DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lz and runx2

DIOPT Version :9

Sequence 1:	NP_511099.2	Gene:	lz / 31883	FlyBaseID:	FBgn0002576	Length:	826	Species:	Drosophila melanogaster
Sequence 2:	NP_001128588.1	Gene:	runx2 / 100189546	XenbaseID:	XB-GENE-482021	Length:	468	Species:	Xenopus tropicalis

Alignment Length:	333	Identity:	126/333 - (37%)
Similarity:	168/333 - (50%)	Gaps:	78/333 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   282 EHPGELVRTSNPYFLCSALPAHWRSNKTLPMAFKVVALAEVGDGTYVTIRAGNDENCCAELRNFT 346
            :||.|||||.:|..|||.||:|||.|||||:|||||||.||.||:.||:.||||||..||.||.:
Frog    82 DHPAELVRTDSPNLLCSVLPSHWRCNKTLPVAFKVVALGEVSDGSVVTVMAGNDENYSAEPRNAS 146

  Fly   347 TQMKNDVAKFNDLRFVGRSGRGKSFTLTITVATSPPQVATYAKAIKVTVDGPREPR--------S 403
            ..|||.||:||||||||||||||||||||||.|:|||||||.:|:|||||||||||        |
Frog   147 AVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAMKVTVDGPREPRRHRQKLDDS 211

  Fly   404 KTS-----PTGGPHYRALGLG-----QRPYIDGFP-STKALHELESLRRS-------------AK 444
            |.|     ..|...:.::.:|     .||.::..| :.:...::...|::             :.
Frog   212 KPSLFSERDLGRIPHPSMRMGVPPQSPRPSLNSSPFNPQGQSQIADPRQTQSSPPWSYDQSYPSY 276

  Fly   445 VAAVTTAAAAAATAASAANAVAAAAAAVAVTPTGGGGGVAAGGVAGGAGAGLVQQLS-SNYSSPN 508
            ::.:|:.:..:.|..|:..  .....|::..|....|....|..:.......:..|: |.:|:|.
Frog   277 LSQMTSPSIHSTTPLSSTR--GTGLPAISDVPRRLSGASELGPFSDPRQFTSISSLTESRFSNPR 339

  Fly   509 ----STINSDCQVYKPNAPHIQAAEMMGAGEWTNGSS--SSAAAYYHSHAHHPHAHHAHAHLQHQ 567
                :|.     .|.|..              |.|.|  .||..:||::
Frog   340 MHYPATF-----TYSPPV--------------TTGMSLGMSATTHYHTY---------------- 369

  Fly   568 MALPPPPP 575
              ||||.|
Frog   370 --LPPPYP 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lz	NP_511099.2	Runt	283..404	CDD:279225	91/128 (71%)
runx2	NP_001128588.1	Runt	83..204	CDD:279225	91/120 (76%)
runx2	NP_001128588.1	RunxI	378..468	CDD:285676
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000993
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11950
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X738
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010