Protein Alignment lz and RUNX1

DIOPT Version :9

• Sequence 1: NP_511099.2
• Gene: lz / 31883
• FlyBaseID: FBgn0002576
• Length: 826
• Species: Drosophila melanogaster
• Sequence 2: NP_001745.2
• Gene: RUNX1 / 861
• HGNCID: 10471
• Length: 480
• Species: Homo sapiens
• Alignment Length: 563
• Identity: 181/563 - (32%)
• Similarity: 227/563 - (40%)
• Gaps: 184/563 - (32%)

  Fly   282 EHPGELVRTSNPYFLCSALPAHWRSNKTLPMAFKVVALAEVGDGTYVTIRAGNDENCCAELRNFT 346
            :||||||||.:|.||||.||.|||.|||||:|||||||.:|.|||.||:.||||||..|||||.|
Human    84 DHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNAT 148

  Fly   347 TQMKNDVAKFNDLRFVGRSGRGKSFTLTITVATSPPQVATYAKAIKVTVDGPREPRSKTSPTGGP 411
            ..|||.||:||||||||||||||||||||||.|:|||||||.:|||:|||||||||.
Human   149 AAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRR-------- 205

  Fly   412 HYRALGLGQRPYIDGFPSTKALHELESLRRSAKVAAVTTAAAAAATAASAANAVAAAAAAVAVTP 476
            |.:.|....:|....|  ::.|.|||.|||       |....:....|...|..|:...:.|..|
Human   206 HRQKLDDQTKPGSLSF--SERLSELEQLRR-------TAMRVSPHHPAPTPNPRASLNHSTAFNP 261

  Fly   477 TGGGGGVAAGGVAGGAGAGLVQQLSSNYSSPNSTINSDCQVYKPNAPHIQAAEMMGAGEWTNGSS 541
                                         .|.|.:....|: :|:.|            |:...|
Human   262 -----------------------------QPQSQMQDTRQI-QPSPP------------WSYDQS 284

  Fly   542 SSAAAYYHSHAHHPHAHHAHAHLQHQMALPPPPPPPAAAPVSVGVGGNGATMGMGMGVGVGMGMN 606
            ........|.:.||                       |.|:|.|......|:...:.       :
Human   285 YQYLGSIASPSVHP-----------------------ATPISPGRASGMTTLSAELS-------S 319

  Fly   607 HYGGGYDSANSLEAGQYAAHLPAVL-PEMHGHG-FATDPYQ-TAGYGGGNTGGGSASK------- 661
            ......|.....:..|:.| ||::. |.||..| |...|.. |:|.|.|.:..|||::
Human   320 RLSTAPDLTAFSDPRQFPA-LPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPP 383

  Fly   662 ----SELDYGGSYNQAWSNGYQNYQYGSCLATAQY---GPQAAPPPQPPPPPPVVLCPQLYSTVN 719
                |....||.: ||.|..|..| ||:...:.|:   |.:.:||...||
Human   384 PYPGSSQAQGGPF-QASSPSYHLY-YGASAGSYQFSMVGGERSPPRILPP--------------- 431

  Fly   720 QNQIHLHLHSSEKLEQYLGTATSADHLTIGSLTGSSRSSIEIGQDQYHQQVHHAQQQQQQQQQQQ 784
                                .|:|.       |||:..:..:
Human   432 --------------------CTNAS-------TGSALLNPSL----------------------- 446

  Fly   785 QVHHPQQQQ-VESAGEVGGSGAGGVESAREEDVGDLSQVWRPY 826
                |.|.. ||:.|....|......|||.|:.     |||||
Human   447 ----PNQSDVVEAEGSHSNSPTNMAPSARLEEA-----VWRPY 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lz	NP_511099.2	Runt	283..404	CDD:279225	95/120 (79%)
RUNX1	NP_001745.2	Runt	81..207	CDD:395684	95/130 (73%)
		RunxI	389..480	CDD:400691	33/166 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3982
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000993
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11950
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X738
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.870