DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpy and Picalm

DIOPT Version :9

Sequence 1:	NP_001260032.1	Gene:	dpy / 318824	FlyBaseID:	FBgn0053196	Length:	22949	Species:	Drosophila melanogaster
Sequence 2:	XP_006229731.1	Gene:	Picalm / 89816	RGDID:	621054	Length:	686	Species:	Rattus norvegicus

Alignment Length:	561	Identity:	109/561 - (19%)
Similarity:	180/561 - (32%)	Gaps:	159/561 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  4462 TPTTLPSDFITRPHSEKTTESTRDVPTTRPFEASTPSSA--SLETTVPSVTLETTTNVPIGSTGG 4524
            |..|..|:|:  ..:|:......|:|..    :..|||.  :||..:.|:            .|.
  Rat   242 TRMTRISEFL--KVAEQVGIDRGDIPDL----SQAPSSLLDALEQHLASL------------EGK 288

  Fly  4525 QVTEQTTSSPSEVRTTIRVEESTLPSRSADRTTLSESPETPTTLPSDFTIRPHSEQTTESTRDVP 4589
            ::.:.|.:|.:   ||:....|:|.|.....|.:.|..:..........::...||..:.....|
  Rat   289 KIKDSTAASRA---TTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKP 350

  Fly  4590 TTRPFEASTPSPASLETTVPSVTSETTTNVPIGSTGGQVTGQTTAPPSEFRTTIRVEEST--LPS 4652
            .                     ||.||...|:.::.|   |..|||..:..:|.....||  ||:
  Rat   351 H---------------------TSLTTAASPVSTSAG---GIMTAPAIDIFSTPSSSNSTSKLPN 391

  Fly  4653 RSTDRTTPSESPETPTILPSDSTTRTYSDQTTESTRDVPTTRPFEASTPSPASLETTVPSVTLET 4717
            ...|...|:..|....:..:.....|:.|             ||.|:..   :::..:||:.
  Rat   392 DLLDLQQPTFHPSVHAMSAAPQVASTWGD-------------PFSATLD---AVDDAIPSLN--- 437

  Fly  4718 TTNVPIGSTGGQVTEQTTSSPSEVRTTIRVEESTLPSRSADRTTP--------SESPETPTTLPS 4774
                |.          .|.|..:|...|..:.||..:|     ||        |.||
  Rat   438 ----PF----------LTKSSGDVHLPISSDVSTFTTR-----TPTHEMFVGFSPSP-------- 475

  Fly  4775 DFITRPHSEKTTESTRDVPTTRPFEASTPSSASLETTVPSVTLETTTNVPIGSTG----GQVTEQ 4835
              :|:||                      .||.|.....||....:|||.:.|.|    |.:.:.
  Rat   476 --VTQPH----------------------PSAGLNVDFESVFGNKSTNVAVDSGGFDELGGLLKP 516

  Fly  4836 TTSSPSEVRTTIRVEESTLPSRSADRTTPSESPE----TPTTLPSDFITRPHSEKTTESTRDVPT 4896
            |.:|.::.....::..:.|.|...|.:..:....    ..||......::|..:|.|..:...|.
  Rat   517 TVASQNQSLPVAKLAPNKLVSDDLDSSLANLVGNLGIGNGTTKNDVSWSQPGEKKLTGGSNWQPK 581

  Fly  4897 TRP---FEASTPSSASLETTVPSVTLETTTNVPIGSTGGQVTEQTTSSPSEVRTTI--------- 4949
            ..|   :.|:|.:........|.|.....| .|.|..|..:..|..|.|...:.|:
  Rat   582 VAPTTAWSAATMNGMHFPQYAPPVMAYPAT-TPTGMIGYGIPPQMGSVPVMTQPTLIYSQPVMRP 645

  Fly  4950 ----------RVEESTLPSRSTDRTTPSESPETPTTLPSDF 4980
                      ::..::.|||.:......:.|....:| .||
  Rat   646 PNPFGPVPGAQLSAASSPSRHSPHRAAGKDPFAELSL-EDF 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpy	NP_001260032.1	EGF_3	137..166	CDD:289699
		EGF_CA	212..247	CDD:238011
		EGF_CA	255..>286	CDD:214542
		EGF_CA	298..331	CDD:238011
		EGF_CA	338..373	CDD:238011
		EGF_CA	413..456	CDD:238011
		EGF_CA	457..490	CDD:238011
		EGF_CA	497..>529	CDD:214542
		EGF_CA	580..>612	CDD:214542
		EGF_3	676..702	CDD:289699
		EGF_CA	1022..1056	CDD:214542
		EGF_CA	2227..2260	CDD:238011
		EGF_CA	2393..>2422	CDD:214542
		DUF4758	4088..4282	CDD:292572
		DUF4696	4127..4678	CDD:292395	44/219 (20%)
		DUF4758	4275..4448	CDD:292572
		DUF4758	4377..4574	CDD:292572	23/113 (20%)
		DUF4758	4581..4754	CDD:292572	33/174 (19%)
		DUF4758	4683..4847	CDD:292572	34/175 (19%)
		DUF4758	4785..4964	CDD:292572	38/208 (18%)
		DUF4696	4841..5385	CDD:292395	29/166 (17%)
		DUF4758	4887..5098	CDD:292572	22/116 (19%)
		DUF4758	5193..5371	CDD:292572
		DUF4758	5294..5487	CDD:292572
		DUF4758	5445..5650	CDD:292572
		DUF4758	5700..5877	CDD:292572
		DUF4696	5756..6396	CDD:292395
		DUF4758	5802..5979	CDD:292572
		DUF4758	5964..6171	CDD:292572
		DUF4758	6181..6360	CDD:292572
		DUF4696	6339..6999	CDD:292395
		DUF4758	6662..6839	CDD:292572
		DUF4758	6764..6941	CDD:292572
		DUF4758	6866..7045	CDD:292572
		DUF4758	6968..7179	CDD:292572
		DUF4696	7024..7569	CDD:292395
		DUF4758	7172..7383	CDD:292572
		DUF4696	7330..7964	CDD:292395
		DUF4758	7400..7587	CDD:292572
		DUF4758	7538..7707	CDD:292572
		DUF4758	7798..7979	CDD:292572
		DUF4758	7946..8126	CDD:292572
		YppG	18767..>18832	CDD:290883
		Med25_SD1	18795..18955	CDD:288132
		MISS	19026..19258	CDD:292450
		ZP	22576..22811	CDD:214579
		Zona_pellucida	<22714..22810	CDD:278526
Picalm	XP_006229731.1	ANTH	19..282	CDD:284961	12/45 (27%)
Picalm	XP_006229731.1	DASH_Spc19	<265..344	CDD:285487	19/97 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910