DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpy and MGAM2

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:NP_001280555.1 Gene:MGAM2 / 93432 HGNCID:28101 Length:2515 Species:Homo sapiens


Alignment Length:1431 Identity:337/1431 - (23%)
Similarity:506/1431 - (35%) Gaps:362/1431 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly  6438 APPSEVRTTIRVE----ESTLPSRSTD---RTSPSESPETPTTLP-SDFITRPHSEKT--TESTR 6492
            |.|.|...:::.:    :...||...|   |...:|....|..:| .:...:..|.||  .||.:
Human  1358 ANPREPEKSLKFDGLWIDMNEPSNFVDGSVRGCSNEMLNNPPYMPYLESRDKGLSSKTLCMESQQ 1422

  Fly  6493 DVPTTRPFEASTPSSASSGNNCSISYFRNHYKCSNRFNRSADRTTPSESPETPTLPSDFTTRPHS 6557
            .:|.:.|.|                    ||...|.:..|                   .|||..
Human  1423 ILPDSSPVE--------------------HYNVHNLYGWS-------------------QTRPTY 1448

  Fly  6558 EQTTEST--RDVPTTRPFEASTPSPASLETTVPSVTSETTTNVPIGSTGGQVTGQTTAPPSEV-R 6619
            |...|.|  |.|..||             :|.||          .|..||...|..||...:: :
Human  1449 EAVQEVTGQRGVIITR-------------STFPS----------SGRWGGHRLGNNTAAWDQLGK 1490

  Fly  6620 TTIRVEESTLPSRSTDRTTPSESPETPTILPSDF-------------------TTRPHSDQTTES 6665
            :.|.:.|.:|          ...|.|...:...|                   .:|.|::..|..
Human  1491 SIIGMMEFSL----------FGIPYTGADICGFFGDAEYEMCVRWMQLGAFYPFSRNHNNIGTRR 1545

  Fly  6666 TRDVPTTRPFEASTPRPVTLETAVPSVTLETTTNVPIGST---GGQVTGQTTATPSEVRTTIRVE 6727
            ...|.....||..:.:  .|||..        |.:|...|   ...|.|.|...|          
Human  1546 QDPVAWNSTFEMLSRK--VLETRY--------TLLPYLYTLMHKAHVEGSTVVRP---------- 1590

  Fly  6728 ESTLPSRSTDRTT----------PS--ESPETPTTLPSDFTTRPHSDQTTESTRDVPTTRPFEAS 6780
              .|...:.||||          |:  .||...|:             |.|.:...|..|.::.|
Human  1591 --LLHEFTDDRTTWDIDRQFMLGPAILISPVLETS-------------TFEISAYFPRARWYDYS 1640

  Fly  6781 TPSPASLETTVPSVTSETTTNVPIGSTGGQV---TEQTTSSPSEVRTTIGLEESTLPSRST---- 6838
            | ..:|..|....:......::.:...||.:   .|...::.|..:..:||..: |....|    
Human  1641 T-GTSSTSTGQRKILKAPLDHINLHVRGGYILPWQEPAMNTHSSRQNFMGLIVA-LDDNGTAEGQ 1703

  Fly  6839 ---DRTSPSESPETPTTLPSDFITRPHSDQ-TTESTRDVPTTRPFEASTPSPASLETTVPSVTSE 6899
               |.....::.|......::||...:..| .|...:.:..:.|.:........:.|.|..| |.
Human  1704 VFWDDGQSIDTYENGNYFLANFIAAQNILQIQTIHNKYLSDSNPLKVGYIRIWGVNTYVTQV-SF 1767

  Fly  6900 TTTNVPIGSTGGQVTEQTTSSPSEVRTTIGLEESTLP-SRSTDRTSPSESPETPTTLPSDFITRP 6963
            |..|.....|..:      |.|.....||.|.:.|:. .:.|:.|.....|..||  |:...|.|
Human  1768 TYDNRQFMETNFK------SEPYNQILTIQLTDKTINLEKLTEVTWIDGGPVLPT--PTKTSTIP 1824

  Fly  6964 HSDQTTESTRDVPTTRPFEASTPSSASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEVRT 7028
            .|...:.||.:..::.    :..||||..||.     .||..|||         .|||.||   |
Human  1825 MSSHPSPSTTNATSSE----TITSSASANTTT-----GTTDTVPI---------TTTSFPS---T 1868

  Fly  7029 TIRVEESTLPSRSTDRTTPSESPETPTTLPSDFTTRPHSDQTTESSRDVP-TTQPFEASTPRPVT 7092
            |.....:|:|..::...|.:.:..|..|:|...|..|.|.....::..|| ||.||      |..
Human  1869 TSVTTNTTVPDTTSPFPTSTTNASTNATVPITTTPFPTSTIGVTTNATVPNTTAPF------PTN 1927

  Fly  7093 LQTAVLPVTSETTTNVPIGSTGGQVTEQT---TSSPSEVRTTIRVEESTLPSRSTDRTTPSESPE 7154
            ..||....|...||.....||.|..|..|   |::|....||.....:|:|..:|...|.:.|..
Human  1928 ASTASTNATVPITTTCFATSTIGVTTNATVPDTTAPFPTNTTTASTNATIPITTTPFATSTISVT 1992

  Fly  7155 TPTTLPSDFTTRPHSDQTTESSRD---VPTTQPFESSTPRPVTLETAVPPVTSETTTNVPIGSTG 7216
            |.||:|.  ||.|....||.:|.:   ||.|....:::...||..|.||..|:...|:....||.
Human  1993 TSTTVPD--TTAPFPTSTTSASTNATPVPITTTLFATSTIGVTTGTTVPDTTAPFPTSTTSTSTS 2055

  Fly  7217 GQVTEQTTPSPSEVRTTIRIEESTFPSRSTDRTTPSESPETPTTLPSDFTTRPHSDQTTESTRDV 7281
            ..|...|||||:..           ...:|..|.|:      ||:||     |.|..|..:...|
Human  2056 ATVPITTTPSPTNT-----------ADANTSNTVPN------TTMPS-----PTSSTTVSTIATV 2098

  Fly  7282 P--TTRPFESSTPRPVTLEIAVPPVTSET-TTNVAIGSTGGQVTEQTTSSPSEVRTTIRVEESTL 7343
            |  .|....|:....::..:.:...:|.| ||:|:..:|...::....::.:...|:..|...|.
Human  2099 PISVTPSLTSTADATISTTVLIATTSSLTGTTDVSTSTTINNISTPVQTNTTNASTSTNVANITA 2163

  Fly  7344 PSR-STDRTTPSESPETPTTLPS------DFTTRPHSDQTT---ESTRDVPTTRPFEASTPSPAS 7398
            .|. |||.|.|:.:... |.:||      |.|:...|..||   |||..:.||  ...:|.||.|
Human  2164 TSHTSTDDTVPNNTVPV-TAIPSLANTGVDTTSNSFSIMTTSFSESTNAMNTT--VIMATTSPTS 2225

  Fly  7399 LETTVPSVTLETTTSVPMGSTGGQVTGQTTAPPSEVRTTI---RVEESTLPSRSTDRTPPSESPE 7460
            .:....:.....|..:....:.|.:|..:.:    :.||.   .|...|.||.|||.|..|.:  
Human  2226 TDVASTNNDASMTNFLLATMSAGNITSNSIS----ITTTSFGNSVPFVTTPSPSTDATTTSNN-- 2284

  Fly  7461 TPTTLPSDFTTRPHSDQTTESSRDVPTTQPFESSTPRPVTLEIAVPPVTSETTTNVPIGSTGGQV 7525
                      |.|......::|..:||..  .:|.|..:|..:::.|.::..||:        ::
Human  2285 ----------TNPGMTTYYQTSPTIPTHT--LTSIPSSITSILSMFPTSNTFTTD--------KI 2329

  Fly  7526 TGQTTATPSEVRTTIGVEESTLPSRSTDRTTPSESPETPTTLPSDFTTRPHSDQTTESTRDVPTT 7590
            |..|  ||:...|.|   .:||              :|.:|:..|.|.      ||.||:|    
Human  2330 TNFT--TPTNANTII---FNTL--------------DTKSTMVIDATV------TTTSTKD---- 2365

  Fly  7591 RPFEASTPSPASLETTVPSVTLETTTNVPIGSTGGQVTGQTTATP-SEVRTTIGVEESTLPSRST 7654
                 :|.||   :|||.|:...||          .:|  ..||| |...||:.:..::|     
Human  2366 -----NTMSP---DTTVTSIDKFTT----------HIT--QFATPHSATTTTLALSHTSL----- 2405

  Fly  7655 DRTTPSESPETPTTLPS----DFTTRPHSDQTTESTRDVPTTRPFEASTPRPVT-LETAVP-SVT 7713
                      .||.|.:    |.|...:|...|.:|..:..:....||.....| |::..| .|.
Human  2406 ----------APTNLSNLGTMDITDADNSSSVTGNTTHISVSNLTTASVTITATGLDSQTPHMVI 2460

  Fly  7714 SETTTNVPIGSTVTSETTTNVPIGSTGGQVAGQTTAPPSEVRTTIRVEESTLPSRSADRTTPSES 7778
            :...|.:||.:|..:..|||:.      :.|..||.|.|.|.|:     :|.|:..|:....::.
Human  2461 NSVATYLPITATSATTDTTNIT------KYALNTTTPDSTVHTS-----ATAPTYIANAINATQV 2514

  Fly  7779 P 7779
            |
Human  2515 P 2515

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699
EGF_CA 212..247 CDD:238011
EGF_CA 255..>286 CDD:214542
EGF_CA 298..331 CDD:238011
EGF_CA 338..373 CDD:238011
EGF_CA 413..456 CDD:238011
EGF_CA 457..490 CDD:238011
EGF_CA 497..>529 CDD:214542
EGF_CA 580..>612 CDD:214542
EGF_3 676..702 CDD:289699
EGF_CA 1022..1056 CDD:214542
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572
DUF4696 4127..4678 CDD:292395
DUF4758 4275..4448 CDD:292572
DUF4758 4377..4574 CDD:292572
DUF4758 4581..4754 CDD:292572
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395 125/619 (20%)
DUF4758 6662..6839 CDD:292572 39/201 (19%)
DUF4758 6764..6941 CDD:292572 36/188 (19%)
DUF4758 6866..7045 CDD:292572 46/179 (26%)
DUF4758 6968..7179 CDD:292572 65/217 (30%)
DUF4696 7024..7569 CDD:292395 147/567 (26%)
DUF4758 7172..7383 CDD:292572 61/226 (27%)
DUF4696 7330..7964 CDD:292395 117/470 (25%)
DUF4758 7400..7587 CDD:292572 41/189 (22%)
DUF4758 7538..7707 CDD:292572 42/174 (24%)
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
MGAM2NP_001280555.1 Trefoil 43..87 CDD:278515
NtCtMGAM_N 104..214 CDD:293468
GH31_N 207..323 CDD:270212
Glyco_hydro_31 304..769 CDD:279404
GH31_MGAM_SI_GAA 323..680 CDD:269888
Trefoil 907..948 CDD:278515
NtCtMGAM_N 991..1083 CDD:293468
GH31_N 1076..1190 CDD:270212
Glyco_hydro_31 1171..1671 CDD:279404 82/420 (20%)
GH31_MGAM_SI_GAA 1190..1581 CDD:269888 59/304 (19%)
PHA03255 1819..>1965 CDD:165513 51/172 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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