DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lz and RUNX2

DIOPT Version :9

Sequence 1:	NP_511099.2	Gene:	lz / 31883	FlyBaseID:	FBgn0002576	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_001019801.3	Gene:	RUNX2 / 860	HGNCID:	10472	Length:	521	Species:	Homo sapiens

Alignment Length:	441	Identity:	143/441 - (32%)
Similarity:	197/441 - (44%)	Gaps:	137/441 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   282 EHPGELVRTSNPYFLCSALPAHWRSNKTLPMAFKVVALAEVGDGTYVTIRAGNDENCCAELRNFT 346
            :||.|||||.:|.||||.||:|||.|||||:|||||||.||.|||.||:.||||||..|||||.:
Human   108 DHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNAS 172

  Fly   347 TQMKNDVAKFNDLRFVGRSGRGKSFTLTITVATSPPQVATYAKAIKVTVDGPREPR--------- 402
            ..|||.||:||||||||||||||||||||||.|:|||||||.:|||||||||||||
Human   173 AVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRRHRQKLDDS 237

  Fly   403 ------SKTSPTGGPHYRALGLG-----QRPYIDGFPS---TKALHELESLRRS----------- 442
                  .:.|..|...:.::.:|     .||.::..||   .:...::...|::
Human   238 KPSLFSDRLSDLGRIPHPSMRVGVPPQNPRPSLNSAPSPFNPQGQSQITDPRQAQSSPPWSYDQS 302

  Fly   443 --AKVAAVTTAAAAAATAASAANAVAAAAAAVAVTPTGGGGGVAAGGVAGGAGAGLVQQLSSNYS 505
              :.::.:|:.:..:.|..|:..                           |.|...:..:....|
Human   303 YPSYLSQMTSPSIHSTTPLSSTR---------------------------GTGLPAITDVPRRIS 340

  Fly   506 SPNSTINSDCQVYKPNAPHIQAAEMMGAGE---------WTNGSSSSAAAYYHSHAHHPHAHHAH 561
            . :.|..||..:: |:.  :......||.|         :.:.||.:.:.:.:...|:|..
Human   341 D-DDTATSDFCLW-PST--LSKKSQAGASELGPFSDPRQFPSISSLTESRFSNPRMHYPAT---- 397

  Fly   562 AHLQHQMALPPPPPPPAAAPVSVGVGGNGATMGMGMGVGVGMGMNHYGGGYDSANSLEAGQYAAH 626
                  ....||                 .|.||.:|:              ||.:    .|..:
Human   398 ------FTYTPP-----------------VTSGMSLGM--------------SATT----HYHTY 421

  Fly   627 LPAVLPEMHGHGFA-TDPYQTAG----YGGGNTG--------GGSASKSEL 664
            ||   |...|...: :.|:||:.    |.|.::|        ||..|.|.:
Human   422 LP---PPYPGSSQSQSGPFQTSSTPYLYYGTSSGSYQFPMVPGGDRSPSRM 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lz	NP_511099.2	Runt	283..404	CDD:279225	95/135 (70%)
RUNX2	NP_001019801.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..59
		polyglutamine repeat	49..71
		polyalanine repeat	73..89
		Runt	109..230	CDD:307137	95/120 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	222..340		20/144 (14%)
		Required for interaction with FOXO1. /evidence=ECO:0000250	242..258		2/15 (13%)
		Herpes_BLLF1	<266..481	CDD:330317	45/283 (16%)
		Interaction with KAT6A. /evidence=ECO:0000250	336..439		26/154 (17%)
		Interaction with KAT6B. /evidence=ECO:0000269\|PubMed:11965546	374..468		26/141 (18%)
		RunxI	430..521	CDD:312115	10/40 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	460..521		4/10 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5786
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000993
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11950
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X738
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.960