DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpy and CD22

DIOPT Version :9

Sequence 1:NP_001260032.1 Gene:dpy / 318824 FlyBaseID:FBgn0053196 Length:22949 Species:Drosophila melanogaster
Sequence 2:NP_001762.2 Gene:CD22 / 933 HGNCID:1643 Length:847 Species:Homo sapiens


Alignment Length:682 Identity:141/682 - (20%)
Similarity:223/682 - (32%) Gaps:179/682 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly  4105 TTTNIPIGT--TRGQVTEQTTSSPSEKRTTIRVEESTLPSRSTDRTTPSESPETP----TILPSD 4163
            |:|::.|.:  ||.::......|...|..|.:::::.....|.| |.......||    .:.|||
Human   189 TSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSND-TVQLNVKHTPKLEIKVTPSD 252

  Fly  4164 STTRTYSDQTTESTRDVPTTRPFEASTPSPASLETTVP-----SVTLETTTNDPIGSTGGQVTEQ 4223
            :..|. .|..| .|.:|.::.| |.:|.|.....|::.     ::.|...|.|..|....||:..
Human   253 AIVRE-GDSVT-MTCEVSSSNP-EYTTVSWLKDGTSLKKQNTFTLNLREVTKDQSGKYCCQVSND 314

  Fly  4224 TTSSPSEVRTTIGLEESTLPSRSTDRTTPSESPE----------TPTTLPSDFITRPHSDQ---- 4274
            .....||   .:.|:....|..||.:...|.:.|          ....||::: |..|:.:    
Human   315 VGPGRSE---EVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNY-TWYHNGKEMQG 375

  Fly  4275 TTESTRDVPTTRPFEASTPSSASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRV 4339
            .||....:|...|:.|.|.|      .|....|.|....|    |.::..|  ..|.:|.|.|  
Human   376 RTEEKVHIPKILPWHAGTYS------CVAENILGTGQRGP----GAELDVQ--YPPKKVTTVI-- 426

  Fly  4340 EESTLPSRSADRTTPSESPETPTTLPSDFTTRPHS--EQTTESTRDVP------TTRPFEA---- 4392
             ::.:|.|..|..|.|.:..:.....:.:..:||.  |:.:.....:.      ||....|    
Human   427 -QNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVGWDNTTIACAACNSW 490

  Fly  4393 -STPSPASLETTVPSVTLETTTNVPIGS--TGGQVTGQ---TTSSPSEVRTTIRVEESTLPSRSA 4451
             |..||.:|........:......|:..  :|..|:.|   ::|.|.||: ....:...|..:.:
Human   491 CSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQ-FFWEKNGRLLGKES 554

  Fly  4452 DRTTPSESPETPTTLP---SDFITRPHSEKTTESTRDVPTTRPFEAS-TPSSASLETTVPSVTLE 4512
            .....|.|||...:..   ::.|.:..|:..|......|  |....| :|....:|....::|.|
Human   555 QLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAP--RRLRVSMSPGDQVMEGKSATLTCE 617

  Fly  4513 TTTNVPIG--------------------------STGGQVTEQTTSSPSEVRTTIRVEESTLPSR 4551
            :..|.|:.                          ...|....|.|:|..:.|:.:    |||   
Human   618 SDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPL----STL--- 675

  Fly  4552 SADRTTLSESPET-----PTTLPSDFTI---------------RPHSEQ-------------TTE 4583
                 |:..||||     ...|.|...|               |..|:|             ..:
Human   676 -----TVYYSPETIGRRVAVGLGSCLAILILAICGLKLQRRWKRTQSQQGLQENSSGQSFFVRNK 735

  Fly  4584 STRDVPTTRPFEASTPSPASLETTVPSVTSETTTNVPIGSTGGQVTGQTTAPPSEFRTTIRVEES 4648
            ..|..|.:.       .|.||....|.:....:                       .||:|..|.
Human   736 KVRRAPLSE-------GPHSLGCYNPMMEDGIS-----------------------YTTLRFPEM 770

  Fly  4649 TLPSRSTDRTTPSESPETPTILPSDSTTRTYS 4680
            .:|     ||..:||.|.....|....|.|||
Human   771 NIP-----RTGDAESSEMQRPPPDCDDTVTYS 797

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpyNP_001260032.1 EGF_3 137..166 CDD:289699
EGF_CA 212..247 CDD:238011
EGF_CA 255..>286 CDD:214542
EGF_CA 298..331 CDD:238011
EGF_CA 338..373 CDD:238011
EGF_CA 413..456 CDD:238011
EGF_CA 457..490 CDD:238011
EGF_CA 497..>529 CDD:214542
EGF_CA 580..>612 CDD:214542
EGF_3 676..702 CDD:289699
EGF_CA 1022..1056 CDD:214542
EGF_CA 2227..2260 CDD:238011
EGF_CA 2393..>2422 CDD:214542
DUF4758 4088..4282 CDD:292572 46/201 (23%)
DUF4696 4127..4678 CDD:292395 132/654 (20%)
DUF4758 4275..4448 CDD:292572 41/190 (22%)
DUF4758 4377..4574 CDD:292572 47/247 (19%)
DUF4758 4581..4754 CDD:292572 21/100 (21%)
DUF4758 4683..4847 CDD:292572
DUF4758 4785..4964 CDD:292572
DUF4696 4841..5385 CDD:292395
DUF4758 4887..5098 CDD:292572
DUF4758 5193..5371 CDD:292572
DUF4758 5294..5487 CDD:292572
DUF4758 5445..5650 CDD:292572
DUF4758 5700..5877 CDD:292572
DUF4696 5756..6396 CDD:292395
DUF4758 5802..5979 CDD:292572
DUF4758 5964..6171 CDD:292572
DUF4758 6181..6360 CDD:292572
DUF4696 6339..6999 CDD:292395
DUF4758 6662..6839 CDD:292572
DUF4758 6764..6941 CDD:292572
DUF4758 6866..7045 CDD:292572
DUF4758 6968..7179 CDD:292572
DUF4696 7024..7569 CDD:292395
DUF4758 7172..7383 CDD:292572
DUF4696 7330..7964 CDD:292395
DUF4758 7400..7587 CDD:292572
DUF4758 7538..7707 CDD:292572
DUF4758 7798..7979 CDD:292572
DUF4758 7946..8126 CDD:292572
YppG 18767..>18832 CDD:290883
Med25_SD1 18795..18955 CDD:288132
MISS 19026..19258 CDD:292450
ZP 22576..22811 CDD:214579
Zona_pellucida <22714..22810 CDD:278526
CD22NP_001762.2 Ig 24..122 CDD:299845
C2-set_2 143..228 CDD:285423 8/38 (21%)
I-set 242..327 CDD:254352 23/90 (26%)
IGc2 257..316 CDD:197706 15/61 (25%)
Ig_3 335..400 CDD:290638 15/71 (21%)
IG_like 343..415 CDD:214653 17/82 (21%)
IG_like 433..501 CDD:214653 14/67 (21%)
I-set 510..589 CDD:254352 16/79 (20%)
IGc2 521..578 CDD:197706 12/57 (21%)
IG_like 606..677 CDD:214653 13/82 (16%)
IGc2 608..666 CDD:197706 9/57 (16%)
ITIM motif 1 760..765 1/27 (4%)
ITIM motif 2 794..799 3/4 (75%)
ITIM motif 3 820..825
ITIM motif 4 840..845
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4475
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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