSCKVFLTATHSHSSPFDALEGYICPVLFG 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33061	NP_001097620.1	TRIC	45..231	CDD:282982	50/191 (26%)
TMEM38A	NP_076979.1	TRIC	43..225	CDD:310067	50/189 (26%)
TMEM38A	NP_076979.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..299
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3944
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4641
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1319985at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12454
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.830