Protein Alignment dpy and NOLC1

DIOPT Version :9

• Sequence 1: NP_001260032.1
• Gene: dpy / 318824
• FlyBaseID: FBgn0053196
• Length: 22949
• Species: Drosophila melanogaster
• Sequence 2: XP_005270330.1
• Gene: NOLC1 / 9221
• HGNCID: 15608
• Length: 710
• Species: Homo sapiens
• Alignment Length: 804
• Identity: 156/804 - (19%)
• Similarity: 274/804 - (34%)
• Gaps: 184/804 - (22%)

  Fly  4804 SSASLETTVPS------------VTLETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPS 4856
            :.|.:...|||            ..|....|....:||....:...||..::.:......:.:|.
Human     2 ADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLNRSAKVPE 66

  Fly  4857 RSADRTTPSESPETPTTLPSDFITRPHSEKTTESTRDVPTTRPFEASTPSSASLETTVPSVTLET 4921
            |......|...........||      ||.::|...:|......:|:.|:.
Human    67 RKLQANGPVAKKAKKKASSSD------SEDSSEEEEEVQGPPAKKAAVPAK-------------- 111

  Fly  4922 TTNVPIGSTGGQVTEQTTSSPS------EVRTTIRVEESTLPSRSTDRTTPSESPETPTTLPSDF 4980
            ...:|.|....:.:|.::|..|      |.:....|::...|.....:..|.::..:.:...|..
Human   112 RVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSS 176

  Fly  4981 TTRPHSEQTTESTRDVPTTRPFEASTPSPASLETTVPSV-----TLETTTNVPIGSTGGQVTEQT 5040
            ...|...|..:.|   |.|  .:|.|.:|.......|.:     ...::::....|:.....|:.
Human   177 EDEPPKNQKPKIT---PVT--VKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKA 236

  Fly  5041 TSSPSEVRTTIRVEESTLPSRSADRTTPSESPETPTTLPSDFITRTYSDQTTESTRDVPTTRPFE 5105
            .::|.:|.|...|...|:|.:......|.::..|||       .::.|.:.:.|..:....:|.:
Human   237 AATPKKVWTITSVRAETVPKKQVVAKAPVKAATTPT-------RKSSSSEDSSSDEEEEQKKPMK 294

  Fly  5106 ASTPSPASLETTVPSVTSETTTNVPIGSTGGQVTGQTTAPPSEFRTTIRVEESTLPSRSTDRTTP 5170
             :.|.|.|              :||          ..:|||              |.:|.....|
Human   295 -NKPGPYS--------------SVP----------PPSAPP--------------PKKSLGTQPP 320

  Fly  5171 SESPETPTTLPSDFTTRPHSDQTTESTRDVPTTRPFEASTPSPASLETTVPSVTLETTTNVPIGS 5235
            .::.|....:.|...:...||.::|..:..||                  .:|..:.||..|
Human   321 KKAVEKQQPVESSEDSSDESDSSSEEEKKPPT------------------KAVVSKATTKPP--- 364

  Fly  5236 TGGQVTEQTTSSPSEVRTTIRVEESTLPSRSADRTTPSESPETPTLPSDFTTRPHSEQTTESTRD 5300
                        |::     :..||:..|..:|   .||..|.|:.|:.         ||:::.:
Human   365 ------------PAK-----KAAESSSDSSDSD---SSEDDEAPSKPAG---------TTKNSSN 400

  Fly  5301 VPATRPFEASTPSPASLETTVPSVTSEATTNVPIGSTGGQ--VTEQTTSSPSEVRTTIRVEESTL 5363
            .||     .:|.|||        |...|....|:|  |||  :|.:..||.||..::...||.|.
Human   401 KPA-----VTTKSPA--------VKPAAAPKQPVG--GGQKLLTRKADSSSSEEESSSSEEEKTK 450

  Fly  5364 PSRSTDRTSPSESPETPTTLPSDFTTRPHSDQTTECTRDVPTTRPFEASTPSSASLETTVPSVTL 5428
            ...:|  |.|..:.:...:||:  ...|...:.:....|..::...|..|..|| ::.....|..
Human   451 KMVAT--TKPKATAKAALSLPA--KQAPQGSRDSSSDSDSSSSEEEEEKTSKSA-VKKKPQKVAG 510

  Fly  5429 ETTTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSADRTTPSESPETPTLPS-DFTTRP 5492
            ....:.|..:..|:.....:||..:   :...||..|..:.:.|....::..|..|.: :.....
Human   511 GAAPSKPASAKKGKAESSNSSSSDD---SSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAK 572

  Fly  5493 HSEQTTESTRD----VPTTRPFEASTPSSASLETTVP---SVTLETTTNVPIGSTGGQVTEQTTS 5550
            :||:..|..:.    |..:...:....:.|:.|...|   .:.|:|....|....|    |:..|
Human   573 NSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKG----EKRAS 633

  Fly  5551 SPSEFRTTIRVEESTLPSRSADRT 5574
            ||  || .:|.||..:.||.||.:
Human   634 SP--FR-RVREEEIEVDSRVADNS 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572
		DUF4758	4581..4754	CDD:292572
		DUF4758	4683..4847	CDD:292572	10/54 (19%)
		DUF4758	4785..4964	CDD:292572	29/177 (16%)
		DUF4696	4841..5385	CDD:292395	104/556 (19%)
		DUF4758	4887..5098	CDD:292572	37/221 (17%)
		DUF4758	5193..5371	CDD:292572	41/179 (23%)
		DUF4758	5294..5487	CDD:292572	45/195 (23%)
		DUF4758	5445..5650	CDD:292572	32/138 (23%)
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
NOLC1	XP_005270330.1	SRP40_C	635..701	CDD:282829	10/23 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910